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Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells.
Phytomedicine. 2010 Apr; 17(5):363-8.P

Abstract

It is well known that the garlic-derived organosulfur compounds (OSCs) are effective to inhibit a variety of human cancers such as prostate, breast, colon, skin, lung, and bladder cancers. Herein, the pro-apoptotic effects of diallyl trisulfide (DATS), one of garlic-derived OSCs, on T24 bladder cancer cells were investigated. The results demonstrated that DATS suppressed proliferation of T24 bladder cancer cells in a dose- and time-dependent manner which was associated with induced G2/M Phase cell cycle arrest and apoptosis. Mechanistically, DATS inhibits phosphatidylinositol 3'-kinase/Akt activation that, in turn, results in modulation of Bcl-2 family proteins, leading to enhanced apoptosis of T24 cells. These findings suggest that DATS may be an effective way for treating human bladder and other types of cancers.

Authors+Show Affiliations

Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou 310003, Zhejiang Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19748259

Citation

Wang, Yun-Bin, et al. "Diallyl Trisulfide Induces Bcl-2 and Caspase-3-dependent Apoptosis Via Downregulation of Akt Phosphorylation in Human T24 Bladder Cancer Cells." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 17, no. 5, 2010, pp. 363-8.
Wang YB, Qin J, Zheng XY, et al. Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells. Phytomedicine. 2010;17(5):363-8.
Wang, Y. B., Qin, J., Zheng, X. Y., Bai, Y., Yang, K., & Xie, L. P. (2010). Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 17(5), 363-8. https://doi.org/10.1016/j.phymed.2009.07.019
Wang YB, et al. Diallyl Trisulfide Induces Bcl-2 and Caspase-3-dependent Apoptosis Via Downregulation of Akt Phosphorylation in Human T24 Bladder Cancer Cells. Phytomedicine. 2010;17(5):363-8. PubMed PMID: 19748259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diallyl trisulfide induces Bcl-2 and caspase-3-dependent apoptosis via downregulation of Akt phosphorylation in human T24 bladder cancer cells. AU - Wang,Yun-Bin, AU - Qin,Jie, AU - Zheng,Xiang-Yi, AU - Bai,Yu, AU - Yang,Kai, AU - Xie,Li-Ping, Y1 - 2009/09/11/ PY - 2009/03/12/received PY - 2009/06/17/revised PY - 2009/07/13/accepted PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2010/7/22/medline SP - 363 EP - 8 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 17 IS - 5 N2 - It is well known that the garlic-derived organosulfur compounds (OSCs) are effective to inhibit a variety of human cancers such as prostate, breast, colon, skin, lung, and bladder cancers. Herein, the pro-apoptotic effects of diallyl trisulfide (DATS), one of garlic-derived OSCs, on T24 bladder cancer cells were investigated. The results demonstrated that DATS suppressed proliferation of T24 bladder cancer cells in a dose- and time-dependent manner which was associated with induced G2/M Phase cell cycle arrest and apoptosis. Mechanistically, DATS inhibits phosphatidylinositol 3'-kinase/Akt activation that, in turn, results in modulation of Bcl-2 family proteins, leading to enhanced apoptosis of T24 cells. These findings suggest that DATS may be an effective way for treating human bladder and other types of cancers. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/19748259/Diallyl_trisulfide_induces_Bcl_2_and_caspase_3_dependent_apoptosis_via_downregulation_of_Akt_phosphorylation_in_human_T24_bladder_cancer_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(09)00190-1 DB - PRIME DP - Unbound Medicine ER -