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Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates.
Lancet. 2009 Sep 12; 374(9693):903-11.Lct

Abstract

BACKGROUND

Haemophilus influenzae type b (Hib) is a leading cause of childhood bacterial meningitis, pneumonia, and other serious infections. Hib disease can be almost completely eliminated through routine vaccination. We assessed the global burden of disease to help national policy makers and international donors set priorities.

METHODS

We did a comprehensive literature search of studies of Hib disease incidence, case-fatality ratios, age distribution, syndrome distribution, and effect of Hib vaccine. We used vaccine trial data to estimate the proportion of pneumonia cases and pneumonia deaths caused by Hib. We applied these proportions to WHO country-specific estimates of pneumonia cases and deaths to estimate Hib pneumonia burden. We used data from surveillance studies to develop estimates of incidence and mortality of Hib meningitis and serious non-pneumonia, non-meningitis disease. If available, high-quality data were used for national estimates of Hib meningitis and non-pneumonia, non-meningitis disease burden. Otherwise, estimates were based on data from other countries matched as closely as possible for geographic region and child mortality. Estimates were adjusted for HIV prevalence and access to care. Disease burden was estimated for the year 2000 in children younger than 5 years.

FINDINGS

We calculated that Hib caused about 8.13 million serious illnesses worldwide in 2000 (uncertainty range 7.33-13.2 million). We estimated that Hib caused 371,000 deaths (247,000-527,000) in children aged 1-59 months, of which 8100 (5600-10,000) were in HIV-positive and 363,000 (242,000-517,000) in HIV-negative children.

INTERPRETATION

Global burden of Hib disease is substantial and almost entirely vaccine preventable. Expanded use of Hib vaccine could reduce childhood pneumonia and meningitis, and decrease child mortality.

FUNDING

GAVI Alliance and the Vaccine Fund.

Authors+Show Affiliations

Hib Initiative, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. jwatt@jhsph.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19748399

Citation

Watt, James P., et al. "Burden of Disease Caused By Haemophilus Influenzae Type B in Children Younger Than 5 Years: Global Estimates." Lancet (London, England), vol. 374, no. 9693, 2009, pp. 903-11.
Watt JP, Wolfson LJ, O'Brien KL, et al. Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates. Lancet. 2009;374(9693):903-11.
Watt, J. P., Wolfson, L. J., O'Brien, K. L., Henkle, E., Deloria-Knoll, M., McCall, N., Lee, E., Levine, O. S., Hajjeh, R., Mulholland, K., & Cherian, T. (2009). Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates. Lancet (London, England), 374(9693), 903-11. https://doi.org/10.1016/S0140-6736(09)61203-4
Watt JP, et al. Burden of Disease Caused By Haemophilus Influenzae Type B in Children Younger Than 5 Years: Global Estimates. Lancet. 2009 Sep 12;374(9693):903-11. PubMed PMID: 19748399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates. AU - Watt,James P, AU - Wolfson,Lara J, AU - O'Brien,Katherine L, AU - Henkle,Emily, AU - Deloria-Knoll,Maria, AU - McCall,Natalie, AU - Lee,Ellen, AU - Levine,Orin S, AU - Hajjeh,Rana, AU - Mulholland,Kim, AU - Cherian,Thomas, AU - ,, PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2009/9/25/medline SP - 903 EP - 11 JF - Lancet (London, England) JO - Lancet VL - 374 IS - 9693 N2 - BACKGROUND: Haemophilus influenzae type b (Hib) is a leading cause of childhood bacterial meningitis, pneumonia, and other serious infections. Hib disease can be almost completely eliminated through routine vaccination. We assessed the global burden of disease to help national policy makers and international donors set priorities. METHODS: We did a comprehensive literature search of studies of Hib disease incidence, case-fatality ratios, age distribution, syndrome distribution, and effect of Hib vaccine. We used vaccine trial data to estimate the proportion of pneumonia cases and pneumonia deaths caused by Hib. We applied these proportions to WHO country-specific estimates of pneumonia cases and deaths to estimate Hib pneumonia burden. We used data from surveillance studies to develop estimates of incidence and mortality of Hib meningitis and serious non-pneumonia, non-meningitis disease. If available, high-quality data were used for national estimates of Hib meningitis and non-pneumonia, non-meningitis disease burden. Otherwise, estimates were based on data from other countries matched as closely as possible for geographic region and child mortality. Estimates were adjusted for HIV prevalence and access to care. Disease burden was estimated for the year 2000 in children younger than 5 years. FINDINGS: We calculated that Hib caused about 8.13 million serious illnesses worldwide in 2000 (uncertainty range 7.33-13.2 million). We estimated that Hib caused 371,000 deaths (247,000-527,000) in children aged 1-59 months, of which 8100 (5600-10,000) were in HIV-positive and 363,000 (242,000-517,000) in HIV-negative children. INTERPRETATION: Global burden of Hib disease is substantial and almost entirely vaccine preventable. Expanded use of Hib vaccine could reduce childhood pneumonia and meningitis, and decrease child mortality. FUNDING: GAVI Alliance and the Vaccine Fund. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/19748399/Burden_of_disease_caused_by_Haemophilus_influenzae_type_b_in_children_younger_than_5_years:_global_estimates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(09)61203-4 DB - PRIME DP - Unbound Medicine ER -