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Phenolic composition and antioxidant activities of two Phlomis species: A correlation study.
C R Biol. 2009 Sep; 332(9):816-26.CR

Abstract

Two traditional Chinese medicines (Phlomis umbrosa Turcz. and Phlomis megalantha Diels), as well as five pure phenolic compounds (protocatechic, chlorogenic, benzoic, rosmarinic acid, and rutin) have been studied for antioxidant activities in acetone and methanol extracts from leaves. An HPLC method was developed to quantify the amounts of 14 phenolic compounds in the leaf extracts. The antioxidant capacities of the studied species are high. Almost all samples were capable of directly scavenging DPPH and superoxide free radicals, inhibiting linoleic acid oxidation, acting as reducing agents, and reducing plasmid DNA damage induced by hydroxyl radicals. Among different extracts, the acetone extract of P. megalantha exhibited the highest antioxidant activity. The major phenolic compounds identified were protocatechic, chlorogenic, caffeic, rosmarinic acid, and (-)-epicatechin. Antioxidant activities of pure compounds and correlation analysis indicated that protocatechic and rosmarinic acids were the major contributors to the observed antioxidant activities of the investigated Phlomis extracts.

Authors+Show Affiliations

Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19748456

Citation

Zhang, Yuan, and Zhe-zhi Wang. "Phenolic Composition and Antioxidant Activities of Two Phlomis Species: a Correlation Study." Comptes Rendus Biologies, vol. 332, no. 9, 2009, pp. 816-26.
Zhang Y, Wang ZZ. Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. C R Biol. 2009;332(9):816-26.
Zhang, Y., & Wang, Z. Z. (2009). Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. Comptes Rendus Biologies, 332(9), 816-26. https://doi.org/10.1016/j.crvi.2009.05.006
Zhang Y, Wang ZZ. Phenolic Composition and Antioxidant Activities of Two Phlomis Species: a Correlation Study. C R Biol. 2009;332(9):816-26. PubMed PMID: 19748456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. AU - Zhang,Yuan, AU - Wang,Zhe-zhi, Y1 - 2009/08/05/ PY - 2009/03/17/received PY - 2009/05/08/revised PY - 2009/05/08/accepted PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2009/12/16/medline SP - 816 EP - 26 JF - Comptes rendus biologies JO - C R Biol VL - 332 IS - 9 N2 - Two traditional Chinese medicines (Phlomis umbrosa Turcz. and Phlomis megalantha Diels), as well as five pure phenolic compounds (protocatechic, chlorogenic, benzoic, rosmarinic acid, and rutin) have been studied for antioxidant activities in acetone and methanol extracts from leaves. An HPLC method was developed to quantify the amounts of 14 phenolic compounds in the leaf extracts. The antioxidant capacities of the studied species are high. Almost all samples were capable of directly scavenging DPPH and superoxide free radicals, inhibiting linoleic acid oxidation, acting as reducing agents, and reducing plasmid DNA damage induced by hydroxyl radicals. Among different extracts, the acetone extract of P. megalantha exhibited the highest antioxidant activity. The major phenolic compounds identified were protocatechic, chlorogenic, caffeic, rosmarinic acid, and (-)-epicatechin. Antioxidant activities of pure compounds and correlation analysis indicated that protocatechic and rosmarinic acids were the major contributors to the observed antioxidant activities of the investigated Phlomis extracts. SN - 1768-3238 UR - https://www.unboundmedicine.com/medline/citation/19748456/Phenolic_composition_and_antioxidant_activities_of_two_Phlomis_species:_A_correlation_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1631-0691(09)00167-X DB - PRIME DP - Unbound Medicine ER -