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Effect of over-the-counter fish-oil administration on plasma Lp(a) levels in an end-stage renal disease population.
J Ren Nutr. 2009 Nov; 19(6):443-9.JR

Abstract

OBJECTIVE

This study sought to examine the effect of n-3 supplementation on lipoprotein(a) (Lp(a)) levels in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis.

DESIGN

The present study was conducted using a double-blind, permuted-randomized, controlled experimental protocol.

SETTING

This study took place at the Central Texas Nephrology Associates Dialysis Clinic (Waco, TX).

PATIENTS

Patients with ESRD and associated with the Central Texas Nephrology Associates who were undergoing chronic hemodialysis participated in this study.

INTERVENTION

Patients with ESRD were followed prospectively while receiving supplements of fish oil (treatment, eicosapentaenoic acid, 0.96g/day, and docosahexaenoic acid, 0.6g/day) or corn oil (control subjects) for 6 months. After a 12-hour fast, participants donated 12mL of blood for analysis of Lp(a) at baseline and at 6 months.

MAIN OUTCOME MEASURE

The comparison of Lp(a) concentration by group at 6 months was the primary outcome measure of the study.

RESULTS

Our study suggests that fish-oil supplementation did not decrease levels of Lp(a) (P=.66), compared with control subjects.

CONCLUSION

We failed to show a significant effect of 6 months of over-the-counter fish-oil supplementation on Lp(a) status in an ESRD population, although results from this study support findings from other studies suggesting that African Americans have higher Lp(a) concentrations than persons of Caucasian decent.

Authors+Show Affiliations

Center for Exercise, Nutrition, and Preventive Health Research, Department of Health, Human Performance, and Recreation, School of Education, Baylor University, Waco, Texas 76798-7313, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19748798

Citation

Beavers, Kristen M., et al. "Effect of Over-the-counter Fish-oil Administration On Plasma Lp(a) Levels in an End-stage Renal Disease Population." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 19, no. 6, 2009, pp. 443-9.
Beavers KM, Beavers DP, Bowden RG, et al. Effect of over-the-counter fish-oil administration on plasma Lp(a) levels in an end-stage renal disease population. J Ren Nutr. 2009;19(6):443-9.
Beavers, K. M., Beavers, D. P., Bowden, R. G., Wilson, R. L., & Gentile, M. (2009). Effect of over-the-counter fish-oil administration on plasma Lp(a) levels in an end-stage renal disease population. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 19(6), 443-9. https://doi.org/10.1053/j.jrn.2009.06.005
Beavers KM, et al. Effect of Over-the-counter Fish-oil Administration On Plasma Lp(a) Levels in an End-stage Renal Disease Population. J Ren Nutr. 2009;19(6):443-9. PubMed PMID: 19748798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of over-the-counter fish-oil administration on plasma Lp(a) levels in an end-stage renal disease population. AU - Beavers,Kristen M, AU - Beavers,Daniel P, AU - Bowden,Rodney G, AU - Wilson,Ronald L, AU - Gentile,Mindy, Y1 - 2009/09/12/ PY - 2009/03/30/received PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2010/1/21/medline SP - 443 EP - 9 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 19 IS - 6 N2 - OBJECTIVE: This study sought to examine the effect of n-3 supplementation on lipoprotein(a) (Lp(a)) levels in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis. DESIGN: The present study was conducted using a double-blind, permuted-randomized, controlled experimental protocol. SETTING: This study took place at the Central Texas Nephrology Associates Dialysis Clinic (Waco, TX). PATIENTS: Patients with ESRD and associated with the Central Texas Nephrology Associates who were undergoing chronic hemodialysis participated in this study. INTERVENTION: Patients with ESRD were followed prospectively while receiving supplements of fish oil (treatment, eicosapentaenoic acid, 0.96g/day, and docosahexaenoic acid, 0.6g/day) or corn oil (control subjects) for 6 months. After a 12-hour fast, participants donated 12mL of blood for analysis of Lp(a) at baseline and at 6 months. MAIN OUTCOME MEASURE: The comparison of Lp(a) concentration by group at 6 months was the primary outcome measure of the study. RESULTS: Our study suggests that fish-oil supplementation did not decrease levels of Lp(a) (P=.66), compared with control subjects. CONCLUSION: We failed to show a significant effect of 6 months of over-the-counter fish-oil supplementation on Lp(a) status in an ESRD population, although results from this study support findings from other studies suggesting that African Americans have higher Lp(a) concentrations than persons of Caucasian decent. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/19748798/Effect_of_over_the_counter_fish_oil_administration_on_plasma_Lp_a__levels_in_an_end_stage_renal_disease_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(09)00156-3 DB - PRIME DP - Unbound Medicine ER -