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Uncommon manifestations of neuroborreliosis in children.
Eur J Paediatr Neurol. 2010 May; 14(3):274-7.EJ

Abstract

Lyme borreliosis is a tick-borne spirochetal infection which affects the skin, joints, heart and nervous system. Children with a neuroborreliosis usually present with a facial nerve palsy or aseptic meningitis, but the spectrum also includes other rare manifestations. We report four unusual cases of childhood neuroborreliosis and show that seizures with regional leptomeningeal enhancement, acute transverse myelitis, meningoradiculitis with pain and paraesthesia and cranial nerve palsies other than facial nerve palsy can be the leading symptoms of children with neuroborreliosis. All children had serological evidence of an acute infection with Borrelia burgdorferi, a pleocytosis in the cerebrospinal fluid and a complete response to antibiotic treatment. An intrathecal synthesis of IgG antibodies was detected in three children. Thus, diagnostic work up in children with unusual neurological symptoms should include cerebrospinal fluid studies with determination of the white blood cell count and calculation of the antibody index against B. burgdorferi.

Authors+Show Affiliations

Department of Pediatrics, Division of Pediatric Neurology and Inherited Metabolic Disorders, Medical University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. matthias.baumann@uki.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19748808

Citation

Baumann, Matthias, et al. "Uncommon Manifestations of Neuroborreliosis in Children." European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society, vol. 14, no. 3, 2010, pp. 274-7.
Baumann M, Birnbacher R, Koch J, et al. Uncommon manifestations of neuroborreliosis in children. Eur J Paediatr Neurol. 2010;14(3):274-7.
Baumann, M., Birnbacher, R., Koch, J., Strobl, R., & Rostásy, K. (2010). Uncommon manifestations of neuroborreliosis in children. European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society, 14(3), 274-7. https://doi.org/10.1016/j.ejpn.2009.08.003
Baumann M, et al. Uncommon Manifestations of Neuroborreliosis in Children. Eur J Paediatr Neurol. 2010;14(3):274-7. PubMed PMID: 19748808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uncommon manifestations of neuroborreliosis in children. AU - Baumann,Matthias, AU - Birnbacher,Robert, AU - Koch,Johannes, AU - Strobl,Robert, AU - Rostásy,Kevin, Y1 - 2009/09/12/ PY - 2008/12/23/received PY - 2009/07/10/revised PY - 2009/08/03/accepted PY - 2009/9/15/entrez PY - 2009/9/15/pubmed PY - 2010/7/14/medline SP - 274 EP - 7 JF - European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society JO - Eur. J. Paediatr. Neurol. VL - 14 IS - 3 N2 - Lyme borreliosis is a tick-borne spirochetal infection which affects the skin, joints, heart and nervous system. Children with a neuroborreliosis usually present with a facial nerve palsy or aseptic meningitis, but the spectrum also includes other rare manifestations. We report four unusual cases of childhood neuroborreliosis and show that seizures with regional leptomeningeal enhancement, acute transverse myelitis, meningoradiculitis with pain and paraesthesia and cranial nerve palsies other than facial nerve palsy can be the leading symptoms of children with neuroborreliosis. All children had serological evidence of an acute infection with Borrelia burgdorferi, a pleocytosis in the cerebrospinal fluid and a complete response to antibiotic treatment. An intrathecal synthesis of IgG antibodies was detected in three children. Thus, diagnostic work up in children with unusual neurological symptoms should include cerebrospinal fluid studies with determination of the white blood cell count and calculation of the antibody index against B. burgdorferi. SN - 1532-2130 UR - https://www.unboundmedicine.com/medline/citation/19748808/Uncommon_manifestations_of_neuroborreliosis_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-3798(09)00154-8 DB - PRIME DP - Unbound Medicine ER -