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Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits.
J Obstet Gynaecol Res. 2009 Aug; 35(4):630-9.JO

Abstract

AIM

To review the scientific publications concerning the clinical use and mechanism of action of the North American cranberry (Vaccinium macrocarpon) for women with recurrent urinary tract infections (UTI) and other health conditions.

METHODS

This is a retrospective study of published information concerning Vaccinium macrocarpon retrieved from a PubMed and individual searches.

RESULTS

Urinary tract infections are very common in women, cause discomfort, and may aggravate other genitourinary conditions. The available scientific information supports a clinical benefit of Vaccinium macrocarpon in the prevention of recurrent UTI in women. There is a non-significant reduction of UTI associated with Vaccinium macrocarpon treatment during pregnancy. A group of proanthocyanidins (PAC) with A-type linkages have been isolated from Vaccinium macrocarpon which inhibit P-fimbriae synthesis and induce a bacterial deformation, on both antibiotic-susceptible and antibiotic-resistant uropathogenic Escherichia coli. It is plausible that cranberry PAC prevent bacteria from adhering to the uroepithelium of the bladder, thereby blocking the ability of E. coli to infect the urinary mucosa.

CONCLUSION

Cranberry treatment is a safe, well-tolerated supplement that does not have significant drug interactions. Although investigations are in the early stages, experimental and preclinical studies suggest that cranberry components may have other potential benefits, including anti-infective, anticancer and antioxidant effects, which may be considered as positive for different age-related conditions. In addition, cranberry components may induce positive cardiovascular and metabolic changes, and may improve neuropsychological activity. These effects warrant further clinical research to better place the role of cranberry products for women.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine, Clínico Universitario de Zaragoza Hospital, Zaragoza, Spain. faustino.perez@unizar.esNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19751320

Citation

Pérez-López, Faustino R., et al. "Vaccinium Macrocarpon: an Interesting Option for Women With Recurrent Urinary Tract Infections and Other Health Benefits." The Journal of Obstetrics and Gynaecology Research, vol. 35, no. 4, 2009, pp. 630-9.
Pérez-López FR, Haya J, Chedraui P. Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits. J Obstet Gynaecol Res. 2009;35(4):630-9.
Pérez-López, F. R., Haya, J., & Chedraui, P. (2009). Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits. The Journal of Obstetrics and Gynaecology Research, 35(4), 630-9. https://doi.org/10.1111/j.1447-0756.2009.01026.x
Pérez-López FR, Haya J, Chedraui P. Vaccinium Macrocarpon: an Interesting Option for Women With Recurrent Urinary Tract Infections and Other Health Benefits. J Obstet Gynaecol Res. 2009;35(4):630-9. PubMed PMID: 19751320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccinium macrocarpon: an interesting option for women with recurrent urinary tract infections and other health benefits. AU - Pérez-López,Faustino R, AU - Haya,Javier, AU - Chedraui,Peter, PY - 2009/9/16/entrez PY - 2009/9/16/pubmed PY - 2009/11/17/medline SP - 630 EP - 9 JF - The journal of obstetrics and gynaecology research JO - J. Obstet. Gynaecol. Res. VL - 35 IS - 4 N2 - AIM: To review the scientific publications concerning the clinical use and mechanism of action of the North American cranberry (Vaccinium macrocarpon) for women with recurrent urinary tract infections (UTI) and other health conditions. METHODS: This is a retrospective study of published information concerning Vaccinium macrocarpon retrieved from a PubMed and individual searches. RESULTS: Urinary tract infections are very common in women, cause discomfort, and may aggravate other genitourinary conditions. The available scientific information supports a clinical benefit of Vaccinium macrocarpon in the prevention of recurrent UTI in women. There is a non-significant reduction of UTI associated with Vaccinium macrocarpon treatment during pregnancy. A group of proanthocyanidins (PAC) with A-type linkages have been isolated from Vaccinium macrocarpon which inhibit P-fimbriae synthesis and induce a bacterial deformation, on both antibiotic-susceptible and antibiotic-resistant uropathogenic Escherichia coli. It is plausible that cranberry PAC prevent bacteria from adhering to the uroepithelium of the bladder, thereby blocking the ability of E. coli to infect the urinary mucosa. CONCLUSION: Cranberry treatment is a safe, well-tolerated supplement that does not have significant drug interactions. Although investigations are in the early stages, experimental and preclinical studies suggest that cranberry components may have other potential benefits, including anti-infective, anticancer and antioxidant effects, which may be considered as positive for different age-related conditions. In addition, cranberry components may induce positive cardiovascular and metabolic changes, and may improve neuropsychological activity. These effects warrant further clinical research to better place the role of cranberry products for women. SN - 1341-8076 UR - https://www.unboundmedicine.com/medline/citation/19751320/Vaccinium_macrocarpon:_an_interesting_option_for_women_with_recurrent_urinary_tract_infections_and_other_health_benefits_ L2 - https://doi.org/10.1111/j.1447-0756.2009.01026.x DB - PRIME DP - Unbound Medicine ER -