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A re-evaluation of the mechanisms leading to dengue hemorrhagic fever.
Ann N Y Acad Sci. 2009 Sep; 1171 Suppl 1:E24-35.AN

Abstract

Viremia is one of the features of dengue virus infection among the flaviviruses. Dengue virus infection results in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), a life-threatening illness. Several mechanisms have been hypothesized based primarily on data collected from post-acute clinical phase to account for DHF/DSS. Lack of a suitable animal model for DHF/DSS has hindered progress in defining the etiology of DHF/DSS. Levels of circulating dengue virus have been well-correlated to severe dengue disease. However, the cell lineage(s) serving as a primary target for the source of viremia are largely unknown. Results from in vivo and in vitro pilot studies using molecular and more advanced technologies reveal that dengue virus appears to be associated with platelets and the megakaryocytic lineage. The observation may partially explain the dysfunction of platelets observed in dengue affected patients.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19751399

Citation

Noisakran, Sansanee, et al. "A Re-evaluation of the Mechanisms Leading to Dengue Hemorrhagic Fever." Annals of the New York Academy of Sciences, vol. 1171 Suppl 1, 2009, pp. E24-35.
Noisakran S, Chokephaibulkit K, Songprakhon P, et al. A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. Ann N Y Acad Sci. 2009;1171 Suppl 1:E24-35.
Noisakran, S., Chokephaibulkit, K., Songprakhon, P., Onlamoon, N., Hsiao, H. M., Villinger, F., Ansari, A., & Perng, G. C. (2009). A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. Annals of the New York Academy of Sciences, 1171 Suppl 1, E24-35. https://doi.org/10.1111/j.1749-6632.2009.05050.x
Noisakran S, et al. A Re-evaluation of the Mechanisms Leading to Dengue Hemorrhagic Fever. Ann N Y Acad Sci. 2009;1171 Suppl 1:E24-35. PubMed PMID: 19751399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A re-evaluation of the mechanisms leading to dengue hemorrhagic fever. AU - Noisakran,Sansanee, AU - Chokephaibulkit,Kulkanya, AU - Songprakhon,Pucharee, AU - Onlamoon,Nattawat, AU - Hsiao,Hui-Mien, AU - Villinger,Francois, AU - Ansari,Aftab, AU - Perng,Guey Chuen, PY - 2009/9/16/entrez PY - 2009/9/16/pubmed PY - 2009/10/24/medline SP - E24 EP - 35 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1171 Suppl 1 N2 - Viremia is one of the features of dengue virus infection among the flaviviruses. Dengue virus infection results in a spectrum of clinical symptoms, ranging from undifferentiated flu-like illness, mild dengue fever, to dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), a life-threatening illness. Several mechanisms have been hypothesized based primarily on data collected from post-acute clinical phase to account for DHF/DSS. Lack of a suitable animal model for DHF/DSS has hindered progress in defining the etiology of DHF/DSS. Levels of circulating dengue virus have been well-correlated to severe dengue disease. However, the cell lineage(s) serving as a primary target for the source of viremia are largely unknown. Results from in vivo and in vitro pilot studies using molecular and more advanced technologies reveal that dengue virus appears to be associated with platelets and the megakaryocytic lineage. The observation may partially explain the dysfunction of platelets observed in dengue affected patients. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/19751399/A_re_evaluation_of_the_mechanisms_leading_to_dengue_hemorrhagic_fever_ L2 - https://doi.org/10.1111/j.1749-6632.2009.05050.x DB - PRIME DP - Unbound Medicine ER -