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Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus.
Ann N Y Acad Sci 2009; 1173 Suppl 1:E64-7AN

Abstract

The aims of this study were to evaluate the prevalence of osteopenia and the relationships between osteocalcin (OC), bone alkaline phosphatase (bALP), and bone mineral density (BMD) in patients with insulin-dependent diabetes mellitus (IDDM). A group of 18 patients (median age 47, range 36-51) with uncomplicated IDDM (Group A) were matched by sex, age, and body mass index with 21 healthy control volunteers (Group B). All subjects underwent osteodensitometry with measurement of BMD at the lumbar spine and femoral neck. Osteopenia was present in 11 (61.1%) and 2 (9.5%) of Group A and B patients (P= 0.01), respectively. Both OC (28.4 +/- 16.4 versus 41.2 +/- 14.6 ng/mL; P= 0.005) and bALP (51.3 +/- 11.8 versus 61.7 +/- 10.6 U/L; P= 0.006) serum levels were significantly lower in patients with IDDM. BMD did not correlate with either OC or bALP. In conclusion, osteopenia is common among patients with IDDM, but the relationship between bone formation markers and BMD is still unclear.

Authors+Show Affiliations

Department of Surgical & Gastroenterological Sciences, University of Padua, Italy. flumachi@unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19751417

Citation

Lumachi, Franco, et al. "Bone Mineral Density, Osteocalcin, and Bone-specific Alkaline Phosphatase in Patients With Insulin-dependent Diabetes Mellitus." Annals of the New York Academy of Sciences, vol. 1173 Suppl 1, 2009, pp. E64-7.
Lumachi F, Camozzi V, Tombolan V, et al. Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus. Ann N Y Acad Sci. 2009;1173 Suppl 1:E64-7.
Lumachi, F., Camozzi, V., Tombolan, V., & Luisetto, G. (2009). Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus. Annals of the New York Academy of Sciences, 1173 Suppl 1, pp. E64-7. doi:10.1111/j.1749-6632.2009.04955.x.
Lumachi F, et al. Bone Mineral Density, Osteocalcin, and Bone-specific Alkaline Phosphatase in Patients With Insulin-dependent Diabetes Mellitus. Ann N Y Acad Sci. 2009;1173 Suppl 1:E64-7. PubMed PMID: 19751417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus. AU - Lumachi,Franco, AU - Camozzi,Valentina, AU - Tombolan,Valeria, AU - Luisetto,Giovanni, PY - 2009/9/16/entrez PY - 2009/9/16/pubmed PY - 2009/10/24/medline SP - E64 EP - 7 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 1173 Suppl 1 N2 - The aims of this study were to evaluate the prevalence of osteopenia and the relationships between osteocalcin (OC), bone alkaline phosphatase (bALP), and bone mineral density (BMD) in patients with insulin-dependent diabetes mellitus (IDDM). A group of 18 patients (median age 47, range 36-51) with uncomplicated IDDM (Group A) were matched by sex, age, and body mass index with 21 healthy control volunteers (Group B). All subjects underwent osteodensitometry with measurement of BMD at the lumbar spine and femoral neck. Osteopenia was present in 11 (61.1%) and 2 (9.5%) of Group A and B patients (P= 0.01), respectively. Both OC (28.4 +/- 16.4 versus 41.2 +/- 14.6 ng/mL; P= 0.005) and bALP (51.3 +/- 11.8 versus 61.7 +/- 10.6 U/L; P= 0.006) serum levels were significantly lower in patients with IDDM. BMD did not correlate with either OC or bALP. In conclusion, osteopenia is common among patients with IDDM, but the relationship between bone formation markers and BMD is still unclear. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/19751417/Bone_mineral_density_osteocalcin_and_bone_specific_alkaline_phosphatase_in_patients_with_insulin_dependent_diabetes_mellitus_ L2 - https://doi.org/10.1111/j.1749-6632.2009.04955.x DB - PRIME DP - Unbound Medicine ER -