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Clan CD of cysteine peptidases as an example of evolutionary divergences in related protein families across plant clades.
Gene. 2010 Jan 01; 449(1-2):59-69.GENE

Abstract

Comparative genomic analyses are powerful tools that can be used to analyze the presence, conservation, and evolution of protein families and to elucidate issues concerning their function. To deal with these questions, we have chosen the clan CD of cysteine peptidases, which is formed by different protein families that play key roles in plants. An evolutionary comparative analysis of clan CD cysteine peptidases in representative species of different taxonomic groups that appeared during the evolution of the Viridiplantae was performed. The results obtained indicates: i) C13 GPI:protein transamidases, C14 metacaspases I, and C50 separases are present in all taxonomic groups; ii) C13 legumains and C14 metacaspases II are absent in some basal algae groups; iii) C11 clostripains have only been found in the two Chlorophyceae species; iv) C25 gingipains and C80 RTX toxins have not been found in plants. Moreover, gene duplication events could have been associated in some families to the increasing complexities acquired in land plants. These findings have demonstrated that comparative genomics is useful to provide valuable insights on the differential evolution of the related peptidase families belonging to clan CD in plant clades. The low number of protein members suggests a restricted physiological role for these peptidase families, mainly in algae species.

Authors+Show Affiliations

Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus Montegancedo, 28223-Pozuelo de Alarcón (Madrid), Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19751811

Citation

Cambra, Ines, et al. "Clan CD of Cysteine Peptidases as an Example of Evolutionary Divergences in Related Protein Families Across Plant Clades." Gene, vol. 449, no. 1-2, 2010, pp. 59-69.
Cambra I, Garcia FJ, Martinez M. Clan CD of cysteine peptidases as an example of evolutionary divergences in related protein families across plant clades. Gene. 2010;449(1-2):59-69.
Cambra, I., Garcia, F. J., & Martinez, M. (2010). Clan CD of cysteine peptidases as an example of evolutionary divergences in related protein families across plant clades. Gene, 449(1-2), 59-69. https://doi.org/10.1016/j.gene.2009.09.003
Cambra I, Garcia FJ, Martinez M. Clan CD of Cysteine Peptidases as an Example of Evolutionary Divergences in Related Protein Families Across Plant Clades. Gene. 2010 Jan 1;449(1-2):59-69. PubMed PMID: 19751811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clan CD of cysteine peptidases as an example of evolutionary divergences in related protein families across plant clades. AU - Cambra,Ines, AU - Garcia,Francisco J, AU - Martinez,Manuel, Y1 - 2009/09/12/ PY - 2009/05/14/received PY - 2009/08/28/revised PY - 2009/09/05/accepted PY - 2009/9/16/entrez PY - 2009/9/16/pubmed PY - 2009/12/16/medline SP - 59 EP - 69 JF - Gene JO - Gene VL - 449 IS - 1-2 N2 - Comparative genomic analyses are powerful tools that can be used to analyze the presence, conservation, and evolution of protein families and to elucidate issues concerning their function. To deal with these questions, we have chosen the clan CD of cysteine peptidases, which is formed by different protein families that play key roles in plants. An evolutionary comparative analysis of clan CD cysteine peptidases in representative species of different taxonomic groups that appeared during the evolution of the Viridiplantae was performed. The results obtained indicates: i) C13 GPI:protein transamidases, C14 metacaspases I, and C50 separases are present in all taxonomic groups; ii) C13 legumains and C14 metacaspases II are absent in some basal algae groups; iii) C11 clostripains have only been found in the two Chlorophyceae species; iv) C25 gingipains and C80 RTX toxins have not been found in plants. Moreover, gene duplication events could have been associated in some families to the increasing complexities acquired in land plants. These findings have demonstrated that comparative genomics is useful to provide valuable insights on the differential evolution of the related peptidase families belonging to clan CD in plant clades. The low number of protein members suggests a restricted physiological role for these peptidase families, mainly in algae species. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/19751811/Clan_CD_of_cysteine_peptidases_as_an_example_of_evolutionary_divergences_in_related_protein_families_across_plant_clades_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(09)00480-6 DB - PRIME DP - Unbound Medicine ER -