Tags

Type your tag names separated by a space and hit enter

Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: Community-Acquired Pneumonia Organization International cohort study results.
Arch Intern Med. 2009 Sep 14; 169(16):1515-24.AI

Abstract

BACKGROUND

To define whether elderly patients hospitalized with community-acquired pneumonia (CAP) had better outcomes if they were treated with empirical antimicrobial therapy adherent to the 2007 Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) guidelines for CAP.

METHODS

This was a secondary analysis of the CAPO International Cohort Study database, which contained data from a total of 1725 patients aged 65 years or older who were hospitalized with CAP. Data from June 1, 2001, until January 1, 2007, were analyzed from 43 centers in 12 countries including North America (n = 2), South America (n = 4), Europe (n = 4), Africa (n = 1), and Southeast Asia (n = 1). Initial empirical therapy for CAP was evaluated for guideline compliance according to the 2007 IDSA/ATS guidelines for CAP. Time to clinical stability, length of stay (LOS), total in-hospital mortality, and CAP-related mortality for each group were calculated. Comparisons between groups were made using cumulative incidence curves and competing risks regression.

RESULTS

Among the 1649 patients with CAP, aged 65 years or older, 975 patients were given antimicrobial regimens adherent to the IDSA/ATS for CAP guidelines, while 660 patients were treated with nonadherent regimens (465 patients were "undertreated"; 195 were "overtreated"). Adherence to guidelines was associated with a statistically significant decreased time to achieve clinical stability compared with nonadherence: the proportion of patients who reached clinical stability by 7 days was 71% (95% confidence interval [CI], 68%-74%) and 57% (95% CI, 53%-61%) (P < .01), respectively. Guideline adherence was also associated with shorter LOS (median adherence LOS, 8 days; interquartile range [IQR], 5-15 days; median nonadherence LOS, 10 days; IQR, 6-24 days) (P < .01) and decreased overall in-hospital mortality (8%; 95% CI, 7%-10% vs 17%; 95% CI, 14%-20%) (P < .01).

CONCLUSION

Implementation of national guidelines at the local hospital level will improve not only mortality and LOS of elderly patients hospitalized with CAP but also time to clinical stability.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Louisville, 627 Preston St, Ste 100, Louisville, KY 40202, USA. f.arnold@louisville.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

19752410

Citation

Arnold, Forest W., et al. "Improving Outcomes in Elderly Patients With Community-acquired Pneumonia By Adhering to National Guidelines: Community-Acquired Pneumonia Organization International Cohort Study Results." Archives of Internal Medicine, vol. 169, no. 16, 2009, pp. 1515-24.
Arnold FW, LaJoie AS, Brock GN, et al. Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: Community-Acquired Pneumonia Organization International cohort study results. Arch Intern Med. 2009;169(16):1515-24.
Arnold, F. W., LaJoie, A. S., Brock, G. N., Peyrani, P., Rello, J., Menéndez, R., Lopardo, G., Torres, A., Rossi, P., & Ramirez, J. A. (2009). Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: Community-Acquired Pneumonia Organization International cohort study results. Archives of Internal Medicine, 169(16), 1515-24. https://doi.org/10.1001/archinternmed.2009.265
Arnold FW, et al. Improving Outcomes in Elderly Patients With Community-acquired Pneumonia By Adhering to National Guidelines: Community-Acquired Pneumonia Organization International Cohort Study Results. Arch Intern Med. 2009 Sep 14;169(16):1515-24. PubMed PMID: 19752410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improving outcomes in elderly patients with community-acquired pneumonia by adhering to national guidelines: Community-Acquired Pneumonia Organization International cohort study results. AU - Arnold,Forest W, AU - LaJoie,A Scott, AU - Brock,Guy N, AU - Peyrani,Paula, AU - Rello,Jordi, AU - Menéndez,Rosario, AU - Lopardo,Gustavo, AU - Torres,Antoni, AU - Rossi,Paolo, AU - Ramirez,Julio A, AU - ,, PY - 2009/9/16/entrez PY - 2009/9/16/pubmed PY - 2009/10/3/medline SP - 1515 EP - 24 JF - Archives of internal medicine JO - Arch Intern Med VL - 169 IS - 16 N2 - BACKGROUND: To define whether elderly patients hospitalized with community-acquired pneumonia (CAP) had better outcomes if they were treated with empirical antimicrobial therapy adherent to the 2007 Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) guidelines for CAP. METHODS: This was a secondary analysis of the CAPO International Cohort Study database, which contained data from a total of 1725 patients aged 65 years or older who were hospitalized with CAP. Data from June 1, 2001, until January 1, 2007, were analyzed from 43 centers in 12 countries including North America (n = 2), South America (n = 4), Europe (n = 4), Africa (n = 1), and Southeast Asia (n = 1). Initial empirical therapy for CAP was evaluated for guideline compliance according to the 2007 IDSA/ATS guidelines for CAP. Time to clinical stability, length of stay (LOS), total in-hospital mortality, and CAP-related mortality for each group were calculated. Comparisons between groups were made using cumulative incidence curves and competing risks regression. RESULTS: Among the 1649 patients with CAP, aged 65 years or older, 975 patients were given antimicrobial regimens adherent to the IDSA/ATS for CAP guidelines, while 660 patients were treated with nonadherent regimens (465 patients were "undertreated"; 195 were "overtreated"). Adherence to guidelines was associated with a statistically significant decreased time to achieve clinical stability compared with nonadherence: the proportion of patients who reached clinical stability by 7 days was 71% (95% confidence interval [CI], 68%-74%) and 57% (95% CI, 53%-61%) (P < .01), respectively. Guideline adherence was also associated with shorter LOS (median adherence LOS, 8 days; interquartile range [IQR], 5-15 days; median nonadherence LOS, 10 days; IQR, 6-24 days) (P < .01) and decreased overall in-hospital mortality (8%; 95% CI, 7%-10% vs 17%; 95% CI, 14%-20%) (P < .01). CONCLUSION: Implementation of national guidelines at the local hospital level will improve not only mortality and LOS of elderly patients hospitalized with CAP but also time to clinical stability. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/19752410/Improving_outcomes_in_elderly_patients_with_community_acquired_pneumonia_by_adhering_to_national_guidelines:_Community_Acquired_Pneumonia_Organization_International_cohort_study_results_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2009.265 DB - PRIME DP - Unbound Medicine ER -