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Leisure activities and the risk of dementia in the elderly: results from the Three-City Study.

Abstract

OBJECTIVE

There is accumulating evidence that involvement in leisure activities may be related to risk of dementia; however, there is no consensus concerning the underlying mechanism of this association. Hypothesizing that leisure activities may contribute to cognitive reserve (CR), we examined the association between leisure activities and risk of incident dementia and its subtypes within a general population sample, categorizing leisure activity as stimulating, passive, physical, and social. The possibility that these associations may be driven by other proxies of CR was also examined.

METHODS

Analyses were carried out on 5,698 dementia-free participants aged 65 and over included in the Three-City cohort study in Dijon and Montpellier (France) in 1999-2001. Hazard ratios (HR) were calculated for incident dementia and its subtypes (mixed/vascular dementia and Alzheimer disease) in relation to category of leisure activity.

RESULTS

Stimulating leisure activities were found to be significantly associated with a reduced risk of dementia (n = 161, HR = 0.49, 95% confidence interval [CI]: 0.31; 0.79) and Alzheimer disease (n = 105, HR = 0.39, 95% CI: 0.21; 0.71) over the 4-year follow-up 1) independently of other proxies of CR, 2) after adjusting for vascular risk factors, depressive symptoms, and physical functioning, and 3) independently of other leisure activities. Furthermore, no significant association was found with other leisure activities and dementia after controlling for the potential confounders.

CONCLUSION

Our findings support the hypothesis that cognitively stimulating leisure activities may delay the onset of dementia in community-dwelling elders.

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  • Authors+Show Affiliations

    ,

    INSERM U888, Hôpital La Colombière, 39 Avenue Charles Flahault, BP 34493, 34093 Montpellier, Cedex 5, France. tasnime.akbaraly@inserm.fr

    , , , , , , ,

    Source

    Neurology 73:11 2009 Sep 15 pg 854-61

    MeSH

    Aged
    Aged, 80 and over
    Dementia
    Female
    France
    Humans
    Leisure Activities
    Neuropsychological Tests
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19752452

    Citation

    Akbaraly, T N., et al. "Leisure Activities and the Risk of Dementia in the Elderly: Results From the Three-City Study." Neurology, vol. 73, no. 11, 2009, pp. 854-61.
    Akbaraly TN, Portet F, Fustinoni S, et al. Leisure activities and the risk of dementia in the elderly: results from the Three-City Study. Neurology. 2009;73(11):854-61.
    Akbaraly, T. N., Portet, F., Fustinoni, S., Dartigues, J. F., Artero, S., Rouaud, O., ... Berr, C. (2009). Leisure activities and the risk of dementia in the elderly: results from the Three-City Study. Neurology, 73(11), pp. 854-61. doi:10.1212/WNL.0b013e3181b7849b.
    Akbaraly TN, et al. Leisure Activities and the Risk of Dementia in the Elderly: Results From the Three-City Study. Neurology. 2009 Sep 15;73(11):854-61. PubMed PMID: 19752452.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Leisure activities and the risk of dementia in the elderly: results from the Three-City Study. AU - Akbaraly,T N, AU - Portet,F, AU - Fustinoni,S, AU - Dartigues,J-F, AU - Artero,S, AU - Rouaud,O, AU - Touchon,J, AU - Ritchie,K, AU - Berr,C, PY - 2009/9/16/entrez PY - 2009/9/16/pubmed PY - 2009/9/29/medline SP - 854 EP - 61 JF - Neurology JO - Neurology VL - 73 IS - 11 N2 - OBJECTIVE: There is accumulating evidence that involvement in leisure activities may be related to risk of dementia; however, there is no consensus concerning the underlying mechanism of this association. Hypothesizing that leisure activities may contribute to cognitive reserve (CR), we examined the association between leisure activities and risk of incident dementia and its subtypes within a general population sample, categorizing leisure activity as stimulating, passive, physical, and social. The possibility that these associations may be driven by other proxies of CR was also examined. METHODS: Analyses were carried out on 5,698 dementia-free participants aged 65 and over included in the Three-City cohort study in Dijon and Montpellier (France) in 1999-2001. Hazard ratios (HR) were calculated for incident dementia and its subtypes (mixed/vascular dementia and Alzheimer disease) in relation to category of leisure activity. RESULTS: Stimulating leisure activities were found to be significantly associated with a reduced risk of dementia (n = 161, HR = 0.49, 95% confidence interval [CI]: 0.31; 0.79) and Alzheimer disease (n = 105, HR = 0.39, 95% CI: 0.21; 0.71) over the 4-year follow-up 1) independently of other proxies of CR, 2) after adjusting for vascular risk factors, depressive symptoms, and physical functioning, and 3) independently of other leisure activities. Furthermore, no significant association was found with other leisure activities and dementia after controlling for the potential confounders. CONCLUSION: Our findings support the hypothesis that cognitively stimulating leisure activities may delay the onset of dementia in community-dwelling elders. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/19752452/Leisure_activities_and_the_risk_of_dementia_in_the_elderly:_results_from_the_Three_City_Study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=19752452 DB - PRIME DP - Unbound Medicine ER -