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Correlation between upgrading of prostate biopsy and biochemical failure and unfavorable pathology after radical prostatectomy.
Urol Int. 2009; 83(2):146-50.UI

Abstract

OBJECTIVE

To evaluate whether upgrading of the biopsy after radical prostatectomy (RP) affects disease outcome in terms of unfavorable pathology and biochemical failure.

PATIENTS AND METHODS

We retrospectively evaluated the records of 174 patients who underwent RP. Prostate biopsy and RP specimen Gleason scores (GSs) and correlative clinical data were recorded, and a multivariate analysis was applied.

RESULTS

Overall (138 patients), the disease of 69 men (50.0%) was upgraded, in 19 (13.8%) it was downgraded, and in 50 (36.2%) it had an identical biopsy and pathological GS. Accuracy rates were significantly higher for GS 8-10 compared to low GSs, with a concordance of 50.0 and 12.2%, respectively (p < 0.01). Multivariate analysis revealed the single independent prognostic factor for a non-organ-confined disease as a RP GS 8-10 (p = 0.035). The factors associated with a positive surgical margin were a biopsy GS 8-10 (p < 0.001) and the presence of biopsy score upgrading (p = 0.02). Biopsy GS >or=8 (p < 0.001) and presence of biopsy score upgrading (p = 0.009) were the two independent predictors of relapse after RP.

CONCLUSION

This study demonstrated that biopsy upgrading was present in almost half of the patients who underwent RP and it was significantly related to positive surgical margins and biochemical relapse after RP.

Authors+Show Affiliations

Department of Urology, Numune Education and Research Hospital, Ankara, Turkey. cuneytozden@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19752607

Citation

Ozden, Cuneyt, et al. "Correlation Between Upgrading of Prostate Biopsy and Biochemical Failure and Unfavorable Pathology After Radical Prostatectomy." Urologia Internationalis, vol. 83, no. 2, 2009, pp. 146-50.
Ozden C, Oztekin CV, Ugurlu O, et al. Correlation between upgrading of prostate biopsy and biochemical failure and unfavorable pathology after radical prostatectomy. Urol Int. 2009;83(2):146-50.
Ozden, C., Oztekin, C. V., Ugurlu, O., Gokkaya, S., Yaris, M., & Memis, A. (2009). Correlation between upgrading of prostate biopsy and biochemical failure and unfavorable pathology after radical prostatectomy. Urologia Internationalis, 83(2), 146-50. https://doi.org/10.1159/000230014
Ozden C, et al. Correlation Between Upgrading of Prostate Biopsy and Biochemical Failure and Unfavorable Pathology After Radical Prostatectomy. Urol Int. 2009;83(2):146-50. PubMed PMID: 19752607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between upgrading of prostate biopsy and biochemical failure and unfavorable pathology after radical prostatectomy. AU - Ozden,Cuneyt, AU - Oztekin,Cetin Volkan, AU - Ugurlu,Ozgur, AU - Gokkaya,Serkan, AU - Yaris,Mehmet, AU - Memis,Ali, Y1 - 2009/09/10/ PY - 2008/05/05/received PY - 2008/07/01/accepted PY - 2009/9/16/entrez PY - 2009/9/16/pubmed PY - 2009/12/16/medline SP - 146 EP - 50 JF - Urologia internationalis JO - Urol Int VL - 83 IS - 2 N2 - OBJECTIVE: To evaluate whether upgrading of the biopsy after radical prostatectomy (RP) affects disease outcome in terms of unfavorable pathology and biochemical failure. PATIENTS AND METHODS: We retrospectively evaluated the records of 174 patients who underwent RP. Prostate biopsy and RP specimen Gleason scores (GSs) and correlative clinical data were recorded, and a multivariate analysis was applied. RESULTS: Overall (138 patients), the disease of 69 men (50.0%) was upgraded, in 19 (13.8%) it was downgraded, and in 50 (36.2%) it had an identical biopsy and pathological GS. Accuracy rates were significantly higher for GS 8-10 compared to low GSs, with a concordance of 50.0 and 12.2%, respectively (p < 0.01). Multivariate analysis revealed the single independent prognostic factor for a non-organ-confined disease as a RP GS 8-10 (p = 0.035). The factors associated with a positive surgical margin were a biopsy GS 8-10 (p < 0.001) and the presence of biopsy score upgrading (p = 0.02). Biopsy GS >or=8 (p < 0.001) and presence of biopsy score upgrading (p = 0.009) were the two independent predictors of relapse after RP. CONCLUSION: This study demonstrated that biopsy upgrading was present in almost half of the patients who underwent RP and it was significantly related to positive surgical margins and biochemical relapse after RP. SN - 1423-0399 UR - https://www.unboundmedicine.com/medline/citation/19752607/Correlation_between_upgrading_of_prostate_biopsy_and_biochemical_failure_and_unfavorable_pathology_after_radical_prostatectomy_ L2 - https://www.karger.com?DOI=10.1159/000230014 DB - PRIME DP - Unbound Medicine ER -