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Review and update: genomic and molecular advances in sex determination and differentiation in small animals.
Reprod Domest Anim. 2009 Jul; 44 Suppl 2:40-6.RD

Abstract

Inherited disorders of sexual development are important to identify as a cause of inherited infertility or sterility in humans and animals. Investigation of these disorders in dogs and cats can identify new mutations, allowing us to eliminate inherited disorders from breeding populations, while contributing to the understanding of mammalian sexual development and differentiation. This review updates an overview of normal mammalian sexual development while discussing disorders of sexual development at three consecutive levels, as errors in sex chromosome constitution, gonadal sex determination or phenotypic sexual development. The molecular mechanisms controlling sexual development and current molecular methods to identify causative mutations are illustrated in three specific examples of abnormal sexual development reported in small animals: XX sex reversal, Persistent Mullerian Duct Syndrome and cryptorchidism. Identification of causative mutations and development of practical tests to identify carrier and affected animals will provide effective mechanisms to reduce the prevalence of these disorders in small animals.

Authors+Show Affiliations

Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. vnm1@cornell.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19754534

Citation

Meyers-Wallen, V N.. "Review and Update: Genomic and Molecular Advances in Sex Determination and Differentiation in Small Animals." Reproduction in Domestic Animals = Zuchthygiene, vol. 44 Suppl 2, 2009, pp. 40-6.
Meyers-Wallen VN. Review and update: genomic and molecular advances in sex determination and differentiation in small animals. Reprod Domest Anim. 2009;44 Suppl 2:40-6.
Meyers-Wallen, V. N. (2009). Review and update: genomic and molecular advances in sex determination and differentiation in small animals. Reproduction in Domestic Animals = Zuchthygiene, 44 Suppl 2, 40-6. https://doi.org/10.1111/j.1439-0531.2009.01433.x
Meyers-Wallen VN. Review and Update: Genomic and Molecular Advances in Sex Determination and Differentiation in Small Animals. Reprod Domest Anim. 2009;44 Suppl 2:40-6. PubMed PMID: 19754534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review and update: genomic and molecular advances in sex determination and differentiation in small animals. A1 - Meyers-Wallen,V N, PY - 2009/9/17/entrez PY - 2009/9/17/pubmed PY - 2010/3/17/medline SP - 40 EP - 6 JF - Reproduction in domestic animals = Zuchthygiene JO - Reprod. Domest. Anim. VL - 44 Suppl 2 N2 - Inherited disorders of sexual development are important to identify as a cause of inherited infertility or sterility in humans and animals. Investigation of these disorders in dogs and cats can identify new mutations, allowing us to eliminate inherited disorders from breeding populations, while contributing to the understanding of mammalian sexual development and differentiation. This review updates an overview of normal mammalian sexual development while discussing disorders of sexual development at three consecutive levels, as errors in sex chromosome constitution, gonadal sex determination or phenotypic sexual development. The molecular mechanisms controlling sexual development and current molecular methods to identify causative mutations are illustrated in three specific examples of abnormal sexual development reported in small animals: XX sex reversal, Persistent Mullerian Duct Syndrome and cryptorchidism. Identification of causative mutations and development of practical tests to identify carrier and affected animals will provide effective mechanisms to reduce the prevalence of these disorders in small animals. SN - 1439-0531 UR - https://www.unboundmedicine.com/medline/citation/19754534/Review_and_update:_genomic_and_molecular_advances_in_sex_determination_and_differentiation_in_small_animals_ L2 - https://doi.org/10.1111/j.1439-0531.2009.01433.x DB - PRIME DP - Unbound Medicine ER -