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A double-blind, placebo-controlled, randomized human study assessing the capacity of a novel galacto-oligosaccharide mixture in reducing travellers' diarrhoea.
Eur J Clin Nutr. 2010 Feb; 64(2):146-52.EJ

Abstract

BACKGROUND/OBJECTIVES

Prebiotics have attracted interest for their ability to positively affect the colonic microbiota composition, thus increasing resistance to infection and diarrhoeal disease. This study assessed the effectiveness of a prebiotic galacto-oligosaccharide mixture (B-GOS) on the severity and/or incidence of travellers' diarrhoea (TD) in healthy subjects.

SUBJECTS/METHODS

The study was a placebo-controlled, randomized, double blind of parallel design in 159 healthy volunteers, who travelled for minimum of 2 weeks to a country of low or high risk for TD. The investigational product was the B-GOS and the placebo was maltodextrin. Volunteers were randomized into groups with an equal probability of receiving either the prebiotic or placebo. The protocol comprised of a 1 week pre-holiday period recording bowel habit, while receiving intervention and the holiday period. Bowel habit included the number of bowel movements and average consistency of the stools as well as occurrence of abdominal discomfort, flatulence, bloating or vomiting. A clinical report was completed in the case of diarrhoeal incidence. A post-study questionnaire was also completed by all subjects on their return.

RESULTS

Results showed significant differences between the B-GOS and the placebo group in the incidence (P<0.05) and duration (P<0.05) of TD. Similar findings occurred on abdominal pain (P<0.05) and the overall quality of life assessment (P<0.05).

CONCLUSIONS

Consumption of the tested galacto-oligosaccharide mixture showed significant potential in preventing the incidence and symptoms of TD.

Authors+Show Affiliations

Department of Food Biosciences, The University of Reading, Reading, UK. a.drakoularakou@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19756029

Citation

Drakoularakou, A, et al. "A Double-blind, Placebo-controlled, Randomized Human Study Assessing the Capacity of a Novel Galacto-oligosaccharide Mixture in Reducing Travellers' Diarrhoea." European Journal of Clinical Nutrition, vol. 64, no. 2, 2010, pp. 146-52.
Drakoularakou A, Tzortzis G, Rastall RA, et al. A double-blind, placebo-controlled, randomized human study assessing the capacity of a novel galacto-oligosaccharide mixture in reducing travellers' diarrhoea. Eur J Clin Nutr. 2010;64(2):146-52.
Drakoularakou, A., Tzortzis, G., Rastall, R. A., & Gibson, G. R. (2010). A double-blind, placebo-controlled, randomized human study assessing the capacity of a novel galacto-oligosaccharide mixture in reducing travellers' diarrhoea. European Journal of Clinical Nutrition, 64(2), 146-52. https://doi.org/10.1038/ejcn.2009.120
Drakoularakou A, et al. A Double-blind, Placebo-controlled, Randomized Human Study Assessing the Capacity of a Novel Galacto-oligosaccharide Mixture in Reducing Travellers' Diarrhoea. Eur J Clin Nutr. 2010;64(2):146-52. PubMed PMID: 19756029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A double-blind, placebo-controlled, randomized human study assessing the capacity of a novel galacto-oligosaccharide mixture in reducing travellers' diarrhoea. AU - Drakoularakou,A, AU - Tzortzis,G, AU - Rastall,R A, AU - Gibson,G R, Y1 - 2009/09/16/ PY - 2009/9/17/entrez PY - 2009/9/17/pubmed PY - 2010/4/15/medline SP - 146 EP - 52 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 2 N2 - BACKGROUND/OBJECTIVES: Prebiotics have attracted interest for their ability to positively affect the colonic microbiota composition, thus increasing resistance to infection and diarrhoeal disease. This study assessed the effectiveness of a prebiotic galacto-oligosaccharide mixture (B-GOS) on the severity and/or incidence of travellers' diarrhoea (TD) in healthy subjects. SUBJECTS/METHODS: The study was a placebo-controlled, randomized, double blind of parallel design in 159 healthy volunteers, who travelled for minimum of 2 weeks to a country of low or high risk for TD. The investigational product was the B-GOS and the placebo was maltodextrin. Volunteers were randomized into groups with an equal probability of receiving either the prebiotic or placebo. The protocol comprised of a 1 week pre-holiday period recording bowel habit, while receiving intervention and the holiday period. Bowel habit included the number of bowel movements and average consistency of the stools as well as occurrence of abdominal discomfort, flatulence, bloating or vomiting. A clinical report was completed in the case of diarrhoeal incidence. A post-study questionnaire was also completed by all subjects on their return. RESULTS: Results showed significant differences between the B-GOS and the placebo group in the incidence (P<0.05) and duration (P<0.05) of TD. Similar findings occurred on abdominal pain (P<0.05) and the overall quality of life assessment (P<0.05). CONCLUSIONS: Consumption of the tested galacto-oligosaccharide mixture showed significant potential in preventing the incidence and symptoms of TD. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/19756029/full_citation L2 - http://dx.doi.org/10.1038/ejcn.2009.120 DB - PRIME DP - Unbound Medicine ER -