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Hepatitis C Virus-related chronic liver disease in elderly patients: an Italian cross-sectional study.
J Viral Hepat. 2010 May; 17(5):360-6.JV

Abstract

Chronic hepatitis C virus (HCV) infection has been poorly investigated in the elderly. The aim of this study was to identify the age-specific characteristics of chronic hepatitis C by comparing patients > or =65 years with those <65 years. A cross-sectional study was performed on data collected from consecutive outpatients referred for the first time to two tertiary outpatient clinics for liver diseases located in Bologna (Northern Italy) and Paola, Cosenza (Southern Italy) over a two-year period. A total of 560 anti-HCV and HCV-RNA positive patients were enrolled, of whom 174 (31%) were 65 years or older. The proportion of older patients was significantly higher in the Southern Italy centre, accounting for more than 40%. Comparison of younger and older groups showed that 51% patients > or =65 years had advanced liver disease (liver cirrhosis or hepatocellular carcinoma) compared with 26% younger patients (P < 0.0001). About half of the patients > or =65 years were not aware of their anti-HCV positive status, even if they tended to be more symptomatic than the younger group. By multivariate analysis, age > or = 65 years, alcohol consumption and diabetes were independently associated with advanced liver disease. Overall, 34 out of 174 patients (20%) > or =65 years had received antiviral treatment compared with 122 out of 386 (32%) younger patients (P = 0.003). Our results further emphasize the notion that chronic hepatitis C is becoming a disease of the elderly and that elderly patients with chronic HCV infection often have severe and underestimated disease.

Authors+Show Affiliations

Dipartimento di Medicina Clinica, Alma Mater Studiorum-Università di Bologna, Semeiotica Medica, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi, Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19758274

Citation

Gramenzi, A, et al. "Hepatitis C Virus-related Chronic Liver Disease in Elderly Patients: an Italian Cross-sectional Study." Journal of Viral Hepatitis, vol. 17, no. 5, 2010, pp. 360-6.
Gramenzi A, Conti F, Felline F, et al. Hepatitis C Virus-related chronic liver disease in elderly patients: an Italian cross-sectional study. J Viral Hepat. 2010;17(5):360-6.
Gramenzi, A., Conti, F., Felline, F., Cursaro, C., Riili, A., Salerno, M., Gitto, S., Micco, L., Scuteri, A., Andreone, P., & Bernardi, M. (2010). Hepatitis C Virus-related chronic liver disease in elderly patients: an Italian cross-sectional study. Journal of Viral Hepatitis, 17(5), 360-6. https://doi.org/10.1111/j.1365-2893.2009.01189.x
Gramenzi A, et al. Hepatitis C Virus-related Chronic Liver Disease in Elderly Patients: an Italian Cross-sectional Study. J Viral Hepat. 2010;17(5):360-6. PubMed PMID: 19758274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis C Virus-related chronic liver disease in elderly patients: an Italian cross-sectional study. AU - Gramenzi,A, AU - Conti,F, AU - Felline,F, AU - Cursaro,C, AU - Riili,A, AU - Salerno,M, AU - Gitto,S, AU - Micco,L, AU - Scuteri,A, AU - Andreone,P, AU - Bernardi,M, Y1 - 2009/09/16/ PY - 2009/9/18/entrez PY - 2009/9/18/pubmed PY - 2010/7/23/medline SP - 360 EP - 6 JF - Journal of viral hepatitis JO - J Viral Hepat VL - 17 IS - 5 N2 - Chronic hepatitis C virus (HCV) infection has been poorly investigated in the elderly. The aim of this study was to identify the age-specific characteristics of chronic hepatitis C by comparing patients > or =65 years with those <65 years. A cross-sectional study was performed on data collected from consecutive outpatients referred for the first time to two tertiary outpatient clinics for liver diseases located in Bologna (Northern Italy) and Paola, Cosenza (Southern Italy) over a two-year period. A total of 560 anti-HCV and HCV-RNA positive patients were enrolled, of whom 174 (31%) were 65 years or older. The proportion of older patients was significantly higher in the Southern Italy centre, accounting for more than 40%. Comparison of younger and older groups showed that 51% patients > or =65 years had advanced liver disease (liver cirrhosis or hepatocellular carcinoma) compared with 26% younger patients (P < 0.0001). About half of the patients > or =65 years were not aware of their anti-HCV positive status, even if they tended to be more symptomatic than the younger group. By multivariate analysis, age > or = 65 years, alcohol consumption and diabetes were independently associated with advanced liver disease. Overall, 34 out of 174 patients (20%) > or =65 years had received antiviral treatment compared with 122 out of 386 (32%) younger patients (P = 0.003). Our results further emphasize the notion that chronic hepatitis C is becoming a disease of the elderly and that elderly patients with chronic HCV infection often have severe and underestimated disease. SN - 1365-2893 UR - https://www.unboundmedicine.com/medline/citation/19758274/Hepatitis_C_Virus_related_chronic_liver_disease_in_elderly_patients:_an_Italian_cross_sectional_study_ L2 - https://doi.org/10.1111/j.1365-2893.2009.01189.x DB - PRIME DP - Unbound Medicine ER -