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Soy-protein consumption and kidney-related biomarkers among type 2 diabetics: a crossover, randomized clinical trial.
J Ren Nutr. 2009 Nov; 19(6):479-86.JR

Abstract

OBJECTIVE

Renal disease is a major problem among diabetic patients. The type of protein consumed may affect alterations in kidney-related biomarkers in these patients. This study sought to assess the effects of soy-protein consumption on renal-related markers among type 2 diabetic patients with nephropathy.

METHODS

A crossover, randomized clinical trial was conducted among 14 patients (10 men and 4 women). One diet contained 0.8 g/kg protein (70% animal and 30% vegetable proteins), and a similar diet contained the same amount of protein with 35% animal protein, 35% soy protein, and 30% other vegetable proteins. These two diets were prescribed in each phase of the trial for 7 weeks. There was a 4-week washout between the two phases of the study.

RESULTS

Consumption of soy protein reduced urinary urea nitrogen (-0.9 +/- 0.8 vs. 0.2 +/- 0.6 mg/dL, respectively, SD; P < .001), proteinuria (-78 +/- 37 vs. 42 +/- 39 mg/day, respectively, SD; P < .001), blood sodium (-2 +/- 0.04 vs. 2.0 +/- 0.06 mg/dL, respectively, SD; P < .01), and serum phosphorus (-0.03 +/- 0.2 vs. 0.2 +/- 0.3 mg/dL, respectively, SD; P < .01) compared with animal protein. Serum and urinary creatinine, blood urea nitrogen, serum calcium, and potassium levels were not significantly changed in soy-protein versus anima-protein consumption.

CONCLUSION

Soy-protein consumption reduces proteinuria in type 2 diabetes with nephropathy.

Authors+Show Affiliations

Department of Nutrition, School of Public Health, and Food Security and Nutrition Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. azadbakht@hlth.mui.ac.irNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19758824

Citation

Azadbakht, Leila, and Ahmad Esmaillzadeh. "Soy-protein Consumption and Kidney-related Biomarkers Among Type 2 Diabetics: a Crossover, Randomized Clinical Trial." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 19, no. 6, 2009, pp. 479-86.
Azadbakht L, Esmaillzadeh A. Soy-protein consumption and kidney-related biomarkers among type 2 diabetics: a crossover, randomized clinical trial. J Ren Nutr. 2009;19(6):479-86.
Azadbakht, L., & Esmaillzadeh, A. (2009). Soy-protein consumption and kidney-related biomarkers among type 2 diabetics: a crossover, randomized clinical trial. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 19(6), 479-86. https://doi.org/10.1053/j.jrn.2009.06.002
Azadbakht L, Esmaillzadeh A. Soy-protein Consumption and Kidney-related Biomarkers Among Type 2 Diabetics: a Crossover, Randomized Clinical Trial. J Ren Nutr. 2009;19(6):479-86. PubMed PMID: 19758824.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy-protein consumption and kidney-related biomarkers among type 2 diabetics: a crossover, randomized clinical trial. AU - Azadbakht,Leila, AU - Esmaillzadeh,Ahmad, Y1 - 2009/09/15/ PY - 2008/04/23/received PY - 2009/9/18/entrez PY - 2009/9/18/pubmed PY - 2010/1/21/medline SP - 479 EP - 86 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 19 IS - 6 N2 - OBJECTIVE: Renal disease is a major problem among diabetic patients. The type of protein consumed may affect alterations in kidney-related biomarkers in these patients. This study sought to assess the effects of soy-protein consumption on renal-related markers among type 2 diabetic patients with nephropathy. METHODS: A crossover, randomized clinical trial was conducted among 14 patients (10 men and 4 women). One diet contained 0.8 g/kg protein (70% animal and 30% vegetable proteins), and a similar diet contained the same amount of protein with 35% animal protein, 35% soy protein, and 30% other vegetable proteins. These two diets were prescribed in each phase of the trial for 7 weeks. There was a 4-week washout between the two phases of the study. RESULTS: Consumption of soy protein reduced urinary urea nitrogen (-0.9 +/- 0.8 vs. 0.2 +/- 0.6 mg/dL, respectively, SD; P < .001), proteinuria (-78 +/- 37 vs. 42 +/- 39 mg/day, respectively, SD; P < .001), blood sodium (-2 +/- 0.04 vs. 2.0 +/- 0.06 mg/dL, respectively, SD; P < .01), and serum phosphorus (-0.03 +/- 0.2 vs. 0.2 +/- 0.3 mg/dL, respectively, SD; P < .01) compared with animal protein. Serum and urinary creatinine, blood urea nitrogen, serum calcium, and potassium levels were not significantly changed in soy-protein versus anima-protein consumption. CONCLUSION: Soy-protein consumption reduces proteinuria in type 2 diabetes with nephropathy. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/19758824/Soy_protein_consumption_and_kidney_related_biomarkers_among_type_2_diabetics:_a_crossover_randomized_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(09)00153-8 DB - PRIME DP - Unbound Medicine ER -