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Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial.
Am J Clin Nutr. 2009 Nov; 90(5):1433-9.AJ

Abstract

BACKGROUND

Isoflavones are naturally occurring plant estrogens that are abundant in soy. Although purported to protect against bone loss, the efficacy of soy isoflavone supplementation in the prevention of osteoporosis in postmenopausal women remains controversial.

OBJECTIVE

Our aim was to test the effect of soy isoflavone supplementation on bone health.

DESIGN

A multicenter, randomized, double-blind, placebo-controlled 24-mo trial was conducted to assess the effects of daily supplementation with 80 or 120 mg of soy hypocotyl aglycone isoflavones plus calcium and vitamin D on bone changes in 403 postmenopausal women. Study subjects were tested annually and changes in whole-body and regional bone mineral density (BMD), bone mineral content (BMC), and T scores were assessed. Changes in serum biochemical markers of bone metabolism were also assessed.

RESULTS

After study site, soy intake, and pretreatment values were controlled for, subjects receiving a daily supplement with 120 mg soy isoflavones had a statistically significant smaller reduction in whole-body BMD than did the placebo group both at 1 y (P < 0.03) and at 2 y (P < 0.05) of treatment. Smaller decreases in whole-body BMD T score were observed among this group of women at 1 y (P < 0.03) but not at 2 y of treatment. When compared with the placebo, soy isoflavone supplementation had no effect on changes in regional BMD, BMC, T scores, or biochemical markers of bone metabolism.

CONCLUSION

Daily supplementation with 120 mg soy hypocotyl isoflavones reduces whole-body bone loss but does not slow bone loss at common fracture sites in healthy postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00665860.

Authors+Show Affiliations

US Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA. wwong@bcm.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

19759166

Citation

Wong, William W., et al. "Soy Isoflavone Supplementation and Bone Mineral Density in Menopausal Women: a 2-y Multicenter Clinical Trial." The American Journal of Clinical Nutrition, vol. 90, no. 5, 2009, pp. 1433-9.
Wong WW, Lewis RD, Steinberg FM, et al. Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial. Am J Clin Nutr. 2009;90(5):1433-9.
Wong, W. W., Lewis, R. D., Steinberg, F. M., Murray, M. J., Cramer, M. A., Amato, P., Young, R. L., Barnes, S., Ellis, K. J., Shypailo, R. J., Fraley, J. K., Konzelmann, K. L., Fischer, J. G., & Smith, E. O. (2009). Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial. The American Journal of Clinical Nutrition, 90(5), 1433-9. https://doi.org/10.3945/ajcn.2009.28001
Wong WW, et al. Soy Isoflavone Supplementation and Bone Mineral Density in Menopausal Women: a 2-y Multicenter Clinical Trial. Am J Clin Nutr. 2009;90(5):1433-9. PubMed PMID: 19759166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavone supplementation and bone mineral density in menopausal women: a 2-y multicenter clinical trial. AU - Wong,William W, AU - Lewis,Richard D, AU - Steinberg,Francene M, AU - Murray,Michael J, AU - Cramer,Margaret A, AU - Amato,Paula, AU - Young,Ronald L, AU - Barnes,Stephen, AU - Ellis,Kenneth J, AU - Shypailo,Roman J, AU - Fraley,J Kennard, AU - Konzelmann,Karen L, AU - Fischer,Joan G, AU - Smith,E O'Brian, Y1 - 2009/09/16/ PY - 2009/9/18/entrez PY - 2009/9/18/pubmed PY - 2010/1/7/medline SP - 1433 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 90 IS - 5 N2 - BACKGROUND: Isoflavones are naturally occurring plant estrogens that are abundant in soy. Although purported to protect against bone loss, the efficacy of soy isoflavone supplementation in the prevention of osteoporosis in postmenopausal women remains controversial. OBJECTIVE: Our aim was to test the effect of soy isoflavone supplementation on bone health. DESIGN: A multicenter, randomized, double-blind, placebo-controlled 24-mo trial was conducted to assess the effects of daily supplementation with 80 or 120 mg of soy hypocotyl aglycone isoflavones plus calcium and vitamin D on bone changes in 403 postmenopausal women. Study subjects were tested annually and changes in whole-body and regional bone mineral density (BMD), bone mineral content (BMC), and T scores were assessed. Changes in serum biochemical markers of bone metabolism were also assessed. RESULTS: After study site, soy intake, and pretreatment values were controlled for, subjects receiving a daily supplement with 120 mg soy isoflavones had a statistically significant smaller reduction in whole-body BMD than did the placebo group both at 1 y (P < 0.03) and at 2 y (P < 0.05) of treatment. Smaller decreases in whole-body BMD T score were observed among this group of women at 1 y (P < 0.03) but not at 2 y of treatment. When compared with the placebo, soy isoflavone supplementation had no effect on changes in regional BMD, BMC, T scores, or biochemical markers of bone metabolism. CONCLUSION: Daily supplementation with 120 mg soy hypocotyl isoflavones reduces whole-body bone loss but does not slow bone loss at common fracture sites in healthy postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00665860. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19759166/Soy_isoflavone_supplementation_and_bone_mineral_density_in_menopausal_women:_a_2_y_multicenter_clinical_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28001 DB - PRIME DP - Unbound Medicine ER -