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[The pathology of insulinoma and gastrinoma. The location, size, multicentricity, association with multiple endocrine type-I neoplasms and malignancy].
Dtsch Med Wochenschr. 1990 Sep 14; 115(37):1386-91.DM

Abstract

The pathology of insulinoma and gastrinoma was studied in 81 patients (31 men, 50 women, mean age 48.4 years) suffering from persistent hyperinsulinaemic hypoglycaemia, and in 44 patients (28 men, 16 women, mean age 48.5 years) with Zollinger-Ellison syndrome. Insulinomas were seen in the pancreas of all patients with persistent hyperinsulinaemic hypoglycaemia. In 70 of the 81 patients the insulinoma was solitary, whereas six patients had multiple insulinomas. In five patients with multiple endocrine neoplasia type I, multiple endocrine tumours of the pancreas were visible, only one of them in each case being an insulinoma. 75% of all insulinomas were less than 2 cm in size and 15% were malignant. 18 of the 44 Zollinger-Ellison syndrome patients also had multiple endocrine neoplasia type I. Nine of these patients presented with duodenal gastrinomas which were often multiple and smaller than 0.5 cm. The gastrinoma was located in the pancreas of one of the patients with multiple endocrine neoplasia, in two patients in lymph nodes, and no gastrinoma was identified in the specimens from six patients. 33% of the duodenal gastrinomas had metastasised. Solitary gastrinomas were found in all 26 patients with sporadic Zollinger-Ellison syndrome, 14 being located in the pancreas (diameter over 2 cm in eight cases) and ten in the duodenum (diameter less than 1 cm in seven cases). 16 of these gastrinomas were malignant.

Authors+Show Affiliations

Institut für Pathologie, Freie Universität Brüssel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

1976084

Citation

Donow, C, et al. "[The Pathology of Insulinoma and Gastrinoma. the Location, Size, Multicentricity, Association With Multiple Endocrine type-I Neoplasms and Malignancy]." Deutsche Medizinische Wochenschrift (1946), vol. 115, no. 37, 1990, pp. 1386-91.
Donow C, Pipeleers-Marichal M, Stamm B, et al. [The pathology of insulinoma and gastrinoma. The location, size, multicentricity, association with multiple endocrine type-I neoplasms and malignancy]. Dtsch Med Wochenschr. 1990;115(37):1386-91.
Donow, C., Pipeleers-Marichal, M., Stamm, B., Heitz, P. U., & Klöppel, G. (1990). [The pathology of insulinoma and gastrinoma. The location, size, multicentricity, association with multiple endocrine type-I neoplasms and malignancy]. Deutsche Medizinische Wochenschrift (1946), 115(37), 1386-91.
Donow C, et al. [The Pathology of Insulinoma and Gastrinoma. the Location, Size, Multicentricity, Association With Multiple Endocrine type-I Neoplasms and Malignancy]. Dtsch Med Wochenschr. 1990 Sep 14;115(37):1386-91. PubMed PMID: 1976084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The pathology of insulinoma and gastrinoma. The location, size, multicentricity, association with multiple endocrine type-I neoplasms and malignancy]. AU - Donow,C, AU - Pipeleers-Marichal,M, AU - Stamm,B, AU - Heitz,P U, AU - Klöppel,G, PY - 1990/9/14/pubmed PY - 1990/9/14/medline PY - 1990/9/14/entrez SP - 1386 EP - 91 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 115 IS - 37 N2 - The pathology of insulinoma and gastrinoma was studied in 81 patients (31 men, 50 women, mean age 48.4 years) suffering from persistent hyperinsulinaemic hypoglycaemia, and in 44 patients (28 men, 16 women, mean age 48.5 years) with Zollinger-Ellison syndrome. Insulinomas were seen in the pancreas of all patients with persistent hyperinsulinaemic hypoglycaemia. In 70 of the 81 patients the insulinoma was solitary, whereas six patients had multiple insulinomas. In five patients with multiple endocrine neoplasia type I, multiple endocrine tumours of the pancreas were visible, only one of them in each case being an insulinoma. 75% of all insulinomas were less than 2 cm in size and 15% were malignant. 18 of the 44 Zollinger-Ellison syndrome patients also had multiple endocrine neoplasia type I. Nine of these patients presented with duodenal gastrinomas which were often multiple and smaller than 0.5 cm. The gastrinoma was located in the pancreas of one of the patients with multiple endocrine neoplasia, in two patients in lymph nodes, and no gastrinoma was identified in the specimens from six patients. 33% of the duodenal gastrinomas had metastasised. Solitary gastrinomas were found in all 26 patients with sporadic Zollinger-Ellison syndrome, 14 being located in the pancreas (diameter over 2 cm in eight cases) and ten in the duodenum (diameter less than 1 cm in seven cases). 16 of these gastrinomas were malignant. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/1976084/[The_pathology_of_insulinoma_and_gastrinoma__The_location_size_multicentricity_association_with_multiple_endocrine_type_I_neoplasms_and_malignancy]_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1065168 DB - PRIME DP - Unbound Medicine ER -