Tags

Type your tag names separated by a space and hit enter

[Influence of electroacupuncture on hippocampal somatostatin (SS) and SS mRNA expression in chronic stress-induced depression rats].
Zhen Ci Yan Jiu. 2009 Jun; 34(3):175-9.ZC

Abstract

OBJECTIVE

To study the underlying mechanism of electroacupuncture (EA) in relieving depression.

METHODS

A total of 30 Wistar rats were randomly divided into normal control group (n=10), model group (n=10) and EA group (n=10). Depression model was established by lonely raising and chronic unpredictable mild stress for 21 days. EA (2 Hz, 1 mA) was applied to "Baihui" (GV 20) and "Sanyinjiao" (SP 6) for 20 min, once daily for 14 days. The expression (option density) of hippocampal somatostatin (SS) and SS mRNA was detected by using immunohistochemistry and reversed transcription-polymerase chain reaction (RT-PCR) techniques respectively.

RESULTS

Compared to normal control group, the crossing movement and rearing movement times of open-field test, and sucrose consumption in model group decreased significantly (P < 0.01), and hippocampal SS and SS mRNA expressions were downregulated remarkably (P < 0.05). Compared to model group, the crossing movement and rearing movement times in EA group increased considerably (P < 0.01), and hippocampal SS and SS mRNA expressions were upregulated remarkably (P < 0.05). No significant difference was found between EA and normal control groups in SS and SS mRNA expression.

CONCLUSION

EA can effectively improve depression rats' behavior activity and upregulate hippocampal SS and SS mRNA expression.

Authors+Show Affiliations

College of Chinese Medicine, Chongqing Medical University, Chongqing 401331, China. zyzy_178@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19761111

Citation

Zhu, Yi, et al. "[Influence of Electroacupuncture On Hippocampal Somatostatin (SS) and SS mRNA Expression in Chronic Stress-induced Depression Rats]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 34, no. 3, 2009, pp. 175-9.
Zhu Y, Bai CY, Zhuo LS, et al. [Influence of electroacupuncture on hippocampal somatostatin (SS) and SS mRNA expression in chronic stress-induced depression rats]. Zhen Ci Yan Jiu. 2009;34(3):175-9.
Zhu, Y., Bai, C. Y., Zhuo, L. S., & Feng, W. Q. (2009). [Influence of electroacupuncture on hippocampal somatostatin (SS) and SS mRNA expression in chronic stress-induced depression rats]. Zhen Ci Yan Jiu = Acupuncture Research, 34(3), 175-9.
Zhu Y, et al. [Influence of Electroacupuncture On Hippocampal Somatostatin (SS) and SS mRNA Expression in Chronic Stress-induced Depression Rats]. Zhen Ci Yan Jiu. 2009;34(3):175-9. PubMed PMID: 19761111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of electroacupuncture on hippocampal somatostatin (SS) and SS mRNA expression in chronic stress-induced depression rats]. AU - Zhu,Yi, AU - Bai,Chun-yan, AU - Zhuo,Lian-shi, AU - Feng,Wen-qi, PY - 2009/9/19/entrez PY - 2009/9/19/pubmed PY - 2009/10/9/medline SP - 175 EP - 9 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 34 IS - 3 N2 - OBJECTIVE: To study the underlying mechanism of electroacupuncture (EA) in relieving depression. METHODS: A total of 30 Wistar rats were randomly divided into normal control group (n=10), model group (n=10) and EA group (n=10). Depression model was established by lonely raising and chronic unpredictable mild stress for 21 days. EA (2 Hz, 1 mA) was applied to "Baihui" (GV 20) and "Sanyinjiao" (SP 6) for 20 min, once daily for 14 days. The expression (option density) of hippocampal somatostatin (SS) and SS mRNA was detected by using immunohistochemistry and reversed transcription-polymerase chain reaction (RT-PCR) techniques respectively. RESULTS: Compared to normal control group, the crossing movement and rearing movement times of open-field test, and sucrose consumption in model group decreased significantly (P < 0.01), and hippocampal SS and SS mRNA expressions were downregulated remarkably (P < 0.05). Compared to model group, the crossing movement and rearing movement times in EA group increased considerably (P < 0.01), and hippocampal SS and SS mRNA expressions were upregulated remarkably (P < 0.05). No significant difference was found between EA and normal control groups in SS and SS mRNA expression. CONCLUSION: EA can effectively improve depression rats' behavior activity and upregulate hippocampal SS and SS mRNA expression. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/19761111/[Influence_of_electroacupuncture_on_hippocampal_somatostatin__SS__and_SS_mRNA_expression_in_chronic_stress_induced_depression_rats]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -