Tags

Type your tag names separated by a space and hit enter

Oxidant/antioxidant status in recurrent aphthous stomatitis.
Oral Dis. 2009 Oct; 15(7):512-5.OD

Abstract

OBJECTIVE

Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae, and oxidative stress presumably contributes to its pathogenesis. The study was performed to evaluate the involvement of oxidant toxicity in this disorder.

METHODS

Patients with RAS (n = 26) and age- and sex-matched healthy control subjects (n = 20) were included in this study. Following an overnight fast, blood specimens were obtained. Plasma malondialdehyde concentrations and erythrocytes glutathione peroxidase activities were determined. Also, plasma vitamin E and selenium levels were detected. Mann-Whitney U-test was performed for statistical evaluation.

RESULTS

Oxidative stress was confirmed by the significant elevation in plasma malondialdehyde levels and by the significant decrease in glutathione peroxidase activities, vitamin E and selenium levels (P < 0.001).

CONCLUSIONS

Our results indicated that lipid peroxidation and the inadequacy of the defense system seem to play a crucial role in the pathogenesis of recurrent aphthous stomatitis.

Authors+Show Affiliations

Departments of Biochemistry and Dermatology, Baskent University, Alanya Hospital, Yunus Emre Street No:1, 07400 Alanya/Antalya, Turkey. serapa@baskent-aln.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19761497

Citation

Arikan, S, et al. "Oxidant/antioxidant Status in Recurrent Aphthous Stomatitis." Oral Diseases, vol. 15, no. 7, 2009, pp. 512-5.
Arikan S, Durusoy C, Akalin N, et al. Oxidant/antioxidant status in recurrent aphthous stomatitis. Oral Dis. 2009;15(7):512-5.
Arikan, S., Durusoy, C., Akalin, N., Haberal, A., & Seckin, D. (2009). Oxidant/antioxidant status in recurrent aphthous stomatitis. Oral Diseases, 15(7), 512-5. https://doi.org/10.1111/j.1601-0825.2009.01580.x
Arikan S, et al. Oxidant/antioxidant Status in Recurrent Aphthous Stomatitis. Oral Dis. 2009;15(7):512-5. PubMed PMID: 19761497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidant/antioxidant status in recurrent aphthous stomatitis. AU - Arikan,S, AU - Durusoy,C, AU - Akalin,N, AU - Haberal,A, AU - Seckin,D, PY - 2009/9/19/entrez PY - 2009/9/19/pubmed PY - 2009/12/16/medline SP - 512 EP - 5 JF - Oral diseases JO - Oral Dis VL - 15 IS - 7 N2 - OBJECTIVE: Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae, and oxidative stress presumably contributes to its pathogenesis. The study was performed to evaluate the involvement of oxidant toxicity in this disorder. METHODS: Patients with RAS (n = 26) and age- and sex-matched healthy control subjects (n = 20) were included in this study. Following an overnight fast, blood specimens were obtained. Plasma malondialdehyde concentrations and erythrocytes glutathione peroxidase activities were determined. Also, plasma vitamin E and selenium levels were detected. Mann-Whitney U-test was performed for statistical evaluation. RESULTS: Oxidative stress was confirmed by the significant elevation in plasma malondialdehyde levels and by the significant decrease in glutathione peroxidase activities, vitamin E and selenium levels (P < 0.001). CONCLUSIONS: Our results indicated that lipid peroxidation and the inadequacy of the defense system seem to play a crucial role in the pathogenesis of recurrent aphthous stomatitis. SN - 1601-0825 UR - https://www.unboundmedicine.com/medline/citation/19761497/Oxidant/antioxidant_status_in_recurrent_aphthous_stomatitis_ L2 - https://doi.org/10.1111/j.1601-0825.2009.01580.x DB - PRIME DP - Unbound Medicine ER -