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Discrimination between Sjögren's and non-Sjögren's sicca syndrome by sialoscintigraphy and antibodies against alpha-fodrin and Ro/La autoantigens.
J Int Med Res. 2009 Jul-Aug; 37(4):1088-96.JI

Abstract

Both Sjögren's syndrome (SS) and non-Sjögren's syndrome (NSS) can present with the sicca symptoms of dry eyes and a dry mouth but they are distinct pathological entities that require diagnostic discrimination. This study included 82 sicca syndrome patients and examined the ability of sialoscintigraphy and antibodies against the autoantigens alpha-fodrin, Ro and La to discriminate between SS and NSS. A total of 30.8% of SS patients compared with 58.8% of NSS patients were alpha-fodrin positive. The prevalence of Ro positivity was 69.4% for SS patients compared with 0% for NSS patients. The prevalence of La positivity was 52.4% for SS compared with 0% for NSS patients. Sialoscintigraphy showed that more NSS patients had grade III salivary gland impairment compared with SS patients (64.7% versus 19.4%). These data suggest that using sialoscintigraphy in combination with measuring the levels of serum alpha-fodrin, Ro and La might be useful for SS and NSS discrimination.

Authors+Show Affiliations

Department of Allergy, Immunology and Rheumatology, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19761691

Citation

Chen, K-S, et al. "Discrimination Between Sjögren's and non-Sjögren's Sicca Syndrome By Sialoscintigraphy and Antibodies Against Alpha-fodrin and Ro/La Autoantigens." The Journal of International Medical Research, vol. 37, no. 4, 2009, pp. 1088-96.
Chen KS, Jiang MC, Li CJ, et al. Discrimination between Sjögren's and non-Sjögren's sicca syndrome by sialoscintigraphy and antibodies against alpha-fodrin and Ro/La autoantigens. J Int Med Res. 2009;37(4):1088-96.
Chen, K. S., Jiang, M. C., Li, C. J., Liu, O. K., & Tsai, C. S. (2009). Discrimination between Sjögren's and non-Sjögren's sicca syndrome by sialoscintigraphy and antibodies against alpha-fodrin and Ro/La autoantigens. The Journal of International Medical Research, 37(4), 1088-96.
Chen KS, et al. Discrimination Between Sjögren's and non-Sjögren's Sicca Syndrome By Sialoscintigraphy and Antibodies Against Alpha-fodrin and Ro/La Autoantigens. J Int Med Res. 2009 Jul-Aug;37(4):1088-96. PubMed PMID: 19761691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discrimination between Sjögren's and non-Sjögren's sicca syndrome by sialoscintigraphy and antibodies against alpha-fodrin and Ro/La autoantigens. AU - Chen,K-S, AU - Jiang,M-C, AU - Li,C-J, AU - Liu,O-K, AU - Tsai,C-S S, PY - 2009/9/19/entrez PY - 2009/9/19/pubmed PY - 2009/10/23/medline SP - 1088 EP - 96 JF - The Journal of international medical research JO - J Int Med Res VL - 37 IS - 4 N2 - Both Sjögren's syndrome (SS) and non-Sjögren's syndrome (NSS) can present with the sicca symptoms of dry eyes and a dry mouth but they are distinct pathological entities that require diagnostic discrimination. This study included 82 sicca syndrome patients and examined the ability of sialoscintigraphy and antibodies against the autoantigens alpha-fodrin, Ro and La to discriminate between SS and NSS. A total of 30.8% of SS patients compared with 58.8% of NSS patients were alpha-fodrin positive. The prevalence of Ro positivity was 69.4% for SS patients compared with 0% for NSS patients. The prevalence of La positivity was 52.4% for SS compared with 0% for NSS patients. Sialoscintigraphy showed that more NSS patients had grade III salivary gland impairment compared with SS patients (64.7% versus 19.4%). These data suggest that using sialoscintigraphy in combination with measuring the levels of serum alpha-fodrin, Ro and La might be useful for SS and NSS discrimination. SN - 0300-0605 UR - https://www.unboundmedicine.com/medline/citation/19761691/Discrimination_between_Sjögren's_and_non_Sjögren's_sicca_syndrome_by_sialoscintigraphy_and_antibodies_against_alpha_fodrin_and_Ro/La_autoantigens_ L2 - https://journals.sagepub.com/doi/10.1177/147323000903700413?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -