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Vitamin D status and the risk of cardiovascular disease death.
Am J Epidemiol. 2009 Oct 15; 170(8):1032-9.AJ

Abstract

Accumulating evidence suggests that inadequate vitamin D levels may predispose people to chronic diseases. The authors aimed to investigate whether serum 25-hydroxyvitamin D (25(OH)D) level predicts mortality from cardiovascular disease (CVD). The study was based on the Mini-Finland Health Survey and included 6,219 men and women aged > or =30 years who were free from CVD at baseline (1978-1980). During follow-up through 2006, 640 coronary disease deaths and 293 cerebrovascular disease deaths were identified. Levels of 25(OH)D were determined from serum collected at baseline. Cox's proportional hazards model was used to assess the association between 25(OH)D and risk of CVD death. After adjustment for potential confounders, the hazard ratio for total CVD death was 0.76 (95% confidence interval (95% CI): 0.60, 0.95) for the highest quintile of 25(OH)D level versus the lowest. The association was evident for cerebrovascular death (hazard ratio = 0.48, 95% CI: 0.31, 0.75) but not coronary death (hazard ratio = 0.91, 95% CI: 0.70, 1.18). A low vitamin D level may be associated with higher risk of a fatal CVD event, particularly cerebrovascular death. These findings need to be replicated in other populations. To demonstrate a causal link between vitamin D and CVD, randomized controlled trials are required.

Authors+Show Affiliations

National Institute for Health and Welfare, Helsinki, Finland. annamari.kilkkinen@thl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19762371

Citation

Kilkkinen, Annamari, et al. "Vitamin D Status and the Risk of Cardiovascular Disease Death." American Journal of Epidemiology, vol. 170, no. 8, 2009, pp. 1032-9.
Kilkkinen A, Knekt P, Aro A, et al. Vitamin D status and the risk of cardiovascular disease death. Am J Epidemiol. 2009;170(8):1032-9.
Kilkkinen, A., Knekt, P., Aro, A., Rissanen, H., Marniemi, J., Heliövaara, M., Impivaara, O., & Reunanen, A. (2009). Vitamin D status and the risk of cardiovascular disease death. American Journal of Epidemiology, 170(8), 1032-9. https://doi.org/10.1093/aje/kwp227
Kilkkinen A, et al. Vitamin D Status and the Risk of Cardiovascular Disease Death. Am J Epidemiol. 2009 Oct 15;170(8):1032-9. PubMed PMID: 19762371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status and the risk of cardiovascular disease death. AU - Kilkkinen,Annamari, AU - Knekt,Paul, AU - Aro,Antti, AU - Rissanen,Harri, AU - Marniemi,Jukka, AU - Heliövaara,Markku, AU - Impivaara,Olli, AU - Reunanen,Antti, Y1 - 2009/09/17/ PY - 2009/9/19/entrez PY - 2009/9/19/pubmed PY - 2009/10/21/medline SP - 1032 EP - 9 JF - American journal of epidemiology JO - Am J Epidemiol VL - 170 IS - 8 N2 - Accumulating evidence suggests that inadequate vitamin D levels may predispose people to chronic diseases. The authors aimed to investigate whether serum 25-hydroxyvitamin D (25(OH)D) level predicts mortality from cardiovascular disease (CVD). The study was based on the Mini-Finland Health Survey and included 6,219 men and women aged > or =30 years who were free from CVD at baseline (1978-1980). During follow-up through 2006, 640 coronary disease deaths and 293 cerebrovascular disease deaths were identified. Levels of 25(OH)D were determined from serum collected at baseline. Cox's proportional hazards model was used to assess the association between 25(OH)D and risk of CVD death. After adjustment for potential confounders, the hazard ratio for total CVD death was 0.76 (95% confidence interval (95% CI): 0.60, 0.95) for the highest quintile of 25(OH)D level versus the lowest. The association was evident for cerebrovascular death (hazard ratio = 0.48, 95% CI: 0.31, 0.75) but not coronary death (hazard ratio = 0.91, 95% CI: 0.70, 1.18). A low vitamin D level may be associated with higher risk of a fatal CVD event, particularly cerebrovascular death. These findings need to be replicated in other populations. To demonstrate a causal link between vitamin D and CVD, randomized controlled trials are required. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/19762371/Vitamin_D_status_and_the_risk_of_cardiovascular_disease_death_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwp227 DB - PRIME DP - Unbound Medicine ER -