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Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals.
Cell Biochem Funct. 2009 Dec; 27(8):568-77.CB

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is important for folate and homocysteine (Hcy) metabolism. MTHFR 677C->T and 1298A->C MTHFR are two most common mutations which can affect folate and total homocysteine (tHcy) status. This study was designed to determine the rate of MTHFR 677C->T and 1298A->C mutations, and their influence on serum folate, Hcy and vitamin B12 status and the reference intervals in 402 healthy Turkish adults. The rate of MTHFR 677C->T or 1298A->C mutations was 50.7% or 54.7%, respectively. The MTHFR 677C->T mutation-specific reference intervals for serum folate and tHcy were characterized by marked shifts in their upper limits. In homozygote subjects for MTHFR 677C->T serum folate concentration was lower and serum tHcy concentration was higher than those in the wild genotype; all subjects had lower serum folate and 54% of the subjects had higher tHcy concentrations than the cutoff values of <or=10 nmol/L and >or=12 micromol/L, respectively. Serum vitamin B12 status was similar in all genotypes. Serum tHcy concentrations were inversely correlated with serum folate and vitamin B12 concentrations in all genotypes. These data show that the rate of MTHFR 677C->T and 1298A->C mutations is very high in Turks and serum folate and tHcy status are impaired by these mutations.

Authors+Show Affiliations

Department of Biochemistry, Uludag University Medical School, Bursa, Turkey. yozarda@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19764044

Citation

Ozarda, Yesim, et al. "Rate of T Alleles and TT Genotype at MTHFR 677C->T Locus or C Alleles and CC Genotype at MTHFR 1298A->C Locus Among Healthy Subjects in Turkey: Impact On Homocysteine and Folic Acid Status and Reference Intervals." Cell Biochemistry and Function, vol. 27, no. 8, 2009, pp. 568-77.
Ozarda Y, Sucu DK, Hizli B, et al. Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals. Cell Biochem Funct. 2009;27(8):568-77.
Ozarda, Y., Sucu, D. K., Hizli, B., & Aslan, D. (2009). Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals. Cell Biochemistry and Function, 27(8), 568-77. https://doi.org/10.1002/cbf.1610
Ozarda Y, et al. Rate of T Alleles and TT Genotype at MTHFR 677C->T Locus or C Alleles and CC Genotype at MTHFR 1298A->C Locus Among Healthy Subjects in Turkey: Impact On Homocysteine and Folic Acid Status and Reference Intervals. Cell Biochem Funct. 2009;27(8):568-77. PubMed PMID: 19764044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: impact on homocysteine and folic acid status and reference intervals. AU - Ozarda,Yesim, AU - Sucu,Derya Kaynak, AU - Hizli,Banu, AU - Aslan,Diler, PY - 2009/9/19/entrez PY - 2009/9/19/pubmed PY - 2010/2/23/medline SP - 568 EP - 77 JF - Cell biochemistry and function JO - Cell Biochem. Funct. VL - 27 IS - 8 N2 - Methylenetetrahydrofolate reductase (MTHFR) is important for folate and homocysteine (Hcy) metabolism. MTHFR 677C->T and 1298A->C MTHFR are two most common mutations which can affect folate and total homocysteine (tHcy) status. This study was designed to determine the rate of MTHFR 677C->T and 1298A->C mutations, and their influence on serum folate, Hcy and vitamin B12 status and the reference intervals in 402 healthy Turkish adults. The rate of MTHFR 677C->T or 1298A->C mutations was 50.7% or 54.7%, respectively. The MTHFR 677C->T mutation-specific reference intervals for serum folate and tHcy were characterized by marked shifts in their upper limits. In homozygote subjects for MTHFR 677C->T serum folate concentration was lower and serum tHcy concentration was higher than those in the wild genotype; all subjects had lower serum folate and 54% of the subjects had higher tHcy concentrations than the cutoff values of <or=10 nmol/L and >or=12 micromol/L, respectively. Serum vitamin B12 status was similar in all genotypes. Serum tHcy concentrations were inversely correlated with serum folate and vitamin B12 concentrations in all genotypes. These data show that the rate of MTHFR 677C->T and 1298A->C mutations is very high in Turks and serum folate and tHcy status are impaired by these mutations. SN - 1099-0844 UR - https://www.unboundmedicine.com/medline/citation/19764044/Rate_of_T_alleles_and_TT_genotype_at_MTHFR_677C_>T_locus_or_C_alleles_and_CC_genotype_at_MTHFR_1298A_>C_locus_among_healthy_subjects_in_Turkey:_impact_on_homocysteine_and_folic_acid_status_and_reference_intervals_ L2 - https://doi.org/10.1002/cbf.1610 DB - PRIME DP - Unbound Medicine ER -