[Long-term histological outcome for the larynx after Gore-Tex medialization thyroplasty].Nihon Jibiinkoka Gakkai Kaiho. 2009 Aug; 112(8):623-7.NJ
We studied the long-term histological response of the human larynx to Gore-Tex implant and evaluated whether its biocompatibility.
Retrospective histological study.
We conducted medialization laryngoplasty with expanded polytetrafluoroethylene (ePTEE or Gore-Tex) in a patient with vocal-fold paralysis. A strip of Gore-Tex was folded several times and inserted into the pocket preserving the inner perichondrium through a thyroid cartilage window. The patient died 12 months later and we histologically analyzed the larynx.
No evidence was seen of foreign body granuloma, migration, extrusion, or infection. A modest inflammatory response with a fibrous capsule was present around implants. We confirmed the infiltration of abundant collagen and numerous fibroblasts into the microporous implant structure.
Histological examination results suggest that Gore-Tex implants are safe and biocompatible with the human larynx. A slight inflammatory response and infiltration of fibrous tissue into the implant itself demonstrated that Gore-Tex implants are immunologically well tolerated.