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[Long-term histological outcome for the larynx after Gore-Tex medialization thyroplasty].
Nihon Jibiinkoka Gakkai Kaiho. 2009 Aug; 112(8):623-7.NJ

Abstract

OBJECTIVES

We studied the long-term histological response of the human larynx to Gore-Tex implant and evaluated whether its biocompatibility.

STUDY DESIGN

Retrospective histological study.

METHODS

We conducted medialization laryngoplasty with expanded polytetrafluoroethylene (ePTEE or Gore-Tex) in a patient with vocal-fold paralysis. A strip of Gore-Tex was folded several times and inserted into the pocket preserving the inner perichondrium through a thyroid cartilage window. The patient died 12 months later and we histologically analyzed the larynx.

RESULTS

No evidence was seen of foreign body granuloma, migration, extrusion, or infection. A modest inflammatory response with a fibrous capsule was present around implants. We confirmed the infiltration of abundant collagen and numerous fibroblasts into the microporous implant structure.

CONCLUSION

Histological examination results suggest that Gore-Tex implants are safe and biocompatible with the human larynx. A slight inflammatory response and infiltration of fibrous tissue into the implant itself demonstrated that Gore-Tex implants are immunologically well tolerated.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, Mita Hospital International University of Health & Welfare, Tokyo.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

19764545

Citation

Sasai, Hisanori, et al. "[Long-term Histological Outcome for the Larynx After Gore-Tex Medialization Thyroplasty]." Nihon Jibiinkoka Gakkai Kaiho, vol. 112, no. 8, 2009, pp. 623-7.
Sasai H, Watanabe Y, Miyahara H. [Long-term histological outcome for the larynx after Gore-Tex medialization thyroplasty]. Nihon Jibiinkoka Gakkai Kaiho. 2009;112(8):623-7.
Sasai, H., Watanabe, Y., & Miyahara, H. (2009). [Long-term histological outcome for the larynx after Gore-Tex medialization thyroplasty]. Nihon Jibiinkoka Gakkai Kaiho, 112(8), 623-7.
Sasai H, Watanabe Y, Miyahara H. [Long-term Histological Outcome for the Larynx After Gore-Tex Medialization Thyroplasty]. Nihon Jibiinkoka Gakkai Kaiho. 2009;112(8):623-7. PubMed PMID: 19764545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Long-term histological outcome for the larynx after Gore-Tex medialization thyroplasty]. AU - Sasai,Hisanori, AU - Watanabe,Yusuke, AU - Miyahara,Hiroshi, PY - 2009/9/22/entrez PY - 2009/9/22/pubmed PY - 2009/11/18/medline SP - 623 EP - 7 JF - Nihon Jibiinkoka Gakkai kaiho JO - Nihon Jibiinkoka Gakkai Kaiho VL - 112 IS - 8 N2 - OBJECTIVES: We studied the long-term histological response of the human larynx to Gore-Tex implant and evaluated whether its biocompatibility. STUDY DESIGN: Retrospective histological study. METHODS: We conducted medialization laryngoplasty with expanded polytetrafluoroethylene (ePTEE or Gore-Tex) in a patient with vocal-fold paralysis. A strip of Gore-Tex was folded several times and inserted into the pocket preserving the inner perichondrium through a thyroid cartilage window. The patient died 12 months later and we histologically analyzed the larynx. RESULTS: No evidence was seen of foreign body granuloma, migration, extrusion, or infection. A modest inflammatory response with a fibrous capsule was present around implants. We confirmed the infiltration of abundant collagen and numerous fibroblasts into the microporous implant structure. CONCLUSION: Histological examination results suggest that Gore-Tex implants are safe and biocompatible with the human larynx. A slight inflammatory response and infiltration of fibrous tissue into the implant itself demonstrated that Gore-Tex implants are immunologically well tolerated. SN - 0030-6622 UR - https://www.unboundmedicine.com/medline/citation/19764545/[Long_term_histological_outcome_for_the_larynx_after_Gore_Tex_medialization_thyroplasty]_ L2 - http://www.medicalonline.jp/meteo_linkout.php?issn=0030-6622&volume=112&issue=8&spage=623 DB - PRIME DP - Unbound Medicine ER -