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Depression and the cardiovascular system: increasing evidence of a link and therapeutic implications.
Expert Rev Cardiovasc Ther. 2009 Sep; 7(9):1123-47.ER

Abstract

This review explores the epidemiological evidence for the relationship between depression and cardiovascular disease from a mechanistic standpoint. It is important to examine the biological, behavioral and social mechanisms to improve outcomes for depressed cardiac patients. A number of plausible biobehavioral mechanisms linking depression and cardiovascular disease have been identified. Tricyclic antidepressants have various effects on the cardiovascular system, while selective serotonin reuptake inhibitors are not associated with adverse cardiac effects and should, therefore, be the preferred choice for the treatment of most patients with comorbid depression and cardiovascular disease.

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    Authors+Show Affiliations

    Marano G
    Department of Neuroscience, Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Rome, Italy.
    Harnic D
    No affiliation info available
    Lotrionte M
    No affiliation info available
    Biondi-Zoccai G
    No affiliation info available
    Abbate A
    No affiliation info available
    Romagnoli E
    No affiliation info available
    Mazza M
    No affiliation info available

    MeSH

    Antidepressive AgentsAntidepressive Agents, TricyclicCardiovascular DiseasesClinical Trials as TopicDepressive DisorderHumansSerotonin Uptake Inhibitors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19764865

    Citation

    Marano, Giuseppe, et al. "Depression and the Cardiovascular System: Increasing Evidence of a Link and Therapeutic Implications." Expert Review of Cardiovascular Therapy, vol. 7, no. 9, 2009, pp. 1123-47.
    Marano G, Harnic D, Lotrionte M, et al. Depression and the cardiovascular system: increasing evidence of a link and therapeutic implications. Expert Rev Cardiovasc Ther. 2009;7(9):1123-47.
    Marano, G., Harnic, D., Lotrionte, M., Biondi-Zoccai, G., Abbate, A., Romagnoli, E., & Mazza, M. (2009). Depression and the cardiovascular system: increasing evidence of a link and therapeutic implications. Expert Review of Cardiovascular Therapy, 7(9), 1123-47. https://doi.org/10.1586/erc.09.78
    Marano G, et al. Depression and the Cardiovascular System: Increasing Evidence of a Link and Therapeutic Implications. Expert Rev Cardiovasc Ther. 2009;7(9):1123-47. PubMed PMID: 19764865.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Depression and the cardiovascular system: increasing evidence of a link and therapeutic implications. AU - Marano,Giuseppe, AU - Harnic,Desiree, AU - Lotrionte,Marzia, AU - Biondi-Zoccai,Giuseppe, AU - Abbate,Antonio, AU - Romagnoli,Enrico, AU - Mazza,Marianna, PY - 2009/9/22/entrez PY - 2009/9/22/pubmed PY - 2009/12/22/medline SP - 1123 EP - 47 JF - Expert review of cardiovascular therapy JO - Expert Rev Cardiovasc Ther VL - 7 IS - 9 N2 - This review explores the epidemiological evidence for the relationship between depression and cardiovascular disease from a mechanistic standpoint. It is important to examine the biological, behavioral and social mechanisms to improve outcomes for depressed cardiac patients. A number of plausible biobehavioral mechanisms linking depression and cardiovascular disease have been identified. Tricyclic antidepressants have various effects on the cardiovascular system, while selective serotonin reuptake inhibitors are not associated with adverse cardiac effects and should, therefore, be the preferred choice for the treatment of most patients with comorbid depression and cardiovascular disease. SN - 1744-8344 UR - https://www.unboundmedicine.com/medline/citation/19764865/Depression_and_the_cardiovascular_system:_increasing_evidence_of_a_link_and_therapeutic_implications_ L2 - http://www.tandfonline.com/doi/full/10.1586/erc.09.78 DB - PRIME DP - Unbound Medicine ER -