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[A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever].
Zhonghua Nei Ke Za Zhi 1990; 29(3):138-40, 188ZN

Abstract

Plasma concentrations of Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were dynamically measured with radioimmunoassay in 30 patients of epidemic hemorrhagic fever (EHF). It was found that the levels plasma TXB2 significantly increased and 6-keto-PGF1 alpha decreased in EHF patients as compared with those in controls. The more severe the patient's condition, the higher the level of TXB2 and the lower the level of 6-keto-PGF1 alpha. The ratio of TXB2/6-keto-PGF1 alpha was parallel with the severity of the patient's condition. Plasma TXB and TXB2/6-keto-PGF1 alpha ratio increased significantly in the hemorrhagic and shock group, while 6-keto-PGF1 alpha decreased significantly in the shock group. The results showed that there is a distinct imbalance of TXA2-PGI2 mediated through the increase of TXA2 and decrease of PGI2 in EHF. The imbalance of TXA2-PGI2 participates in the pathogenesis and pathophysiology of hemorrhage, shock and renal dysfunction.

Authors+Show Affiliations

Wang GQ
Department of Infectious Diseases, First Affiliated Hospital, Harbin Medical University.
Zou ZZ
No affiliation info available
Yu DP
No affiliation info available

MeSH

6-Ketoprostaglandin F1 alphaAdultAgedHemorrhagic Fever with Renal SyndromeHumansMiddle AgedThromboxane B2

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

1976492

Citation

Wang, G Q., et al. "[A Study of the Role of Plasma Thromboxane B2 and 6-keto-prostaglandin F1 Alpha in Epidemic Hemorrhagic Fever]." Zhonghua Nei Ke Za Zhi, vol. 29, no. 3, 1990, pp. 138-40, 188.
Wang GQ, Zou ZZ, Yu DP. [A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever]. Zhonghua Nei Ke Za Zhi. 1990;29(3):138-40, 188.
Wang, G. Q., Zou, Z. Z., & Yu, D. P. (1990). [A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever]. Zhonghua Nei Ke Za Zhi, 29(3), pp. 138-40, 188.
Wang GQ, Zou ZZ, Yu DP. [A Study of the Role of Plasma Thromboxane B2 and 6-keto-prostaglandin F1 Alpha in Epidemic Hemorrhagic Fever]. Zhonghua Nei Ke Za Zhi. 1990;29(3):138-40, 188. PubMed PMID: 1976492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever]. AU - Wang,G Q, AU - Zou,Z Z, AU - Yu,D P, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 138-40, 188 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 29 IS - 3 N2 - Plasma concentrations of Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were dynamically measured with radioimmunoassay in 30 patients of epidemic hemorrhagic fever (EHF). It was found that the levels plasma TXB2 significantly increased and 6-keto-PGF1 alpha decreased in EHF patients as compared with those in controls. The more severe the patient's condition, the higher the level of TXB2 and the lower the level of 6-keto-PGF1 alpha. The ratio of TXB2/6-keto-PGF1 alpha was parallel with the severity of the patient's condition. Plasma TXB and TXB2/6-keto-PGF1 alpha ratio increased significantly in the hemorrhagic and shock group, while 6-keto-PGF1 alpha decreased significantly in the shock group. The results showed that there is a distinct imbalance of TXA2-PGI2 mediated through the increase of TXA2 and decrease of PGI2 in EHF. The imbalance of TXA2-PGI2 participates in the pathogenesis and pathophysiology of hemorrhage, shock and renal dysfunction. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/1976492/[A_study_of_the_role_of_plasma_thromboxane_B2_and_6_keto_prostaglandin_F1_alpha_in_epidemic_hemorrhagic_fever]_ L2 - http://www.diseaseinfosearch.org/result/3317 DB - PRIME DP - Unbound Medicine ER -