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[A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever].
Zhonghua Nei Ke Za Zhi 1990; 29(3):138-40, 188ZN

Abstract

Plasma concentrations of Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were dynamically measured with radioimmunoassay in 30 patients of epidemic hemorrhagic fever (EHF). It was found that the levels plasma TXB2 significantly increased and 6-keto-PGF1 alpha decreased in EHF patients as compared with those in controls. The more severe the patient's condition, the higher the level of TXB2 and the lower the level of 6-keto-PGF1 alpha. The ratio of TXB2/6-keto-PGF1 alpha was parallel with the severity of the patient's condition. Plasma TXB and TXB2/6-keto-PGF1 alpha ratio increased significantly in the hemorrhagic and shock group, while 6-keto-PGF1 alpha decreased significantly in the shock group. The results showed that there is a distinct imbalance of TXA2-PGI2 mediated through the increase of TXA2 and decrease of PGI2 in EHF. The imbalance of TXA2-PGI2 participates in the pathogenesis and pathophysiology of hemorrhage, shock and renal dysfunction.

Authors+Show Affiliations

Department of Infectious Diseases, First Affiliated Hospital, Harbin Medical University.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

1976492

Citation

Wang, G Q., et al. "[A Study of the Role of Plasma Thromboxane B2 and 6-keto-prostaglandin F1 Alpha in Epidemic Hemorrhagic Fever]." Zhonghua Nei Ke Za Zhi, vol. 29, no. 3, 1990, pp. 138-40, 188.
Wang GQ, Zou ZZ, Yu DP. [A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever]. Zhonghua Nei Ke Za Zhi. 1990;29(3):138-40, 188.
Wang, G. Q., Zou, Z. Z., & Yu, D. P. (1990). [A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever]. Zhonghua Nei Ke Za Zhi, 29(3), pp. 138-40, 188.
Wang GQ, Zou ZZ, Yu DP. [A Study of the Role of Plasma Thromboxane B2 and 6-keto-prostaglandin F1 Alpha in Epidemic Hemorrhagic Fever]. Zhonghua Nei Ke Za Zhi. 1990;29(3):138-40, 188. PubMed PMID: 1976492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A study of the role of plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha in epidemic hemorrhagic fever]. AU - Wang,G Q, AU - Zou,Z Z, AU - Yu,D P, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 138-40, 188 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 29 IS - 3 N2 - Plasma concentrations of Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were dynamically measured with radioimmunoassay in 30 patients of epidemic hemorrhagic fever (EHF). It was found that the levels plasma TXB2 significantly increased and 6-keto-PGF1 alpha decreased in EHF patients as compared with those in controls. The more severe the patient's condition, the higher the level of TXB2 and the lower the level of 6-keto-PGF1 alpha. The ratio of TXB2/6-keto-PGF1 alpha was parallel with the severity of the patient's condition. Plasma TXB and TXB2/6-keto-PGF1 alpha ratio increased significantly in the hemorrhagic and shock group, while 6-keto-PGF1 alpha decreased significantly in the shock group. The results showed that there is a distinct imbalance of TXA2-PGI2 mediated through the increase of TXA2 and decrease of PGI2 in EHF. The imbalance of TXA2-PGI2 participates in the pathogenesis and pathophysiology of hemorrhage, shock and renal dysfunction. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/1976492/[A_study_of_the_role_of_plasma_thromboxane_B2_and_6_keto_prostaglandin_F1_alpha_in_epidemic_hemorrhagic_fever]_ L2 - http://www.diseaseinfosearch.org/result/3317 DB - PRIME DP - Unbound Medicine ER -