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Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats.
Brain Res. 2009 Dec 08; 1301:52-60.BR

Abstract

The present study investigates the effect of chronic curcumin administration on phenytoin-induced cognitive impairment and oxidative stress in rats. Male Wistar rats were administered drugs/vehicle for 21 days. Learning and memory was evaluated using the passive avoidance paradigm and the elevated plus maze. On day 21, serum phenytoin concentrations and whole brain malondialdehyde (MDA) and glutathione (GSH) levels were estimated. Phenytoin (75 mg/kg, i.p.) produced significant deficits in learning/memory as indicated by the significant increase in retention transfer latency in elevated plus maze test and a significant decrease in retention latency in the passive avoidance paradigm. Chronic administration of phenytoin also produced significant elevations in brain MDA and reduction of brain GSH levels. Curcumin (100, 200 and 300 mg/kg, orally), when administered with phenytoin, significantly prevented phenytoin-induced cognitive impairment and oxidative stress in a dose-dependent manner. There were no significant differences in the serum levels of phenytoin in any of the treatment groups. This study demonstrates that curcumin is effective in preventing phenytoin-induced cognitive impairment and oxidative stress in rats without altering the serum phenytoin levels. This suggests the potential of adjuvant curcumin therapy in ameliorating cognitive impairment caused by chronic phenytoin therapy.

Authors+Show Affiliations

Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19765566

Citation

Reeta, K H., et al. "Curcumin Is Protective Against Phenytoin-induced Cognitive Impairment and Oxidative Stress in Rats." Brain Research, vol. 1301, 2009, pp. 52-60.
Reeta KH, Mehla J, Gupta YK. Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats. Brain Res. 2009;1301:52-60.
Reeta, K. H., Mehla, J., & Gupta, Y. K. (2009). Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats. Brain Research, 1301, 52-60. https://doi.org/10.1016/j.brainres.2009.09.027
Reeta KH, Mehla J, Gupta YK. Curcumin Is Protective Against Phenytoin-induced Cognitive Impairment and Oxidative Stress in Rats. Brain Res. 2009 Dec 8;1301:52-60. PubMed PMID: 19765566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats. AU - Reeta,K H, AU - Mehla,Jogender, AU - Gupta,Yogendra Kumar, Y1 - 2009/09/16/ PY - 2009/06/07/received PY - 2009/09/04/revised PY - 2009/09/06/accepted PY - 2009/9/22/entrez PY - 2009/9/22/pubmed PY - 2010/1/6/medline SP - 52 EP - 60 JF - Brain research JO - Brain Res VL - 1301 N2 - The present study investigates the effect of chronic curcumin administration on phenytoin-induced cognitive impairment and oxidative stress in rats. Male Wistar rats were administered drugs/vehicle for 21 days. Learning and memory was evaluated using the passive avoidance paradigm and the elevated plus maze. On day 21, serum phenytoin concentrations and whole brain malondialdehyde (MDA) and glutathione (GSH) levels were estimated. Phenytoin (75 mg/kg, i.p.) produced significant deficits in learning/memory as indicated by the significant increase in retention transfer latency in elevated plus maze test and a significant decrease in retention latency in the passive avoidance paradigm. Chronic administration of phenytoin also produced significant elevations in brain MDA and reduction of brain GSH levels. Curcumin (100, 200 and 300 mg/kg, orally), when administered with phenytoin, significantly prevented phenytoin-induced cognitive impairment and oxidative stress in a dose-dependent manner. There were no significant differences in the serum levels of phenytoin in any of the treatment groups. This study demonstrates that curcumin is effective in preventing phenytoin-induced cognitive impairment and oxidative stress in rats without altering the serum phenytoin levels. This suggests the potential of adjuvant curcumin therapy in ameliorating cognitive impairment caused by chronic phenytoin therapy. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19765566/Curcumin_is_protective_against_phenytoin_induced_cognitive_impairment_and_oxidative_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)01929-5 DB - PRIME DP - Unbound Medicine ER -