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Pancreatic tissue protective nature of D-Pinitol studied in streptozotocin-mediated oxidative stress in experimental diabetic rats.
Eur J Pharmacol. 2009 Nov 10; 622(1-3):65-70.EJ

Abstract

The present study was aimed to investigate the possible pancreatic tissue protective nature of D-Pinitol, a cyclitol present in soybean, against free radical-mediated oxidative stress in streptozotocin-induced diabetic rats by assaying the activity of pancreatic enzymatic antioxidants such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione-S-transferase (GST) and the levels of plasma non-enzymatic antioxidants such as vitamin E, vitamin C, ceruloplasmin and reduced glutathione (GSH). To assess the extent of oxidative stress, the levels of lipid peroxidation (LPO) and hydroperoxides in both plasma and pancreatic tissues were also measured. A significant increase in the levels of both lipid peroxides and hydroperoxides with a concomitant decrease in antioxidant status was observed in the diabetic rats when compared to control rats. Oral administration of D-Pinitol (50 mg/kg b.w./day for 30 days), a major cyclitol present in soybean, ameliorates the free radical-mediated alterations to near normalcy. The pancreatic tissue protective nature of D-Pinitol was further evidenced by histological observations. The results were statistically comparable with glyclazide, a standard hypoglycemic drug. Thus, the results of the present study suggest that D-Pinitol protects the pancreatic tissue from free radical-mediated oxidative stress in addition to its antidiabetic property.

Authors+Show Affiliations

Department of Biochemistry, University of Madras, Guindy campus, Chennai, Tamilnadu, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19765586

Citation

Sivakumar, Selvaraj, and Sorimuthu Pillai Subramanian. "Pancreatic Tissue Protective Nature of D-Pinitol Studied in Streptozotocin-mediated Oxidative Stress in Experimental Diabetic Rats." European Journal of Pharmacology, vol. 622, no. 1-3, 2009, pp. 65-70.
Sivakumar S, Subramanian SP. Pancreatic tissue protective nature of D-Pinitol studied in streptozotocin-mediated oxidative stress in experimental diabetic rats. Eur J Pharmacol. 2009;622(1-3):65-70.
Sivakumar, S., & Subramanian, S. P. (2009). Pancreatic tissue protective nature of D-Pinitol studied in streptozotocin-mediated oxidative stress in experimental diabetic rats. European Journal of Pharmacology, 622(1-3), 65-70. https://doi.org/10.1016/j.ejphar.2009.09.021
Sivakumar S, Subramanian SP. Pancreatic Tissue Protective Nature of D-Pinitol Studied in Streptozotocin-mediated Oxidative Stress in Experimental Diabetic Rats. Eur J Pharmacol. 2009 Nov 10;622(1-3):65-70. PubMed PMID: 19765586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic tissue protective nature of D-Pinitol studied in streptozotocin-mediated oxidative stress in experimental diabetic rats. AU - Sivakumar,Selvaraj, AU - Subramanian,Sorimuthu Pillai, Y1 - 2009/09/16/ PY - 2009/05/28/received PY - 2009/08/19/revised PY - 2009/09/08/accepted PY - 2009/9/22/entrez PY - 2009/9/22/pubmed PY - 2010/2/18/medline SP - 65 EP - 70 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 622 IS - 1-3 N2 - The present study was aimed to investigate the possible pancreatic tissue protective nature of D-Pinitol, a cyclitol present in soybean, against free radical-mediated oxidative stress in streptozotocin-induced diabetic rats by assaying the activity of pancreatic enzymatic antioxidants such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione-S-transferase (GST) and the levels of plasma non-enzymatic antioxidants such as vitamin E, vitamin C, ceruloplasmin and reduced glutathione (GSH). To assess the extent of oxidative stress, the levels of lipid peroxidation (LPO) and hydroperoxides in both plasma and pancreatic tissues were also measured. A significant increase in the levels of both lipid peroxides and hydroperoxides with a concomitant decrease in antioxidant status was observed in the diabetic rats when compared to control rats. Oral administration of D-Pinitol (50 mg/kg b.w./day for 30 days), a major cyclitol present in soybean, ameliorates the free radical-mediated alterations to near normalcy. The pancreatic tissue protective nature of D-Pinitol was further evidenced by histological observations. The results were statistically comparable with glyclazide, a standard hypoglycemic drug. Thus, the results of the present study suggest that D-Pinitol protects the pancreatic tissue from free radical-mediated oxidative stress in addition to its antidiabetic property. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/19765586/Pancreatic_tissue_protective_nature_of_D_Pinitol_studied_in_streptozotocin_mediated_oxidative_stress_in_experimental_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(09)00787-0 DB - PRIME DP - Unbound Medicine ER -