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The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage.
Clin Immunol. 2009 Dec; 133(3):402-10.CI

Abstract

The present study was undertaken to analyze the changes in the proportion of CD4(+)CD25(bright) regulatory T (Treg) cells and the expression of costimulatory molecules, CTLA-4 and CD28, in the peripheral blood and deciduas in the setting of non-pregnancy, normal early pregnancy and miscarriage. In this study, we showed that CD4(+)CD25(bright) T cells significantly increased in the peripheral of normal pregnancy compared to that of non-pregnancy. The proportions of CD4(+)CD25(bright) T cells in both peripheral blood and deciduas were significantly lower in miscarriage than that of normal pregnancy. CD4(+)CD25(bright) T cells were characterized by high-level FoxP3 expression and low-level CD69 expression. An increase in the CD28 mRNA expression was accompanied by a decrease in the CTLA-4 mRNA expression in decidual tissues from human miscarriage. The ratios of CTLA-4(+)/CD28(+) in miscarriage were significantly lower than that of the normal pregnancy both in the peripheral and in deciduas. The ratio of CTLA-4(+)/CD28(+) in CD4(+)CD25(bright) T cells was significantly higher than that of the CD4(+)CD25(dim) T cells both in normal pregnancy and in miscarriage. The decidual T cells in the miscarriage appeared higher in responsiveness and IL-2 and IFN-gamma production in comparison with the decidual T cells in the early pregnancy. These results above suggest that CD4(+)CD25(bright) Treg cells might play a role in the maintenance of pregnancy via up-regulation of CTLA-4 expression. The down-regulation of Treg cells and their functions, and the imbalance of positive and negative regulators of costimulatory signals might lead to an abnormal immune milieu, which confer susceptibility to pregnancy loss.

Authors+Show Affiliations

Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19766059

Citation

Jin, Li-Ping, et al. "The CD4+CD25 Bright Regulatory T Cells and CTLA-4 Expression in Peripheral and Decidual Lymphocytes Are Down-regulated in Human Miscarriage." Clinical Immunology (Orlando, Fla.), vol. 133, no. 3, 2009, pp. 402-10.
Jin LP, Chen QY, Zhang T, et al. The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clin Immunol. 2009;133(3):402-10.
Jin, L. P., Chen, Q. Y., Zhang, T., Guo, P. F., & Li, D. J. (2009). The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clinical Immunology (Orlando, Fla.), 133(3), 402-10. https://doi.org/10.1016/j.clim.2009.08.009
Jin LP, et al. The CD4+CD25 Bright Regulatory T Cells and CTLA-4 Expression in Peripheral and Decidual Lymphocytes Are Down-regulated in Human Miscarriage. Clin Immunol. 2009;133(3):402-10. PubMed PMID: 19766059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. AU - Jin,Li-Ping, AU - Chen,Qiao-Ying, AU - Zhang,Tai, AU - Guo,Pei-Fen, AU - Li,Da-Jin, Y1 - 2009/09/18/ PY - 2009/01/16/received PY - 2009/08/07/revised PY - 2009/08/07/accepted PY - 2009/9/22/entrez PY - 2009/9/22/pubmed PY - 2009/12/23/medline SP - 402 EP - 10 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 133 IS - 3 N2 - The present study was undertaken to analyze the changes in the proportion of CD4(+)CD25(bright) regulatory T (Treg) cells and the expression of costimulatory molecules, CTLA-4 and CD28, in the peripheral blood and deciduas in the setting of non-pregnancy, normal early pregnancy and miscarriage. In this study, we showed that CD4(+)CD25(bright) T cells significantly increased in the peripheral of normal pregnancy compared to that of non-pregnancy. The proportions of CD4(+)CD25(bright) T cells in both peripheral blood and deciduas were significantly lower in miscarriage than that of normal pregnancy. CD4(+)CD25(bright) T cells were characterized by high-level FoxP3 expression and low-level CD69 expression. An increase in the CD28 mRNA expression was accompanied by a decrease in the CTLA-4 mRNA expression in decidual tissues from human miscarriage. The ratios of CTLA-4(+)/CD28(+) in miscarriage were significantly lower than that of the normal pregnancy both in the peripheral and in deciduas. The ratio of CTLA-4(+)/CD28(+) in CD4(+)CD25(bright) T cells was significantly higher than that of the CD4(+)CD25(dim) T cells both in normal pregnancy and in miscarriage. The decidual T cells in the miscarriage appeared higher in responsiveness and IL-2 and IFN-gamma production in comparison with the decidual T cells in the early pregnancy. These results above suggest that CD4(+)CD25(bright) Treg cells might play a role in the maintenance of pregnancy via up-regulation of CTLA-4 expression. The down-regulation of Treg cells and their functions, and the imbalance of positive and negative regulators of costimulatory signals might lead to an abnormal immune milieu, which confer susceptibility to pregnancy loss. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/19766059/The_CD4+CD25_bright_regulatory_T_cells_and_CTLA_4_expression_in_peripheral_and_decidual_lymphocytes_are_down_regulated_in_human_miscarriage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(09)00768-2 DB - PRIME DP - Unbound Medicine ER -