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Biology of lung dendritic cells at the origin of asthma.
Immunity 2009; 31(3):412-24I

Abstract

Dendritic cells (DCs) initiate and maintain adaptive T helper 2 (Th2) cell responses to inhaled allergens in asthma. Various functions like antigen uptake, migration to the draining LNs, and induction of tolerance and adaptive immunity are not equally shared by all subsets of DCs, adding considerable complexity to understanding the immunology of allergic sensitization. Whereas the epithelium was initially considered solely as a physical barrier, it is now seen as a central player in controlling the function of lung DCs through release of Th2 cell-promoting cytokines. Although DCs are sufficient and necessary for induction of Th2 cell responses to many antigens, some allergens might require antigen presentation by basophils. Clinically relevant allergens, as well as environmental and genetic risk factors for allergy and asthma, often interfere directly or indirectly with the innate immune functions of airway epithelial cells, basophils, and DCs. This review summarizes the recent progress on our understanding how DCs control Th2 cell immunity in the lung.

Authors+Show Affiliations

Department of Respiratory Diseases, Laboratory of Immunoregulation and Mucosal Immunology, University Hospital Gent, Gent 9000, Belgium. bart.lambrecht@ugent.beNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19766084

Citation

Lambrecht, Bart N., and Hamida Hammad. "Biology of Lung Dendritic Cells at the Origin of Asthma." Immunity, vol. 31, no. 3, 2009, pp. 412-24.
Lambrecht BN, Hammad H. Biology of lung dendritic cells at the origin of asthma. Immunity. 2009;31(3):412-24.
Lambrecht, B. N., & Hammad, H. (2009). Biology of lung dendritic cells at the origin of asthma. Immunity, 31(3), pp. 412-24. doi:10.1016/j.immuni.2009.08.008.
Lambrecht BN, Hammad H. Biology of Lung Dendritic Cells at the Origin of Asthma. Immunity. 2009 Sep 18;31(3):412-24. PubMed PMID: 19766084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biology of lung dendritic cells at the origin of asthma. AU - Lambrecht,Bart N, AU - Hammad,Hamida, PY - 2009/9/22/entrez PY - 2009/9/22/pubmed PY - 2009/9/30/medline SP - 412 EP - 24 JF - Immunity JO - Immunity VL - 31 IS - 3 N2 - Dendritic cells (DCs) initiate and maintain adaptive T helper 2 (Th2) cell responses to inhaled allergens in asthma. Various functions like antigen uptake, migration to the draining LNs, and induction of tolerance and adaptive immunity are not equally shared by all subsets of DCs, adding considerable complexity to understanding the immunology of allergic sensitization. Whereas the epithelium was initially considered solely as a physical barrier, it is now seen as a central player in controlling the function of lung DCs through release of Th2 cell-promoting cytokines. Although DCs are sufficient and necessary for induction of Th2 cell responses to many antigens, some allergens might require antigen presentation by basophils. Clinically relevant allergens, as well as environmental and genetic risk factors for allergy and asthma, often interfere directly or indirectly with the innate immune functions of airway epithelial cells, basophils, and DCs. This review summarizes the recent progress on our understanding how DCs control Th2 cell immunity in the lung. SN - 1097-4180 UR - https://www.unboundmedicine.com/medline/citation/19766084/Biology_of_lung_dendritic_cells_at_the_origin_of_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7613(09)00366-5 DB - PRIME DP - Unbound Medicine ER -