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Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder.
J Affect Disord. 2010 Jun; 123(1-3):276-82.JA

Abstract

BACKGROUND

Functional abnormalities of the superior temporal gyrus (STG) have been implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies of this region have yielded inconsistent findings.

METHOD

We used MRI to examine the volumes of the STG and its gray matter subregions [planum polare (PP), Heschl gyrus (HG), planum temporale (PT), and lateral STG (rostral and caudal regions)] in 26 patients with established bipolar I disorder (8 males and 18 females, mean age=38.4 years) and 24 age and gender-matched healthy controls (7 males and 17 females, mean age=38.7 years).

RESULTS

Bipolar patients had significantly smaller volumes of the PT and caudal STG compared with controls in the left hemisphere. The STG white matter volume did not differ between the groups. There was no association between the STG volume and number of manic/depressive episodes, family history, or clinical subtype (i.e., psychotic and nonpsychotic), but daily dosage of lithium treatment at the time of scanning was positively correlated with right PP and right rostral STG volumes.

LIMITATIONS

Entire clinical data (e.g., lifetime medication, symptomatology) were not available.

CONCLUSIONS

These findings implicate a role for the STG gray matter, especially its left posterior regions, in the neurobiology of bipolar disorder. Our findings may also support the notion of lithium-induced gray matter expansion.

Authors+Show Affiliations

Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia. tsutomu@med.u-toyama.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19766321

Citation

Takahashi, Tsutomu, et al. "Gray Matter Reduction of the Superior Temporal Gyrus in Patients With Established Bipolar I Disorder." Journal of Affective Disorders, vol. 123, no. 1-3, 2010, pp. 276-82.
Takahashi T, Malhi GS, Wood SJ, et al. Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder. J Affect Disord. 2010;123(1-3):276-82.
Takahashi, T., Malhi, G. S., Wood, S. J., Yücel, M., Walterfang, M., Kawasaki, Y., Suzuki, M., & Pantelis, C. (2010). Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder. Journal of Affective Disorders, 123(1-3), 276-82. https://doi.org/10.1016/j.jad.2009.08.022
Takahashi T, et al. Gray Matter Reduction of the Superior Temporal Gyrus in Patients With Established Bipolar I Disorder. J Affect Disord. 2010;123(1-3):276-82. PubMed PMID: 19766321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder. AU - Takahashi,Tsutomu, AU - Malhi,Gin S, AU - Wood,Stephen J, AU - Yücel,Murat, AU - Walterfang,Mark, AU - Kawasaki,Yasuhiro, AU - Suzuki,Michio, AU - Pantelis,Christos, Y1 - 2009/09/18/ PY - 2009/08/07/received PY - 2009/08/29/revised PY - 2009/08/29/accepted PY - 2009/9/22/entrez PY - 2009/9/22/pubmed PY - 2010/7/27/medline SP - 276 EP - 82 JF - Journal of affective disorders JO - J Affect Disord VL - 123 IS - 1-3 N2 - BACKGROUND: Functional abnormalities of the superior temporal gyrus (STG) have been implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies of this region have yielded inconsistent findings. METHOD: We used MRI to examine the volumes of the STG and its gray matter subregions [planum polare (PP), Heschl gyrus (HG), planum temporale (PT), and lateral STG (rostral and caudal regions)] in 26 patients with established bipolar I disorder (8 males and 18 females, mean age=38.4 years) and 24 age and gender-matched healthy controls (7 males and 17 females, mean age=38.7 years). RESULTS: Bipolar patients had significantly smaller volumes of the PT and caudal STG compared with controls in the left hemisphere. The STG white matter volume did not differ between the groups. There was no association between the STG volume and number of manic/depressive episodes, family history, or clinical subtype (i.e., psychotic and nonpsychotic), but daily dosage of lithium treatment at the time of scanning was positively correlated with right PP and right rostral STG volumes. LIMITATIONS: Entire clinical data (e.g., lifetime medication, symptomatology) were not available. CONCLUSIONS: These findings implicate a role for the STG gray matter, especially its left posterior regions, in the neurobiology of bipolar disorder. Our findings may also support the notion of lithium-induced gray matter expansion. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/19766321/Gray_matter_reduction_of_the_superior_temporal_gyrus_in_patients_with_established_bipolar_I_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(09)00405-4 DB - PRIME DP - Unbound Medicine ER -