Tags

Type your tag names separated by a space and hit enter

Loss of nocturnal blood pressure fall in various extrapyramidal syndromes.
Mov Disord. 2009 Oct 30; 24(14):2136-42.MD

Abstract

Cardiovascular autonomic dysfunction has frequently been reported in some patients with extrapyramidal syndromes, especially multiple system atrophy (MSA) but also Parkinson's disease (PD). However, there are only few reports on the prevalence of cardiovascular autonomic dysfunction progressive in supranuclear palsy (PSP). Moreover, the relation of detailed cardiovascular testing and easy to assess 24-hour ambulatory blood pressure (BP) is not known. Our study evaluates 24-hour ambulatory BP monitoring in patients with PD, PSP, MSA, and corresponding controls (Con) and relates the findings to the results of comprehensive cardiovascular autonomic testing. Twenty-three patients with PD, 25 patients with PSP, 25 patients with MSA, and 26 corresponding controls were studied by 24-hour ambulatory BP monitoring (ABPM) in comparison to cardiovascular autonomic testing. Patients with PD, PSP, and MSA presented frequently with a pathological nocturnal BP regulation (no decrease or even an increase of nocturnal BP) in comparison to the control group (PD 48%, PSP 40%, MSA 68% vs. Con 8%). In MSA and PD patients, the frequent pathological BP increase during night was closely correlated to orthostatic hypotension. Since loss of nocturnal BP fall is frequent in patients with extrapyramidal syndromes, even if they are free of subjective autonomic dysfunction, we recommend 24-hour ABPM as an easy to perform screening test, especially if detailed autonomic testing is not available. Pathological loss of nocturnal BP fall may account for increased cardiovascular mortality in extrapyramidal syndromes.

Links

Aggregator Full Text

Authors+Show Affiliations

Schmidt C
Autonomic and Neuroendocrinological Laboratory, University Clinic Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
Berg D
No affiliation info available
Herting
No affiliation info available
Prieur S
No affiliation info available
Junghanns S
No affiliation info available
Schweitzer K
No affiliation info available
Globas C
No affiliation info available
Schöls L
No affiliation info available
Reichmann H
No affiliation info available
Ziemssen T
No affiliation info available

MeSH

AgedAutonomic Nervous SystemAutonomic Nervous System DiseasesBasal Ganglia DiseasesBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmCross-Sectional StudiesFemaleHeart RateHumansHypertensionMaleMiddle AgedMultiple System AtrophyParkinson DiseaseSupranuclear Palsy, ProgressiveTilt-Table Test

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19768815

Clinical Trial Links

Effects of Feet Mechanical Stimulation on Cardiovascular Autonomic Profile and Inflammation in Parkinson's Disease

Citation

Schmidt, Claudia, et al. "Loss of Nocturnal Blood Pressure Fall in Various Extrapyramidal Syndromes." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 24, no. 14, 2009, pp. 2136-42.
Schmidt C, Berg D, Herting, et al. Loss of nocturnal blood pressure fall in various extrapyramidal syndromes. Mov Disord. 2009;24(14):2136-42.
Schmidt, C., Berg, D., Prieur, S., Junghanns, S., Schweitzer, K., Globas, C., Schöls, L., Reichmann, H., & Ziemssen, T. (2009). Loss of nocturnal blood pressure fall in various extrapyramidal syndromes. Movement Disorders : Official Journal of the Movement Disorder Society, 24(14), 2136-42. https://doi.org/10.1002/mds.22767
Schmidt C, et al. Loss of Nocturnal Blood Pressure Fall in Various Extrapyramidal Syndromes. Mov Disord. 2009 Oct 30;24(14):2136-42. PubMed PMID: 19768815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Loss of nocturnal blood pressure fall in various extrapyramidal syndromes. AU - Schmidt,Claudia, AU - Berg,Daniela, AU - ,, AU - Prieur,Silke, AU - Junghanns,Susann, AU - Schweitzer,Katherine, AU - Globas,Christoph, AU - Schöls,Ludger, AU - Reichmann,Heinz, AU - Ziemssen,Tjalf, PY - 2009/9/22/entrez PY - 2009/9/22/pubmed PY - 2010/1/13/medline SP - 2136 EP - 42 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 24 IS - 14 N2 - Cardiovascular autonomic dysfunction has frequently been reported in some patients with extrapyramidal syndromes, especially multiple system atrophy (MSA) but also Parkinson's disease (PD). However, there are only few reports on the prevalence of cardiovascular autonomic dysfunction progressive in supranuclear palsy (PSP). Moreover, the relation of detailed cardiovascular testing and easy to assess 24-hour ambulatory blood pressure (BP) is not known. Our study evaluates 24-hour ambulatory BP monitoring in patients with PD, PSP, MSA, and corresponding controls (Con) and relates the findings to the results of comprehensive cardiovascular autonomic testing. Twenty-three patients with PD, 25 patients with PSP, 25 patients with MSA, and 26 corresponding controls were studied by 24-hour ambulatory BP monitoring (ABPM) in comparison to cardiovascular autonomic testing. Patients with PD, PSP, and MSA presented frequently with a pathological nocturnal BP regulation (no decrease or even an increase of nocturnal BP) in comparison to the control group (PD 48%, PSP 40%, MSA 68% vs. Con 8%). In MSA and PD patients, the frequent pathological BP increase during night was closely correlated to orthostatic hypotension. Since loss of nocturnal BP fall is frequent in patients with extrapyramidal syndromes, even if they are free of subjective autonomic dysfunction, we recommend 24-hour ABPM as an easy to perform screening test, especially if detailed autonomic testing is not available. Pathological loss of nocturnal BP fall may account for increased cardiovascular mortality in extrapyramidal syndromes. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/19768815/Loss_of_nocturnal_blood_pressure_fall_in_various_extrapyramidal_syndromes_ L2 - https://doi.org/10.1002/mds.22767 DB - PRIME DP - Unbound Medicine ER -