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Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function.
Antioxid Redox Signal. 2010 May 01; 12(9):1135-46.AR

Abstract

Hydrogen sulfide (H(2)S) has long been associated with the gastrointestinal tract, especially the bacteria-derived H(2)S present in flatus. Along with evidence from other organ systems, the finding that gastrointestinal tissues are capable of endogenous production of H(2)S has led to the hypothesis that H(2)S is an endogenous gaseous signaling molecule. In this review, the criteria of gasotransmitters are reexamined, and evidence from the literature regarding H(2)S as a gaseous signaling molecule is discussed. H(2)S is produced enzymatically by gastrointestinal tissues, but evidence is lacking on whether H(2)S production is regulated. H(2)S causes well-defined physiologic effects in gastrointestinal tissues, but evidence for a receptor for H(2)S is lacking. H(2)S is inactivated through enzymatic oxidation, but evidence is lacking on whether manipulating H(2)S oxidation alters endogenous cell signaling. Remaining questions regarding the role of H(2)S as a gaseous signaling molecule in the gastrointestinal tract suggest that H(2)S currently remains a molecule in search of a physiologic function.

Authors+Show Affiliations

Enteric NeuroScience Program, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. gijoe@mayo.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19769466

Citation

Linden, David R., et al. "Endogenous Production of H2S in the Gastrointestinal Tract: Still in Search of a Physiologic Function." Antioxidants & Redox Signaling, vol. 12, no. 9, 2010, pp. 1135-46.
Linden DR, Levitt MD, Farrugia G, et al. Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. Antioxid Redox Signal. 2010;12(9):1135-46.
Linden, D. R., Levitt, M. D., Farrugia, G., & Szurszewski, J. H. (2010). Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. Antioxidants & Redox Signaling, 12(9), 1135-46. https://doi.org/10.1089/ars.2009.2885
Linden DR, et al. Endogenous Production of H2S in the Gastrointestinal Tract: Still in Search of a Physiologic Function. Antioxid Redox Signal. 2010 May 1;12(9):1135-46. PubMed PMID: 19769466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. AU - Linden,David R, AU - Levitt,Michael D, AU - Farrugia,Gianrico, AU - Szurszewski,Joseph H, PY - 2009/9/23/entrez PY - 2009/9/23/pubmed PY - 2010/7/16/medline SP - 1135 EP - 46 JF - Antioxidants & redox signaling JO - Antioxid. Redox Signal. VL - 12 IS - 9 N2 - Hydrogen sulfide (H(2)S) has long been associated with the gastrointestinal tract, especially the bacteria-derived H(2)S present in flatus. Along with evidence from other organ systems, the finding that gastrointestinal tissues are capable of endogenous production of H(2)S has led to the hypothesis that H(2)S is an endogenous gaseous signaling molecule. In this review, the criteria of gasotransmitters are reexamined, and evidence from the literature regarding H(2)S as a gaseous signaling molecule is discussed. H(2)S is produced enzymatically by gastrointestinal tissues, but evidence is lacking on whether H(2)S production is regulated. H(2)S causes well-defined physiologic effects in gastrointestinal tissues, but evidence for a receptor for H(2)S is lacking. H(2)S is inactivated through enzymatic oxidation, but evidence is lacking on whether manipulating H(2)S oxidation alters endogenous cell signaling. Remaining questions regarding the role of H(2)S as a gaseous signaling molecule in the gastrointestinal tract suggest that H(2)S currently remains a molecule in search of a physiologic function. SN - 1557-7716 UR - https://www.unboundmedicine.com/medline/citation/19769466/Endogenous_production_of_H2S_in_the_gastrointestinal_tract:_still_in_search_of_a_physiologic_function_ L2 - https://www.liebertpub.com/doi/full/10.1089/ars.2009.2885?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -