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Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: the generation R study.
Clin Endocrinol (Oxf) 2010; 72(5):633-40CE

Abstract

OBJECTIVE

Early weight gain is associated with an increased risk of obesity. It is not known whether rapid weight gain in foetal life and infancy is also associated with increased abdominal adiposity. We examined the associations of foetal and postnatal growth characteristics with abdominal fat mass at the age of 2 years.

DESIGN

This study was performed in 481 children participating in a prospective cohort study from early foetal life onward.

MEASUREMENTS

Foetal and postnatal growth characteristics in second and third trimester, at birth and at the age of 2 years were related to abdominal fat mass (subcutaneous distance and area, preperitoneal distance and area) measured by ultrasound at the age of 2 years.

RESULTS

Foetal and birth weight were not associated with abdominal subcutaneous fat mass. Estimated foetal weight in second trimester of pregnancy was inversely associated with preperitoneal fat area [-3.73% (95% confidence interval -7.23, -0.10)] per standard deviation score increase in weight. Weight gain from birth to the age of 2 years was positively associated with preperitoneal fat mass measures. These associations remained significant after adjustment for age, sex, breastfeeding and body mass index. Positive associations were found between catch-up growth in weight and abdominal fat mass measures.

CONCLUSIONS

Our results suggest that rapid growth rates during foetal life and infancy are associated with increased abdominal subcutaneous and preperitoneal fat mass in healthy children. Further studies need to explore whether these associations persist in later life and are related to metabolic syndrome outcomes.

Authors+Show Affiliations

The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19769622

Citation

Durmuş, Büşra, et al. "Growth in Foetal Life and Infancy Is Associated With Abdominal Adiposity at the Age of 2 Years: the Generation R Study." Clinical Endocrinology, vol. 72, no. 5, 2010, pp. 633-40.
Durmuş B, Mook-Kanamori DO, Holzhauer S, et al. Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: the generation R study. Clin Endocrinol (Oxf). 2010;72(5):633-40.
Durmuş, B., Mook-Kanamori, D. O., Holzhauer, S., Hofman, A., van der Beek, E. M., Boehm, G., ... Jaddoe, V. W. (2010). Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: the generation R study. Clinical Endocrinology, 72(5), pp. 633-40. doi:10.1111/j.1365-2265.2009.03708.x.
Durmuş B, et al. Growth in Foetal Life and Infancy Is Associated With Abdominal Adiposity at the Age of 2 Years: the Generation R Study. Clin Endocrinol (Oxf). 2010;72(5):633-40. PubMed PMID: 19769622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: the generation R study. AU - Durmuş,Büşra, AU - Mook-Kanamori,Dennis O, AU - Holzhauer,Susanne, AU - Hofman,Albert, AU - van der Beek,Eline M, AU - Boehm,Güenther, AU - Steegers,Eric A P, AU - Jaddoe,Vincent W V, Y1 - 2009/09/21/ PY - 2009/9/23/entrez PY - 2009/9/23/pubmed PY - 2010/8/11/medline SP - 633 EP - 40 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 72 IS - 5 N2 - OBJECTIVE: Early weight gain is associated with an increased risk of obesity. It is not known whether rapid weight gain in foetal life and infancy is also associated with increased abdominal adiposity. We examined the associations of foetal and postnatal growth characteristics with abdominal fat mass at the age of 2 years. DESIGN: This study was performed in 481 children participating in a prospective cohort study from early foetal life onward. MEASUREMENTS: Foetal and postnatal growth characteristics in second and third trimester, at birth and at the age of 2 years were related to abdominal fat mass (subcutaneous distance and area, preperitoneal distance and area) measured by ultrasound at the age of 2 years. RESULTS: Foetal and birth weight were not associated with abdominal subcutaneous fat mass. Estimated foetal weight in second trimester of pregnancy was inversely associated with preperitoneal fat area [-3.73% (95% confidence interval -7.23, -0.10)] per standard deviation score increase in weight. Weight gain from birth to the age of 2 years was positively associated with preperitoneal fat mass measures. These associations remained significant after adjustment for age, sex, breastfeeding and body mass index. Positive associations were found between catch-up growth in weight and abdominal fat mass measures. CONCLUSIONS: Our results suggest that rapid growth rates during foetal life and infancy are associated with increased abdominal subcutaneous and preperitoneal fat mass in healthy children. Further studies need to explore whether these associations persist in later life and are related to metabolic syndrome outcomes. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/19769622/Growth_in_foetal_life_and_infancy_is_associated_with_abdominal_adiposity_at_the_age_of_2_years:_the_generation_R_study_ L2 - https://doi.org/10.1111/j.1365-2265.2009.03708.x DB - PRIME DP - Unbound Medicine ER -