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Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.
BMC Med Genet 2009; 10:94BM

Abstract

BACKGROUND

We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the uncoupling protein 3 (UCP3) gene with obesity and diabetes related traits in subjects with impaired glucose tolerance participating in Finnish Diabetes Prevention Study. Altogether 507 overweight individuals (body mass index: 31.2 +/- 4.5 kg/m2, age: 55 +/- 7 years) for whom DNA was available were randomized to either an intensified diet and physical activity group or to a conventional care control group.

METHODS

We analysed the data from the baseline and annual follow-up visits from years 1, 2 and 3. Measurements of anthropometry, plasma glucose and serum insulin in oral glucose tolerance test, serum total cholesterol, HDL-cholesterol and triglycerides were included. The median follow-up time for type 2 diabetes incidence was 7 years. Genetic variants were screened by restriction fragment length polymorphism or Illumina method.

RESULTS

UCP3 gene variant rs3781907 was associated with increased serum total and LDL-cholesterol levels, at baseline and during the follow-up period. The same variant was associated with a higher risk of type 2 diabetes. Variants rs1726745, rs11235972 and rs1800849 in the UCP3 gene associated with serum total and LDL-cholesterol at baseline. Haploblock including variants rs659366, rs653529, rs15763, and rs1726745 was associated with measures of abdominal obesity at baseline and in the longitudinal analysis. The haplotype comprising alleles rs659366-G, rs653529-A, rs15763-G and rs1726745-A was associated with higher waist-to-hip ratio, and haplotype comprising alleles rs3781907-G, rs11235972-A, and rs1800849-T was associated with increased serum total and LDL-cholesterol concentrations.

CONCLUSION

Genetic variation in the UCP2-UCP3 gene cluster may act as a modifier increasing serum lipid levels and indices of abdominal obesity, and may thereby also contribute to the metabolic aberrations observed in obesity and type 2 diabetes.

Authors+Show Affiliations

University of Kuopio, Department of Clinical Nutrition and Food and Health Research Center, Kuopio, Finland. titta.salopuro@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19769793

Citation

Salopuro, Titta, et al. "Variation in the UCP2 and UCP3 Genes Associates With Abdominal Obesity and Serum Lipids: the Finnish Diabetes Prevention Study." BMC Medical Genetics, vol. 10, 2009, p. 94.
Salopuro T, Pulkkinen L, Lindström J, et al. Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study. BMC Med Genet. 2009;10:94.
Salopuro, T., Pulkkinen, L., Lindström, J., Kolehmainen, M., Tolppanen, A. M., Eriksson, J. G., ... Uusitupa, M. (2009). Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study. BMC Medical Genetics, 10, p. 94. doi:10.1186/1471-2350-10-94.
Salopuro T, et al. Variation in the UCP2 and UCP3 Genes Associates With Abdominal Obesity and Serum Lipids: the Finnish Diabetes Prevention Study. BMC Med Genet. 2009 Sep 21;10:94. PubMed PMID: 19769793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study. AU - Salopuro,Titta, AU - Pulkkinen,Leena, AU - Lindström,Jaana, AU - Kolehmainen,Marjukka, AU - Tolppanen,Anna-Maija, AU - Eriksson,Johan G, AU - Valle,Timo T, AU - Aunola,Sirkka, AU - Ilanne-Parikka,Pirjo, AU - Keinänen-Kiukaanniemi,Sirkka, AU - Tuomilehto,Jaakko, AU - Laakso,Markku, AU - Uusitupa,Matti, Y1 - 2009/09/21/ PY - 2009/03/25/received PY - 2009/09/21/accepted PY - 2009/9/23/entrez PY - 2009/9/23/pubmed PY - 2009/10/2/medline SP - 94 EP - 94 JF - BMC medical genetics JO - BMC Med. Genet. VL - 10 N2 - BACKGROUND: We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the uncoupling protein 3 (UCP3) gene with obesity and diabetes related traits in subjects with impaired glucose tolerance participating in Finnish Diabetes Prevention Study. Altogether 507 overweight individuals (body mass index: 31.2 +/- 4.5 kg/m2, age: 55 +/- 7 years) for whom DNA was available were randomized to either an intensified diet and physical activity group or to a conventional care control group. METHODS: We analysed the data from the baseline and annual follow-up visits from years 1, 2 and 3. Measurements of anthropometry, plasma glucose and serum insulin in oral glucose tolerance test, serum total cholesterol, HDL-cholesterol and triglycerides were included. The median follow-up time for type 2 diabetes incidence was 7 years. Genetic variants were screened by restriction fragment length polymorphism or Illumina method. RESULTS: UCP3 gene variant rs3781907 was associated with increased serum total and LDL-cholesterol levels, at baseline and during the follow-up period. The same variant was associated with a higher risk of type 2 diabetes. Variants rs1726745, rs11235972 and rs1800849 in the UCP3 gene associated with serum total and LDL-cholesterol at baseline. Haploblock including variants rs659366, rs653529, rs15763, and rs1726745 was associated with measures of abdominal obesity at baseline and in the longitudinal analysis. The haplotype comprising alleles rs659366-G, rs653529-A, rs15763-G and rs1726745-A was associated with higher waist-to-hip ratio, and haplotype comprising alleles rs3781907-G, rs11235972-A, and rs1800849-T was associated with increased serum total and LDL-cholesterol concentrations. CONCLUSION: Genetic variation in the UCP2-UCP3 gene cluster may act as a modifier increasing serum lipid levels and indices of abdominal obesity, and may thereby also contribute to the metabolic aberrations observed in obesity and type 2 diabetes. SN - 1471-2350 UR - https://www.unboundmedicine.com/medline/citation/19769793/Variation_in_the_UCP2_and_UCP3_genes_associates_with_abdominal_obesity_and_serum_lipids:_the_Finnish_Diabetes_Prevention_Study_ L2 - https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-10-94 DB - PRIME DP - Unbound Medicine ER -