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Structural and functional brain correlates of subclinical psychotic symptoms in 11-13 year old schoolchildren.
Neuroimage. 2010 Jan 15; 49(2):1875-85.N

Abstract

Studying children experiencing psychotic symptoms provides a unique opportunity to examine the vulnerability to psychosis within the context of development. Using neuroimaging techniques this study investigated cognitive control functions, brain volumetrics and white matter integrity in an at-risk cohort of children. Between-subjects assessment of brain function and structure among 11 school-going, non-treatment seeking children aged 11-13 who were at symptomatic risk for psychosis (AR) and 14 healthy control children aged 11-12 without subclinical psychotic symptoms (CON). MRI assessments included functional measures of response inhibition and error-related processes, whole brain voxel-based morphometry (VBM) of gray matter (GM) and diffusion tensor imaging (DTI) utilizing fractional anisotropy to probe white matter (WM) integrity. fMRI results showed reduced activity in the AR group within right frontal and bilateral temporal cortex for response inhibition and reduced activity within the anterior cingulate, insula and middle frontal gyrus for error-related processing (p<.05, corrected). VBM analysis revealed GM increases in the AR group within middle and superior temporal gyri, angular gyrus, orbitofrontal gyrus and GM decrease within the inferior temporal gyrus (p<.05, corrected). DTI analysis identified WM decreases in the AR group along the inferior fronto-occipital fasciculus, cingulum and inferior longitudinal fasciculus (p<.05, corrected). This multimodal investigation revealed aberrant prefrontal-temporal dysfunction in addition to cingulate and insular dysfunctions which provide potential early neurocognitive risk markers related to the susceptibility for developing psychosis and subsequently the neurodevelopmental trajectory leading to schizophrenia.

Authors+Show Affiliations

School of Psychology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland. jacobsos@tcd.ieNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19770054

Citation

Jacobson, Sarah, et al. "Structural and Functional Brain Correlates of Subclinical Psychotic Symptoms in 11-13 Year Old Schoolchildren." NeuroImage, vol. 49, no. 2, 2010, pp. 1875-85.
Jacobson S, Kelleher I, Harley M, et al. Structural and functional brain correlates of subclinical psychotic symptoms in 11-13 year old schoolchildren. Neuroimage. 2010;49(2):1875-85.
Jacobson, S., Kelleher, I., Harley, M., Murtagh, A., Clarke, M., Blanchard, M., Connolly, C., O'Hanlon, E., Garavan, H., & Cannon, M. (2010). Structural and functional brain correlates of subclinical psychotic symptoms in 11-13 year old schoolchildren. NeuroImage, 49(2), 1875-85. https://doi.org/10.1016/j.neuroimage.2009.09.015
Jacobson S, et al. Structural and Functional Brain Correlates of Subclinical Psychotic Symptoms in 11-13 Year Old Schoolchildren. Neuroimage. 2010 Jan 15;49(2):1875-85. PubMed PMID: 19770054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural and functional brain correlates of subclinical psychotic symptoms in 11-13 year old schoolchildren. AU - Jacobson,Sarah, AU - Kelleher,Ian, AU - Harley,Michelle, AU - Murtagh,Aileen, AU - Clarke,Mary, AU - Blanchard,Mathieu, AU - Connolly,Colm, AU - O'Hanlon,Erik, AU - Garavan,Hugh, AU - Cannon,Mary, Y1 - 2009/09/18/ PY - 2009/04/22/received PY - 2009/08/07/revised PY - 2009/09/11/accepted PY - 2009/9/23/entrez PY - 2009/9/23/pubmed PY - 2010/2/13/medline SP - 1875 EP - 85 JF - NeuroImage JO - Neuroimage VL - 49 IS - 2 N2 - Studying children experiencing psychotic symptoms provides a unique opportunity to examine the vulnerability to psychosis within the context of development. Using neuroimaging techniques this study investigated cognitive control functions, brain volumetrics and white matter integrity in an at-risk cohort of children. Between-subjects assessment of brain function and structure among 11 school-going, non-treatment seeking children aged 11-13 who were at symptomatic risk for psychosis (AR) and 14 healthy control children aged 11-12 without subclinical psychotic symptoms (CON). MRI assessments included functional measures of response inhibition and error-related processes, whole brain voxel-based morphometry (VBM) of gray matter (GM) and diffusion tensor imaging (DTI) utilizing fractional anisotropy to probe white matter (WM) integrity. fMRI results showed reduced activity in the AR group within right frontal and bilateral temporal cortex for response inhibition and reduced activity within the anterior cingulate, insula and middle frontal gyrus for error-related processing (p<.05, corrected). VBM analysis revealed GM increases in the AR group within middle and superior temporal gyri, angular gyrus, orbitofrontal gyrus and GM decrease within the inferior temporal gyrus (p<.05, corrected). DTI analysis identified WM decreases in the AR group along the inferior fronto-occipital fasciculus, cingulum and inferior longitudinal fasciculus (p<.05, corrected). This multimodal investigation revealed aberrant prefrontal-temporal dysfunction in addition to cingulate and insular dysfunctions which provide potential early neurocognitive risk markers related to the susceptibility for developing psychosis and subsequently the neurodevelopmental trajectory leading to schizophrenia. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/19770054/Structural_and_functional_brain_correlates_of_subclinical_psychotic_symptoms_in_11_13_year_old_schoolchildren_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(09)00994-X DB - PRIME DP - Unbound Medicine ER -