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Grapes, wines, resveratrol, and heart health.

Abstract

Epidemiological and experimental studies have revealed that a mild to moderate drinking of wine, particularly red wine, attenuates the cardiovascular, cerebrovascular, and peripheral vascular risk. However, the experimental basis for such health benefits is not fully understood. The cardioprotective effect of wine has been attributed to both components of wine: the alcoholic portion and, more importantly, the alcohol-free portion containing antioxidants. Wines are manufactured from grapes, which also contain a large variety of antioxidants, including resveratrol, catechin, epicatechin, and proanthocyanidins. Resveratrol is mainly found in the grape skin, whereas proanthocyanidins are found only in the seeds. Recent studies have demonstrated that resveratrol and proanthocyanidin are the major compounds present in grapes and wines responsible for cardioprotection. The purpose of this review is to provide evidence that grapes, wines, and resveratrol are equally important in reducing the risk of morbidity and mortality due to cardiovascular complications. Both wines and grapes can attenuate cardiac diseases such as atherosclerosis and ischemic heart disease. Recently, wine was also found to increase life span by inducing longevity genes. It appears that resveratrol and proanthocyanidins, especially resveratrol, present in grapes and wines play a crucial role in cardioprotective abilities of grapes and wines.

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  • Authors+Show Affiliations

    ,

    Institute of Human Anatomy, University of Milan, Milan, Italy.

    Source

    MeSH

    Cardiotonic Agents
    Heart Diseases
    Humans
    Longevity
    Resveratrol
    Stilbenes
    Vitis
    Wine

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    19770673

    Citation

    Bertelli, Alberto A A., and Dipak K. Das. "Grapes, Wines, Resveratrol, and Heart Health." Journal of Cardiovascular Pharmacology, vol. 54, no. 6, 2009, pp. 468-76.
    Bertelli AA, Das DK. Grapes, wines, resveratrol, and heart health. J Cardiovasc Pharmacol. 2009;54(6):468-76.
    Bertelli, A. A., & Das, D. K. (2009). Grapes, wines, resveratrol, and heart health. Journal of Cardiovascular Pharmacology, 54(6), pp. 468-76. doi:10.1097/FJC.0b013e3181bfaff3.
    Bertelli AA, Das DK. Grapes, Wines, Resveratrol, and Heart Health. J Cardiovasc Pharmacol. 2009;54(6):468-76. PubMed PMID: 19770673.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Grapes, wines, resveratrol, and heart health. AU - Bertelli,Alberto A A, AU - Das,Dipak K, PY - 2009/9/23/entrez PY - 2009/9/23/pubmed PY - 2010/4/27/medline SP - 468 EP - 76 JF - Journal of cardiovascular pharmacology JO - J. Cardiovasc. Pharmacol. VL - 54 IS - 6 N2 - Epidemiological and experimental studies have revealed that a mild to moderate drinking of wine, particularly red wine, attenuates the cardiovascular, cerebrovascular, and peripheral vascular risk. However, the experimental basis for such health benefits is not fully understood. The cardioprotective effect of wine has been attributed to both components of wine: the alcoholic portion and, more importantly, the alcohol-free portion containing antioxidants. Wines are manufactured from grapes, which also contain a large variety of antioxidants, including resveratrol, catechin, epicatechin, and proanthocyanidins. Resveratrol is mainly found in the grape skin, whereas proanthocyanidins are found only in the seeds. Recent studies have demonstrated that resveratrol and proanthocyanidin are the major compounds present in grapes and wines responsible for cardioprotection. The purpose of this review is to provide evidence that grapes, wines, and resveratrol are equally important in reducing the risk of morbidity and mortality due to cardiovascular complications. Both wines and grapes can attenuate cardiac diseases such as atherosclerosis and ischemic heart disease. Recently, wine was also found to increase life span by inducing longevity genes. It appears that resveratrol and proanthocyanidins, especially resveratrol, present in grapes and wines play a crucial role in cardioprotective abilities of grapes and wines. SN - 1533-4023 UR - https://www.unboundmedicine.com/medline/citation/19770673/abstract/Grapes_Wines_Resveratrol_and_Heart_Health_ L2 - http://Insights.ovid.com/pubmed?pmid=19770673 DB - PRIME DP - Unbound Medicine ER -