Tags

Type your tag names separated by a space and hit enter

High sensitive serum C-reactive protein and its relationship with other cardiovascular risk factors in normoinsulinemic polycystic ovary patients without metabolic syndrome.
Arch Gynecol Obstet. 2010 Jun; 281(6):1009-14.AG

Abstract

PURPOSE

The aims of the study were to investigate high sensitive serum C-reactive protein (HS-CRP) levels in normoinsulinemic polycystic ovary syndrome (PCOS) patients without metabolic syndrome and whether there was any relationship between HS-CRP and other cardiovascular risk factors such as obesity and serum lipids.

METHODS

A total of 52 normoinsulinemic PCOS women without metabolic syndrome and 48 normoandrogenic ovulatory women were enrolled in the study. Standard clinical examinations, and ultrasonographic and endocrine screening including FSH, LH, total testosterone, free testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC) and triglyceride (TG) were measured. Normal insulin sensitivity was defined on the basis of fasting serum glucose and insulin levels, serum insulin response to an oral glucose tolerance test and homeostatic model of insulin resistance. HS-CRP was assessed spectrophotometrically.

RESULTS

PCOS patients had increased HS-CRP compared to the control group (P < 0.0001). HS-CRP was positively correlated with body mass index (BMI) (r = 0.44, P < 0.0001), waist-to-hip ratio (WHR) (r = 0.66, P < 0.0001), LDL (r = 0.62, P < 0.0001), TC (r = 0.56, P < 0.0001) and TG (r = 0.38, P < 0.0001), and negatively correlated with HDL (r = -0.45, P < 0.0001). There was also a strong association between HS-CRP and PCOS status (r = 0.69, P < 0.0001) in the study. Multivariate regression analysis demonstrated that BMI, WHR, LDL, HDL and PCOS status were also the independent variables that influenced HS-CRP in the overall group.

CONCLUSION

Elevated HS-CRP was associated with cardiovascular risk factors in normoinsulinemic PCOS without metabolic syndrome. These patients need more intensive screening or treatment for this disease.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Harran University Faculty of Medicine, Yenisehir, 63050, Sanliurfa, Turkey. fverit@gmail.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19771438

Citation

Verit, Fatma Ferda. "High Sensitive Serum C-reactive Protein and Its Relationship With Other Cardiovascular Risk Factors in Normoinsulinemic Polycystic Ovary Patients Without Metabolic Syndrome." Archives of Gynecology and Obstetrics, vol. 281, no. 6, 2010, pp. 1009-14.
Verit FF. High sensitive serum C-reactive protein and its relationship with other cardiovascular risk factors in normoinsulinemic polycystic ovary patients without metabolic syndrome. Arch Gynecol Obstet. 2010;281(6):1009-14.
Verit, F. F. (2010). High sensitive serum C-reactive protein and its relationship with other cardiovascular risk factors in normoinsulinemic polycystic ovary patients without metabolic syndrome. Archives of Gynecology and Obstetrics, 281(6), 1009-14. https://doi.org/10.1007/s00404-009-1226-6
Verit FF. High Sensitive Serum C-reactive Protein and Its Relationship With Other Cardiovascular Risk Factors in Normoinsulinemic Polycystic Ovary Patients Without Metabolic Syndrome. Arch Gynecol Obstet. 2010;281(6):1009-14. PubMed PMID: 19771438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High sensitive serum C-reactive protein and its relationship with other cardiovascular risk factors in normoinsulinemic polycystic ovary patients without metabolic syndrome. A1 - Verit,Fatma Ferda, Y1 - 2009/09/22/ PY - 2009/07/15/received PY - 2009/09/08/accepted PY - 2009/9/23/entrez PY - 2009/9/23/pubmed PY - 2010/8/6/medline SP - 1009 EP - 14 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 281 IS - 6 N2 - PURPOSE: The aims of the study were to investigate high sensitive serum C-reactive protein (HS-CRP) levels in normoinsulinemic polycystic ovary syndrome (PCOS) patients without metabolic syndrome and whether there was any relationship between HS-CRP and other cardiovascular risk factors such as obesity and serum lipids. METHODS: A total of 52 normoinsulinemic PCOS women without metabolic syndrome and 48 normoandrogenic ovulatory women were enrolled in the study. Standard clinical examinations, and ultrasonographic and endocrine screening including FSH, LH, total testosterone, free testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulfate, low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC) and triglyceride (TG) were measured. Normal insulin sensitivity was defined on the basis of fasting serum glucose and insulin levels, serum insulin response to an oral glucose tolerance test and homeostatic model of insulin resistance. HS-CRP was assessed spectrophotometrically. RESULTS: PCOS patients had increased HS-CRP compared to the control group (P < 0.0001). HS-CRP was positively correlated with body mass index (BMI) (r = 0.44, P < 0.0001), waist-to-hip ratio (WHR) (r = 0.66, P < 0.0001), LDL (r = 0.62, P < 0.0001), TC (r = 0.56, P < 0.0001) and TG (r = 0.38, P < 0.0001), and negatively correlated with HDL (r = -0.45, P < 0.0001). There was also a strong association between HS-CRP and PCOS status (r = 0.69, P < 0.0001) in the study. Multivariate regression analysis demonstrated that BMI, WHR, LDL, HDL and PCOS status were also the independent variables that influenced HS-CRP in the overall group. CONCLUSION: Elevated HS-CRP was associated with cardiovascular risk factors in normoinsulinemic PCOS without metabolic syndrome. These patients need more intensive screening or treatment for this disease. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/19771438/High_sensitive_serum_C_reactive_protein_and_its_relationship_with_other_cardiovascular_risk_factors_in_normoinsulinemic_polycystic_ovary_patients_without_metabolic_syndrome_ L2 - https://dx.doi.org/10.1007/s00404-009-1226-6 DB - PRIME DP - Unbound Medicine ER -