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[The Viriato Study: update of antimicrobial susceptibility data of bacterial pathogens from community-acquired respiratory tract infections in Portugal in 2001 and 2002].
Rev Port Pneumol. 2003 Jul-Aug; 9(4):293-310.RP

Abstract

The Viriato Study is a nationwide, prospective, multicenter surveillance study of the antimicrobial susceptibility of bacterial pathogens commonly associated with community-acquired respiratory tract infections in Portugal. In years 2001 and 2002, 31 laboratories participated in the study with a total of 2,600 strains, with testing undertaken in a central laboratory. Of the 486 Streptococcus pyogenes strains isolated from patients with acute tonsillitis all were susceptible to penicillin and other beta-lactams but 21.6% were resistant to erythromycin, clarithromycin and azithromycin. From patients with lower respiratory tract infection 1,071 strains of Streptococcus pneumoniae, 811 of Haemophilus influenzae, and 232 of Moraxella catarrhalis were studied. Among S. pneumoniae isolates 23% were resistant to penicillin (6.7% showing high-level resistance), 9.1% to cefuroxime, 1.0% to amoxycillin, 12.5% to erythromycin, clarithromycin and azithromycin, 10.9% to tetracycline, 29.8% to co-trimoxazol, and 3.0% to ofloxacin. Beta-lactamase was produced by 13.1% of H. influenzae and 94.4% of M. catarrhalis. In H. influenzae resistance to clarithromycin was 12.5% and to co-trimoxazole 15%. Most strains were susceptible to amoxycillin/clavulanate, cefuroxime, azithromycin, tetracycline and ciprofloxacin. In M. catarrhalis resistance to co-trimoxazole was 25%. All strains were susceptible to amoxycillin/clavulanate, cefuroxime, clarithromycin, azithromycin, tetracycline and ciprofloxacin. As verified in previous years of the Viriato Study, penicillin was the most active antimicrobial against S. pyogenes and amoxycillin/clavulanate the most active in vitro simultaneously against H. influenzae, S. pneumoniae and M. catarrhalis isolated from patients with community-acquired lower respiratory tract infection in Portugal.

Authors+Show Affiliations

Laboratório de Microbiologia, Faculdade de Medicina de Lisboa, Instituto Bacteriológico Câmara Pestana, Lisboa.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

por

PubMed ID

19771688

Citation

Melo-Cristino, J, et al. "[The Viriato Study: Update of Antimicrobial Susceptibility Data of Bacterial Pathogens From Community-acquired Respiratory Tract Infections in Portugal in 2001 and 2002]." Revista Portuguesa De Pneumologia, vol. 9, no. 4, 2003, pp. 293-310.
Melo-Cristino J, Serrano N, Grupo de Estudo Português de Bactérias Patogénicas Respiratórias. [The Viriato Study: update of antimicrobial susceptibility data of bacterial pathogens from community-acquired respiratory tract infections in Portugal in 2001 and 2002]. Rev Port Pneumol. 2003;9(4):293-310.
Melo-Cristino, J., & Serrano, N. (2003). [The Viriato Study: update of antimicrobial susceptibility data of bacterial pathogens from community-acquired respiratory tract infections in Portugal in 2001 and 2002]. Revista Portuguesa De Pneumologia, 9(4), 293-310.
Melo-Cristino J, Serrano N, Grupo de Estudo Português de Bactérias Patogénicas Respiratórias. [The Viriato Study: Update of Antimicrobial Susceptibility Data of Bacterial Pathogens From Community-acquired Respiratory Tract Infections in Portugal in 2001 and 2002]. Rev Port Pneumol. 2003 Jul-Aug;9(4):293-310. PubMed PMID: 19771688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The Viriato Study: update of antimicrobial susceptibility data of bacterial pathogens from community-acquired respiratory tract infections in Portugal in 2001 and 2002]. AU - Melo-Cristino,J, AU - Serrano,Nuno, AU - ,, PY - 2009/9/24/entrez PY - 2003/7/1/pubmed PY - 2009/11/17/medline SP - 293 EP - 310 JF - Revista portuguesa de pneumologia JO - Rev Port Pneumol VL - 9 IS - 4 N2 - The Viriato Study is a nationwide, prospective, multicenter surveillance study of the antimicrobial susceptibility of bacterial pathogens commonly associated with community-acquired respiratory tract infections in Portugal. In years 2001 and 2002, 31 laboratories participated in the study with a total of 2,600 strains, with testing undertaken in a central laboratory. Of the 486 Streptococcus pyogenes strains isolated from patients with acute tonsillitis all were susceptible to penicillin and other beta-lactams but 21.6% were resistant to erythromycin, clarithromycin and azithromycin. From patients with lower respiratory tract infection 1,071 strains of Streptococcus pneumoniae, 811 of Haemophilus influenzae, and 232 of Moraxella catarrhalis were studied. Among S. pneumoniae isolates 23% were resistant to penicillin (6.7% showing high-level resistance), 9.1% to cefuroxime, 1.0% to amoxycillin, 12.5% to erythromycin, clarithromycin and azithromycin, 10.9% to tetracycline, 29.8% to co-trimoxazol, and 3.0% to ofloxacin. Beta-lactamase was produced by 13.1% of H. influenzae and 94.4% of M. catarrhalis. In H. influenzae resistance to clarithromycin was 12.5% and to co-trimoxazole 15%. Most strains were susceptible to amoxycillin/clavulanate, cefuroxime, azithromycin, tetracycline and ciprofloxacin. In M. catarrhalis resistance to co-trimoxazole was 25%. All strains were susceptible to amoxycillin/clavulanate, cefuroxime, clarithromycin, azithromycin, tetracycline and ciprofloxacin. As verified in previous years of the Viriato Study, penicillin was the most active antimicrobial against S. pyogenes and amoxycillin/clavulanate the most active in vitro simultaneously against H. influenzae, S. pneumoniae and M. catarrhalis isolated from patients with community-acquired lower respiratory tract infection in Portugal. SN - 0873-2159 UR - https://www.unboundmedicine.com/medline/citation/19771688/[The_Viriato_Study:_update_of_antimicrobial_susceptibility_data_of_bacterial_pathogens_from_community_acquired_respiratory_tract_infections_in_Portugal_in_2001_and_2002]_ DB - PRIME DP - Unbound Medicine ER -