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Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus.
J Refract Surg. 2009 Sep; 25(9):S824-8.JR

Abstract

PURPOSE

Retrospective evaluation of haze development after riboflavin-ultraviolet (UV) A-induced corneal collagen cross-linking (CXL).

METHODS

One hundred sixty-three eyes of 127 patients with stage 1-3 keratoconus according to Krumeich's classification were included in this retrospective analysis. Follow-up was 1 year. Preoperatively and at all follow-up examinations uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), slit-lamp microscopic findings, corneal topography, and corneal thickness were recorded.

RESULTS

At 1 year after CXL, 149 (91.4%) eyes of 114 patients had a clear cornea without stromal haze (control group), whereas 14 eyes (8.6%) of 13 patients developed clinically significant stromal haze (haze group). Preoperatively, the mean keratometry (K) value of the apex was 62.1+/-13.8 diopters (D) in the control group and 71.1+/-13.2 D in the haze group (P=.02). The mean corneal thickness before the procedure was 478.1+/-52.4 mum in the control group and 420.0+/-33.9 mum in the haze group (P=.001). Uncorrected visual acuity and BSCVA, which were similar between groups preoperatively (P=.59 and P=.75, respectively), were improved in the control group (P=.023 and P=.001, respectively), but reduced in the haze group (P=.012 and P=.004, respectively) postoperatively.

CONCLUSIONS

The parameters defining the stage of keratoconus, such as K-value and corneal thickness, could be considered predicting factors for possible development of corneal haze after riboflavin-UVA-induced CXL. Advanced keratoconus should be considered at higher risk of haze development after CXL due to low corneal thickness and high corneal curvature.

Authors+Show Affiliations

Department of Ophthalmology, Carl Gustav Carus University Hospital, Dresden, Germany. Raiskup@uniklinikum-dresden.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19772259

Citation

Raiskup, Frederik, et al. "Permanent Corneal Haze After riboflavin-UVA-induced Cross-linking in Keratoconus." Journal of Refractive Surgery (Thorofare, N.J. : 1995), vol. 25, no. 9, 2009, pp. S824-8.
Raiskup F, Hoyer A, Spoerl E. Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. J Refract Surg. 2009;25(9):S824-8.
Raiskup, F., Hoyer, A., & Spoerl, E. (2009). Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. Journal of Refractive Surgery (Thorofare, N.J. : 1995), 25(9), S824-8. https://doi.org/10.3928/1081597X-20090813-12
Raiskup F, Hoyer A, Spoerl E. Permanent Corneal Haze After riboflavin-UVA-induced Cross-linking in Keratoconus. J Refract Surg. 2009;25(9):S824-8. PubMed PMID: 19772259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. AU - Raiskup,Frederik, AU - Hoyer,Anne, AU - Spoerl,Eberhard, Y1 - 2009/09/11/ PY - 2009/9/24/entrez PY - 2009/9/24/pubmed PY - 2009/12/16/medline SP - S824 EP - 8 JF - Journal of refractive surgery (Thorofare, N.J. : 1995) JO - J Refract Surg VL - 25 IS - 9 N2 - PURPOSE: Retrospective evaluation of haze development after riboflavin-ultraviolet (UV) A-induced corneal collagen cross-linking (CXL). METHODS: One hundred sixty-three eyes of 127 patients with stage 1-3 keratoconus according to Krumeich's classification were included in this retrospective analysis. Follow-up was 1 year. Preoperatively and at all follow-up examinations uncorrected visual acuity, best spectacle-corrected visual acuity (BSCVA), slit-lamp microscopic findings, corneal topography, and corneal thickness were recorded. RESULTS: At 1 year after CXL, 149 (91.4%) eyes of 114 patients had a clear cornea without stromal haze (control group), whereas 14 eyes (8.6%) of 13 patients developed clinically significant stromal haze (haze group). Preoperatively, the mean keratometry (K) value of the apex was 62.1+/-13.8 diopters (D) in the control group and 71.1+/-13.2 D in the haze group (P=.02). The mean corneal thickness before the procedure was 478.1+/-52.4 mum in the control group and 420.0+/-33.9 mum in the haze group (P=.001). Uncorrected visual acuity and BSCVA, which were similar between groups preoperatively (P=.59 and P=.75, respectively), were improved in the control group (P=.023 and P=.001, respectively), but reduced in the haze group (P=.012 and P=.004, respectively) postoperatively. CONCLUSIONS: The parameters defining the stage of keratoconus, such as K-value and corneal thickness, could be considered predicting factors for possible development of corneal haze after riboflavin-UVA-induced CXL. Advanced keratoconus should be considered at higher risk of haze development after CXL due to low corneal thickness and high corneal curvature. SN - 1081-597X UR - https://www.unboundmedicine.com/medline/citation/19772259/Permanent_corneal_haze_after_riboflavin_UVA_induced_cross_linking_in_keratoconus_ L2 - https://www.healio.com/doiresolver?doi=10.3928/1081597X-20090813-12 DB - PRIME DP - Unbound Medicine ER -