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Emerging drugs for acne.
Expert Opin Emerg Drugs. 2009 Dec; 14(4):649-59.EO

Abstract

Acne vulgaris is a common skin disorder that affects most individuals at some point in their lives. It may result in significant morbidity, including cutaneous scarring and psychological impairment. Current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, and systemic isotretinoin. There are growing concerns of rising antibiotic resistance, significant side effects of isotretinoin therapy, and lack of safe and effective treatment for pregnant females. Recent advances in the pathogenesis of acne have led to a greater understanding of the underlying inflammatory mechanisms and the role the Propionibacterium acnes and biofilms. This has led to the development of new therapeutic targets. This article reviews emerging treatments of acne, including topical picolinic acid, topical antibiotic dapsone, systemic zinc salts, oral antibiotic lymecycline, new formulations of and synergistic combinations of benzoyl peroxide, photodynamic therapy with topical photosensitizers and potential acne vaccines.

Authors+Show Affiliations

UNC School of Medicine- Dermatology, Chapel Hill, North Carolina 27516, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19772370

Citation

James, Kirk A., et al. "Emerging Drugs for Acne." Expert Opinion On Emerging Drugs, vol. 14, no. 4, 2009, pp. 649-59.
James KA, Burkhart CN, Morrell DS. Emerging drugs for acne. Expert Opin Emerg Drugs. 2009;14(4):649-59.
James, K. A., Burkhart, C. N., & Morrell, D. S. (2009). Emerging drugs for acne. Expert Opinion On Emerging Drugs, 14(4), 649-59. https://doi.org/10.1517/14728210903251690
James KA, Burkhart CN, Morrell DS. Emerging Drugs for Acne. Expert Opin Emerg Drugs. 2009;14(4):649-59. PubMed PMID: 19772370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging drugs for acne. AU - James,Kirk A, AU - Burkhart,Craig N, AU - Morrell,Dean S, PY - 2009/9/24/entrez PY - 2009/9/24/pubmed PY - 2010/2/18/medline SP - 649 EP - 59 JF - Expert opinion on emerging drugs JO - Expert Opin Emerg Drugs VL - 14 IS - 4 N2 - Acne vulgaris is a common skin disorder that affects most individuals at some point in their lives. It may result in significant morbidity, including cutaneous scarring and psychological impairment. Current treatments include topical retinoids, benzoyl peroxide, topical and systemic antibiotics, and systemic isotretinoin. There are growing concerns of rising antibiotic resistance, significant side effects of isotretinoin therapy, and lack of safe and effective treatment for pregnant females. Recent advances in the pathogenesis of acne have led to a greater understanding of the underlying inflammatory mechanisms and the role the Propionibacterium acnes and biofilms. This has led to the development of new therapeutic targets. This article reviews emerging treatments of acne, including topical picolinic acid, topical antibiotic dapsone, systemic zinc salts, oral antibiotic lymecycline, new formulations of and synergistic combinations of benzoyl peroxide, photodynamic therapy with topical photosensitizers and potential acne vaccines. SN - 1744-7623 UR - https://www.unboundmedicine.com/medline/citation/19772370/Emerging_drugs_for_acne_ L2 - https://www.tandfonline.com/doi/full/10.1517/14728210903251690 DB - PRIME DP - Unbound Medicine ER -