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New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.
Curr Rheumatol Rep 2009; 11(5):329-33CR

Abstract

In 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. Despite recent advances in our understanding of the epidemiologic, pathophysiologic, and immunogenetic mechanisms involved in SAPHO syndrome, etiopathogenesis remains poorly understood. Propionibacterium acnes, the microorganism associated with acne, has been recovered on bone biopsy in some patients, but the possible pathogenetic role of an infectious agent in a genetically predisposed individual, resulting in exaggerated inflammatory response as "reactive osteitis," is a largely unproven hypothesis. The newly available whole-body MRI will assist early diagnosis by detecting multifocal osteitis lesions, some of them asymptomatic, in axial (anterior chest wall, spine, and jaws) and nonaxial sites. Moreover, outcomes are vastly improved by treatment with bisphosphonates and tumor necrosis factor-alpha antagonists.

Authors+Show Affiliations

Division of Rheumatology, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA. mkhan@metrohealth.orgNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19772827

Citation

Magrey, Marina, and Muhammad A. Khan. "New Insights Into Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome." Current Rheumatology Reports, vol. 11, no. 5, 2009, pp. 329-33.
Magrey M, Khan MA. New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Curr Rheumatol Rep. 2009;11(5):329-33.
Magrey, M., & Khan, M. A. (2009). New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Current Rheumatology Reports, 11(5), pp. 329-33.
Magrey M, Khan MA. New Insights Into Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. Curr Rheumatol Rep. 2009;11(5):329-33. PubMed PMID: 19772827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. AU - Magrey,Marina, AU - Khan,Muhammad A, PY - 2009/9/24/entrez PY - 2009/9/24/pubmed PY - 2009/12/23/medline SP - 329 EP - 33 JF - Current rheumatology reports JO - Curr Rheumatol Rep VL - 11 IS - 5 N2 - In 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, synovitis, and multifocal aseptic osteomyelitis, observed in association with dermatologic conditions such as palmoplantar pustulosis, severe acne, and hidradenitis suppurativa. Despite recent advances in our understanding of the epidemiologic, pathophysiologic, and immunogenetic mechanisms involved in SAPHO syndrome, etiopathogenesis remains poorly understood. Propionibacterium acnes, the microorganism associated with acne, has been recovered on bone biopsy in some patients, but the possible pathogenetic role of an infectious agent in a genetically predisposed individual, resulting in exaggerated inflammatory response as "reactive osteitis," is a largely unproven hypothesis. The newly available whole-body MRI will assist early diagnosis by detecting multifocal osteitis lesions, some of them asymptomatic, in axial (anterior chest wall, spine, and jaws) and nonaxial sites. Moreover, outcomes are vastly improved by treatment with bisphosphonates and tumor necrosis factor-alpha antagonists. SN - 1534-6307 UR - https://www.unboundmedicine.com/medline/citation/19772827/New_insights_into_synovitis_acne_pustulosis_hyperostosis_and_osteitis__SAPHO__syndrome_ L2 - http://www.diseaseinfosearch.org/result/6411 DB - PRIME DP - Unbound Medicine ER -