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Abnormal essential fatty acid metabolism in Darier's disease.
Arch Dermatol. 1990 Oct; 126(10):1308-11.AD

Abstract

Fatty acid levels in plasma and erythrocyte cell membranes were determined in 13 Danish patients with Darier's disease and 21 Danish controls. Concentrations of the main dietary essential fatty acids, linoleic acid (18:2n-6) and alpha-linolenic acid (18:3n-3), were consistently modestly above normal; concentrations of the delta 6-desaturase metabolites of both linoleic and alpha-linolenic acids, however, were consistently and often significantly below normal. These results suggest that the capacity of the enzyme delta 6-desaturase activity is inadequate in patients with Darier's disease.

Authors+Show Affiliations

Department of Dermatology, University of California, San Francisco.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1977367

Citation

Oxholm, A, et al. "Abnormal Essential Fatty Acid Metabolism in Darier's Disease." Archives of Dermatology, vol. 126, no. 10, 1990, pp. 1308-11.
Oxholm A, Oxholm P, da Cunha Bang F, et al. Abnormal essential fatty acid metabolism in Darier's disease. Arch Dermatol. 1990;126(10):1308-11.
Oxholm, A., Oxholm, P., da Cunha Bang, F., & Horrobin, D. F. (1990). Abnormal essential fatty acid metabolism in Darier's disease. Archives of Dermatology, 126(10), 1308-11.
Oxholm A, et al. Abnormal Essential Fatty Acid Metabolism in Darier's Disease. Arch Dermatol. 1990;126(10):1308-11. PubMed PMID: 1977367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal essential fatty acid metabolism in Darier's disease. AU - Oxholm,A, AU - Oxholm,P, AU - da Cunha Bang,F, AU - Horrobin,D F, PY - 1990/10/1/pubmed PY - 1990/10/1/medline PY - 1990/10/1/entrez SP - 1308 EP - 11 JF - Archives of dermatology JO - Arch Dermatol VL - 126 IS - 10 N2 - Fatty acid levels in plasma and erythrocyte cell membranes were determined in 13 Danish patients with Darier's disease and 21 Danish controls. Concentrations of the main dietary essential fatty acids, linoleic acid (18:2n-6) and alpha-linolenic acid (18:3n-3), were consistently modestly above normal; concentrations of the delta 6-desaturase metabolites of both linoleic and alpha-linolenic acids, however, were consistently and often significantly below normal. These results suggest that the capacity of the enzyme delta 6-desaturase activity is inadequate in patients with Darier's disease. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/1977367/Abnormal_essential_fatty_acid_metabolism_in_Darier's_disease_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/126/pg/1308 DB - PRIME DP - Unbound Medicine ER -