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Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men.
J Bone Miner Res. 2010 Mar; 25(3):545-53.JB

Abstract

The association between vitamin D levels and incident fractures in older men is uncertain. To test the hypothesis that low serum 25-hydroxyvitamin D [(25(OH)D] levels are associated with an increased risk of fracture, we performed a case-cohort study of 436 men with incident nonspine fractures, including 81 hip fractures, and a random subcohort of 1608 men; average follow-up time 5.3 years. Serum vitamin D(2) and vitamin D(3) were measured on baseline sera using mass spectrometry and summed for total vitamin D. Modified Cox proportional hazards models were used to estimate the hazard ratio (HR) of fracture with 95% confidence intervals (CIs). Multivariable models included age, clinic, season, race, height, weight, and physical activity. The mean (SD) total 25(OH)D was 24.6 (7.8) ng/mL in nonspine fracture subjects, 21.5 (7.9) ng/mL in hip fracture subjects, and 25.2 (7.8) ng/mL in controls (nonspine fracture subjects versus nonpatients, p = .14; hip fracture subjects versus controls, p < .0001). 25(OH)D levels were unrelated to nonspine fractures. One SD decrease in total 25(OH)D was associated with an increased risk of hip fracture (multivariate HR = 1.60; 95% CI 1.18-2.17). Compared with men in the top quartile of total 25(OH)D (> or =28), the HR of hip fracture was 2.36 (95% CI 1.08-5.15) for men in the lowest quartile (<20) (p = .009 for trend). Adjusting for hip bone mineral density attenuated the association by more than 50% (p = .065 for trend). Low serum 25(OH)D concentrations are associated with a higher risk of hip fracture in older men. Measurement of 25(OH)D may be useful in identifying men at high risk of hip fracture.

Authors+Show Affiliations

University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA. jcauley@edc.pitt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19775201

Citation

Cauley, Jane A., et al. "Serum 25-hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 25, no. 3, 2010, pp. 545-53.
Cauley JA, Parimi N, Ensrud KE, et al. Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res. 2010;25(3):545-53.
Cauley, J. A., Parimi, N., Ensrud, K. E., Bauer, D. C., Cawthon, P. M., Cummings, S. R., Hoffman, A. R., Shikany, J. M., Barrett-Connor, E., & Orwoll, E. (2010). Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 25(3), 545-53. https://doi.org/10.1359/jbmr.090826
Cauley JA, et al. Serum 25-hydroxyvitamin D and the Risk of Hip and Nonspine Fractures in Older Men. J Bone Miner Res. 2010;25(3):545-53. PubMed PMID: 19775201.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. AU - Cauley,Jane A, AU - Parimi,Neeta, AU - Ensrud,Kristine E, AU - Bauer,Douglas C, AU - Cawthon,Peggy M, AU - Cummings,Steven R, AU - Hoffman,Andrew R, AU - Shikany,James M, AU - Barrett-Connor,Elizabeth, AU - Orwoll,Eric, AU - ,, PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/10/28/medline SP - 545 EP - 53 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 25 IS - 3 N2 - The association between vitamin D levels and incident fractures in older men is uncertain. To test the hypothesis that low serum 25-hydroxyvitamin D [(25(OH)D] levels are associated with an increased risk of fracture, we performed a case-cohort study of 436 men with incident nonspine fractures, including 81 hip fractures, and a random subcohort of 1608 men; average follow-up time 5.3 years. Serum vitamin D(2) and vitamin D(3) were measured on baseline sera using mass spectrometry and summed for total vitamin D. Modified Cox proportional hazards models were used to estimate the hazard ratio (HR) of fracture with 95% confidence intervals (CIs). Multivariable models included age, clinic, season, race, height, weight, and physical activity. The mean (SD) total 25(OH)D was 24.6 (7.8) ng/mL in nonspine fracture subjects, 21.5 (7.9) ng/mL in hip fracture subjects, and 25.2 (7.8) ng/mL in controls (nonspine fracture subjects versus nonpatients, p = .14; hip fracture subjects versus controls, p < .0001). 25(OH)D levels were unrelated to nonspine fractures. One SD decrease in total 25(OH)D was associated with an increased risk of hip fracture (multivariate HR = 1.60; 95% CI 1.18-2.17). Compared with men in the top quartile of total 25(OH)D (> or =28), the HR of hip fracture was 2.36 (95% CI 1.08-5.15) for men in the lowest quartile (<20) (p = .009 for trend). Adjusting for hip bone mineral density attenuated the association by more than 50% (p = .065 for trend). Low serum 25(OH)D concentrations are associated with a higher risk of hip fracture in older men. Measurement of 25(OH)D may be useful in identifying men at high risk of hip fracture. SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/19775201/Serum_25_hydroxyvitamin_D_and_the_risk_of_hip_and_nonspine_fractures_in_older_men_ L2 - https://doi.org/10.1359/jbmr.090826 DB - PRIME DP - Unbound Medicine ER -