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Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis.
BJOG 2009; 116(13):1697-705BJOG

Abstract

BACKGROUND

Epidemiology studies have reported associations between soy intake and the risk of endocrine-related gynaecological cancers. However, to date there have been no quantitative meta-analyses reported regarding this topic.

OBJECTIVES

We investigated the quantitative associations between soy food intake and the risk of endometrial cancer and ovarian cancer by a meta-analysis of case-control studies and cohort studies.

SEARCH STRATEGY

We searched MEDLINE (PubMed), EMBASE and the Cochrane Library during October 2008 using common keywords related to soy intake and endometrial or ovarian cancer. Two evaluators independently reviewed and selected articles, based on predetermined selection criteria.

SELECTION CRITERIA

Included studies met all of the following criteria: (1) a case-control study or cohort study (to date, no randomized controlled trials have been reported); (2) investigated the associations between 'soy or soy product intake' and 'endometrial cancer' or 'ovarian cancer'; (3) reported outcome measures with adjusted odds ratios (OR) or relative risks (RR) and 95% confidence intervals (CI).

DATA COLLECTION AND ANALYSIS

We investigated the associations between the overall soy intake (highest versus lowest intake) and the risk of endocrine-related gynaecological cancers (endometrial or ovarian cancer) as the main analysis. We also performed subgroup analyses by type of cancer (endometrial or ovarian), type of study design (case-control or cohort) and type of soy intake (soy foods or soy constituents).

MAIN RESULTS

Out of 477 articles that met our initial criteria, a total of seven epidemiology studies consisting of five case-control studies and two cohort studies were included in the final analyses. Compared with the lowest soy intake, the OR for the highest soy intake was 0.61 (95% CI, 0.53-0.72) of all endocrine-related cancers among seven studies; 0.70 for endometrial cancer (95% CI, 0.57-0.86) and 0.52 for ovarian cancer (95% CI, 0.42-0.66) in the fixed-effects meta-analyses. The subgroup analyses by study design showed similar findings among the case-control studies (OR, 0.62; 95% CI, 0.53-0.73) and the cohort studies (OR, 0.57; 95% CI, 0.36-0.90).

AUTHOR'S CONCLUSIONS

The results of the current study showed protective effects of soy intake on the risk for endocrine-related gynaecological cancers. Additional larger prospective studies are now needed.

Authors+Show Affiliations

Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Korea. msk@ncc.re.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

19775307

Citation

Myung, S-K, et al. "Soy Intake and Risk of Endocrine-related Gynaecological Cancer: a Meta-analysis." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 116, no. 13, 2009, pp. 1697-705.
Myung SK, Ju W, Choi HJ, et al. Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis. BJOG. 2009;116(13):1697-705.
Myung, S. K., Ju, W., Choi, H. J., & Kim, S. C. (2009). Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis. BJOG : an International Journal of Obstetrics and Gynaecology, 116(13), pp. 1697-705. doi:10.1111/j.1471-0528.2009.02322.x.
Myung SK, et al. Soy Intake and Risk of Endocrine-related Gynaecological Cancer: a Meta-analysis. BJOG. 2009;116(13):1697-705. PubMed PMID: 19775307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy intake and risk of endocrine-related gynaecological cancer: a meta-analysis. AU - Myung,S-K, AU - Ju,W, AU - Choi,H J, AU - Kim,S C, AU - ,, Y1 - 2009/09/19/ PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/1/29/medline SP - 1697 EP - 705 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 116 IS - 13 N2 - BACKGROUND: Epidemiology studies have reported associations between soy intake and the risk of endocrine-related gynaecological cancers. However, to date there have been no quantitative meta-analyses reported regarding this topic. OBJECTIVES: We investigated the quantitative associations between soy food intake and the risk of endometrial cancer and ovarian cancer by a meta-analysis of case-control studies and cohort studies. SEARCH STRATEGY: We searched MEDLINE (PubMed), EMBASE and the Cochrane Library during October 2008 using common keywords related to soy intake and endometrial or ovarian cancer. Two evaluators independently reviewed and selected articles, based on predetermined selection criteria. SELECTION CRITERIA: Included studies met all of the following criteria: (1) a case-control study or cohort study (to date, no randomized controlled trials have been reported); (2) investigated the associations between 'soy or soy product intake' and 'endometrial cancer' or 'ovarian cancer'; (3) reported outcome measures with adjusted odds ratios (OR) or relative risks (RR) and 95% confidence intervals (CI). DATA COLLECTION AND ANALYSIS: We investigated the associations between the overall soy intake (highest versus lowest intake) and the risk of endocrine-related gynaecological cancers (endometrial or ovarian cancer) as the main analysis. We also performed subgroup analyses by type of cancer (endometrial or ovarian), type of study design (case-control or cohort) and type of soy intake (soy foods or soy constituents). MAIN RESULTS: Out of 477 articles that met our initial criteria, a total of seven epidemiology studies consisting of five case-control studies and two cohort studies were included in the final analyses. Compared with the lowest soy intake, the OR for the highest soy intake was 0.61 (95% CI, 0.53-0.72) of all endocrine-related cancers among seven studies; 0.70 for endometrial cancer (95% CI, 0.57-0.86) and 0.52 for ovarian cancer (95% CI, 0.42-0.66) in the fixed-effects meta-analyses. The subgroup analyses by study design showed similar findings among the case-control studies (OR, 0.62; 95% CI, 0.53-0.73) and the cohort studies (OR, 0.57; 95% CI, 0.36-0.90). AUTHOR'S CONCLUSIONS: The results of the current study showed protective effects of soy intake on the risk for endocrine-related gynaecological cancers. Additional larger prospective studies are now needed. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/19775307/Soy_intake_and_risk_of_endocrine_related_gynaecological_cancer:_a_meta_analysis_ L2 - https://doi.org/10.1111/j.1471-0528.2009.02322.x DB - PRIME DP - Unbound Medicine ER -