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Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?
Br J Dermatol 2009; 161 Suppl 3:54-60BJ

Abstract

Because solar UV-radiation represents the most important environmental risk factor for the development of non-melanoma skin cancer, UV protection is important to prevent these malignancies. Consequently, public health campaigns were developed to improve the knowledge of the general population regarding the role of UV-radiation for the development of skin cancer. However, it has to be noted that vitamin D-mediated positive effects of UV light were not adequately considered in most of these campaigns, that often propose a strict 'no sun policy' without giving recommendations how to prevent vitamin D-deficiency. Under our living conditions, approximately 90% of all vitamin D needed by the human body has to be formed in the skin through the action of UV-B-radiation and it has been shown that strict sun protection causes vitamin D-deficiency. This dilemma represents a serious problem, for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer, bone diseases, autoimmune diseases, infectious diseases, cardiovascular diseases and hypertension has now been reported in a large number of laboratory and epidemiologic investigations. Although further work is necessary to define an adequate vitamin D-status and adequate guidelines for UV-exposure, it is at present mandatory that guidelines for UV-exposure (e.g. in skin cancer prevention campaigns) consider these facts and give recommendations how to prevent vitamin D-deficiency. At present, most experts in the field agree that the evidence to date suggests that daily intake of 1000-2000 IU vitamin D could reduce the incidence of vitamin D-deficiency-related diseases with minimal risk in Europe, the US, and other countries. In this review, we analyze the present literature to help developing well-balanced guidelines on UV-protection that ensure an adequate vitamin D-status. These recommendations will hopefully protect us against vitamin D-deficiency without increasing the risk to develop UV-induced skin cancer.

Authors+Show Affiliations

Klinik für Dermatologie, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany. hajrei@uniklinik-saarland.de

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19775358

Citation

Reichrath, J. "Skin Cancer Prevention and UV-protection: How to Avoid Vitamin D-deficiency?" The British Journal of Dermatology, vol. 161 Suppl 3, 2009, pp. 54-60.
Reichrath J. Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency? Br J Dermatol. 2009;161 Suppl 3:54-60.
Reichrath, J. (2009). Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency? The British Journal of Dermatology, 161 Suppl 3, pp. 54-60. doi:10.1111/j.1365-2133.2009.09450.x.
Reichrath J. Skin Cancer Prevention and UV-protection: How to Avoid Vitamin D-deficiency. Br J Dermatol. 2009;161 Suppl 3:54-60. PubMed PMID: 19775358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency? A1 - Reichrath,J, PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/3/11/medline SP - 54 EP - 60 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 161 Suppl 3 N2 - Because solar UV-radiation represents the most important environmental risk factor for the development of non-melanoma skin cancer, UV protection is important to prevent these malignancies. Consequently, public health campaigns were developed to improve the knowledge of the general population regarding the role of UV-radiation for the development of skin cancer. However, it has to be noted that vitamin D-mediated positive effects of UV light were not adequately considered in most of these campaigns, that often propose a strict 'no sun policy' without giving recommendations how to prevent vitamin D-deficiency. Under our living conditions, approximately 90% of all vitamin D needed by the human body has to be formed in the skin through the action of UV-B-radiation and it has been shown that strict sun protection causes vitamin D-deficiency. This dilemma represents a serious problem, for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer, bone diseases, autoimmune diseases, infectious diseases, cardiovascular diseases and hypertension has now been reported in a large number of laboratory and epidemiologic investigations. Although further work is necessary to define an adequate vitamin D-status and adequate guidelines for UV-exposure, it is at present mandatory that guidelines for UV-exposure (e.g. in skin cancer prevention campaigns) consider these facts and give recommendations how to prevent vitamin D-deficiency. At present, most experts in the field agree that the evidence to date suggests that daily intake of 1000-2000 IU vitamin D could reduce the incidence of vitamin D-deficiency-related diseases with minimal risk in Europe, the US, and other countries. In this review, we analyze the present literature to help developing well-balanced guidelines on UV-protection that ensure an adequate vitamin D-status. These recommendations will hopefully protect us against vitamin D-deficiency without increasing the risk to develop UV-induced skin cancer. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/19775358/Skin_cancer_prevention_and_UV_protection:_how_to_avoid_vitamin_D_deficiency L2 - https://doi.org/10.1111/j.1365-2133.2009.09450.x DB - PRIME DP - Unbound Medicine ER -