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Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol.

Abstract

Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta 9-tetrahydrocannabinol (Delta 9-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta 9-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocritical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties.

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  • Authors+Show Affiliations

    ,

    Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, King's College London, UK. p.fusar@libero.it

    , , , , , , , , , ,

    Source

    MeSH

    Adult
    Amygdala
    Cannabidiol
    Double-Blind Method
    Dronabinol
    Emotions
    Facial Expression
    Gyrus Cinguli
    Humans
    Magnetic Resonance Imaging
    Male
    Models, Neurological
    Neural Pathways
    Placebos
    Psychotropic Drugs

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19775500

    Citation

    Fusar-Poli, Paolo, et al. "Modulation of Effective Connectivity During Emotional Processing By Delta 9-tetrahydrocannabinol and Cannabidiol." The International Journal of Neuropsychopharmacology, vol. 13, no. 4, 2010, pp. 421-32.
    Fusar-Poli P, Allen P, Bhattacharyya S, et al. Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. Int J Neuropsychopharmacol. 2010;13(4):421-32.
    Fusar-Poli, P., Allen, P., Bhattacharyya, S., Crippa, J. A., Mechelli, A., Borgwardt, S., ... McGuire, P. (2010). Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. The International Journal of Neuropsychopharmacology, 13(4), pp. 421-32. doi:10.1017/S1461145709990617.
    Fusar-Poli P, et al. Modulation of Effective Connectivity During Emotional Processing By Delta 9-tetrahydrocannabinol and Cannabidiol. Int J Neuropsychopharmacol. 2010;13(4):421-32. PubMed PMID: 19775500.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. AU - Fusar-Poli,Paolo, AU - Allen,Paul, AU - Bhattacharyya,Sagnik, AU - Crippa,José A, AU - Mechelli,Andrea, AU - Borgwardt,Stefan, AU - Martin-Santos,Rocio, AU - Seal,Marc L, AU - O'Carrol,Colin, AU - Atakan,Zerrin, AU - Zuardi,Antonio W, AU - McGuire,Philip, Y1 - 2009/09/24/ PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/7/16/medline SP - 421 EP - 32 JF - The international journal of neuropsychopharmacology JO - Int. J. Neuropsychopharmacol. VL - 13 IS - 4 N2 - Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta 9-tetrahydrocannabinol (Delta 9-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta 9-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocritical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties. SN - 1469-5111 UR - https://www.unboundmedicine.com/medline/citation/19775500/Modulation_of_effective_connectivity_during_emotional_processing_by_Delta_9_tetrahydrocannabinol_and_cannabidiol_ L2 - https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S1461145709990617 DB - PRIME DP - Unbound Medicine ER -