Tags

Type your tag names separated by a space and hit enter

Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol.
Int J Neuropsychopharmacol 2010; 13(4):421-32IJ

Abstract

Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta 9-tetrahydrocannabinol (Delta 9-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta 9-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocritical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties.

Authors+Show Affiliations

Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, King's College London, UK. p.fusar@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19775500

Citation

Fusar-Poli, Paolo, et al. "Modulation of Effective Connectivity During Emotional Processing By Delta 9-tetrahydrocannabinol and Cannabidiol." The International Journal of Neuropsychopharmacology, vol. 13, no. 4, 2010, pp. 421-32.
Fusar-Poli P, Allen P, Bhattacharyya S, et al. Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. Int J Neuropsychopharmacol. 2010;13(4):421-32.
Fusar-Poli, P., Allen, P., Bhattacharyya, S., Crippa, J. A., Mechelli, A., Borgwardt, S., ... McGuire, P. (2010). Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. The International Journal of Neuropsychopharmacology, 13(4), pp. 421-32. doi:10.1017/S1461145709990617.
Fusar-Poli P, et al. Modulation of Effective Connectivity During Emotional Processing By Delta 9-tetrahydrocannabinol and Cannabidiol. Int J Neuropsychopharmacol. 2010;13(4):421-32. PubMed PMID: 19775500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol. AU - Fusar-Poli,Paolo, AU - Allen,Paul, AU - Bhattacharyya,Sagnik, AU - Crippa,José A, AU - Mechelli,Andrea, AU - Borgwardt,Stefan, AU - Martin-Santos,Rocio, AU - Seal,Marc L, AU - O'Carrol,Colin, AU - Atakan,Zerrin, AU - Zuardi,Antonio W, AU - McGuire,Philip, Y1 - 2009/09/24/ PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/7/16/medline SP - 421 EP - 32 JF - The international journal of neuropsychopharmacology JO - Int. J. Neuropsychopharmacol. VL - 13 IS - 4 N2 - Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta 9-tetrahydrocannabinol (Delta 9-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta 9-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocritical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties. SN - 1469-5111 UR - https://www.unboundmedicine.com/medline/citation/19775500/Modulation_of_effective_connectivity_during_emotional_processing_by_Delta_9_tetrahydrocannabinol_and_cannabidiol_ L2 - https://academic.oup.com/ijnp/article-lookup/doi/10.1017/S1461145709990617 DB - PRIME DP - Unbound Medicine ER -