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Preoperative staging of liver metastases from uveal melanoma by magnetic resonance imaging (MRI) and fluorodeoxyglucose-positron emission tomography (FDG-PET).
Eur J Surg Oncol. 2010 Feb; 36(2):189-94.EJ

Abstract

BACKGROUND

Microscopically complete (R0) resection of metastases from uveal melanoma prolongs median overall survival compared to incomplete surgery. The aim of this study was to compare the sensitivity of dynamic-enhanced magnetic resonance imaging (MRI) with fluorodeoxyglucose-positron emission tomography (FDG-PET) in the preoperative diagnosis of liver metastases from uveal melanoma.

PATIENTS AND METHODS

Fifteen consecutive patients (mean age: 56 years) underwent FDG-PET and liver MRI. Extrahepatic metastatic disease was excluded by whole body computed tomography and bone scintigraphy. MRI and FDG-PET were performed with a mean of 19 days (range: 1-30) before surgery. Imaging findings were compared with surgical (including intraoperative ultrasonography) and histological findings on a lesion by lesion analysis.

RESULTS

R0 resection was performed in 12 patients. A total of 28 lesions were resected with 27 histologically proven metastases. Nine lesions were smaller than 5mm, 7 measured 5-10mm and 11 were larger than 10mm. Sensitivity and positive predictive value were 67% and 95% for MRI compared to 41% and 100% for FDG-PET. The difference between the two modalities was statistically significant (p=0.01; McNemar test). In remaining 3 patients, diffuse miliary disease (>10 capsular lesions) was discovered intraoperatively, and was suspected on preoperative MRI in 2 cases. Only one extrahepatic lesion identified by FDG-PET was falsely positive.

CONCLUSIONS

In this preliminary study, MRI was superior to FDG-PET for staging of liver metastases from uveal melanoma. Although miliary disease was suggested by MRI in some cases, preoperative confirmation remains imperfect.

Authors+Show Affiliations

Department of Radiology and Nuclear Medicine, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19775851

Citation

Servois, V, et al. "Preoperative Staging of Liver Metastases From Uveal Melanoma By Magnetic Resonance Imaging (MRI) and Fluorodeoxyglucose-positron Emission Tomography (FDG-PET)." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 36, no. 2, 2010, pp. 189-94.
Servois V, Mariani P, Malhaire C, et al. Preoperative staging of liver metastases from uveal melanoma by magnetic resonance imaging (MRI) and fluorodeoxyglucose-positron emission tomography (FDG-PET). Eur J Surg Oncol. 2010;36(2):189-94.
Servois, V., Mariani, P., Malhaire, C., Petras, S., Piperno-Neumann, S., Plancher, C., Levy-Gabriel, C., Lumbroso-le Rouic, L., Desjardins, L., & Salmon, R. J. (2010). Preoperative staging of liver metastases from uveal melanoma by magnetic resonance imaging (MRI) and fluorodeoxyglucose-positron emission tomography (FDG-PET). European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 36(2), 189-94. https://doi.org/10.1016/j.ejso.2009.08.010
Servois V, et al. Preoperative Staging of Liver Metastases From Uveal Melanoma By Magnetic Resonance Imaging (MRI) and Fluorodeoxyglucose-positron Emission Tomography (FDG-PET). Eur J Surg Oncol. 2010;36(2):189-94. PubMed PMID: 19775851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative staging of liver metastases from uveal melanoma by magnetic resonance imaging (MRI) and fluorodeoxyglucose-positron emission tomography (FDG-PET). AU - Servois,V, AU - Mariani,P, AU - Malhaire,C, AU - Petras,S, AU - Piperno-Neumann,S, AU - Plancher,C, AU - Levy-Gabriel,C, AU - Lumbroso-le Rouic,L, AU - Desjardins,L, AU - Salmon,R J, Y1 - 2009/09/22/ PY - 2009/06/17/received PY - 2009/08/18/revised PY - 2009/08/23/accepted PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/3/2/medline SP - 189 EP - 94 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 36 IS - 2 N2 - BACKGROUND: Microscopically complete (R0) resection of metastases from uveal melanoma prolongs median overall survival compared to incomplete surgery. The aim of this study was to compare the sensitivity of dynamic-enhanced magnetic resonance imaging (MRI) with fluorodeoxyglucose-positron emission tomography (FDG-PET) in the preoperative diagnosis of liver metastases from uveal melanoma. PATIENTS AND METHODS: Fifteen consecutive patients (mean age: 56 years) underwent FDG-PET and liver MRI. Extrahepatic metastatic disease was excluded by whole body computed tomography and bone scintigraphy. MRI and FDG-PET were performed with a mean of 19 days (range: 1-30) before surgery. Imaging findings were compared with surgical (including intraoperative ultrasonography) and histological findings on a lesion by lesion analysis. RESULTS: R0 resection was performed in 12 patients. A total of 28 lesions were resected with 27 histologically proven metastases. Nine lesions were smaller than 5mm, 7 measured 5-10mm and 11 were larger than 10mm. Sensitivity and positive predictive value were 67% and 95% for MRI compared to 41% and 100% for FDG-PET. The difference between the two modalities was statistically significant (p=0.01; McNemar test). In remaining 3 patients, diffuse miliary disease (>10 capsular lesions) was discovered intraoperatively, and was suspected on preoperative MRI in 2 cases. Only one extrahepatic lesion identified by FDG-PET was falsely positive. CONCLUSIONS: In this preliminary study, MRI was superior to FDG-PET for staging of liver metastases from uveal melanoma. Although miliary disease was suggested by MRI in some cases, preoperative confirmation remains imperfect. SN - 1532-2157 UR - https://www.unboundmedicine.com/medline/citation/19775851/Preoperative_staging_of_liver_metastases_from_uveal_melanoma_by_magnetic_resonance_imaging__MRI__and_fluorodeoxyglucose_positron_emission_tomography__FDG_PET__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0748-7983(09)00442-9 DB - PRIME DP - Unbound Medicine ER -