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Neuropsychological changes 1-year after subthalamic DBS in PD patients: A prospective controlled study.
Parkinsonism Relat Disord. 2010 Feb; 16(2):115-8.PR

Abstract

OBJECTIVE

This study aimed at investigating the neuropsychological effect of DBS of the Subthalamic Nucleus in patients with advanced Parkinson's disease (PD).

METHODS

A standardized neuropsychological test battery, assessing reasoning, memory and executive functions, was administered to 27 PD patients who underwent DBS-STN (DBS group) and to a matched control group of 31 PD patients under optimal medical treatment (MED group). Patients were evaluated at baseline and at the end of 1 year.

RESULTS

Change score analysis (T1 minus T0 scores) demonstrated a significant decline in phonemic verbal fluency in the DBS group compared with the MED group (p < 0.005), while there were no significant changes between the two groups for the other cognitive tests. Single cases analysis by means of multivariate normative comparisons revealed that 4 out of 27 DBS patients (15%) showed cognitive deterioration one year post surgery. These patients were significantly more compromised from a motor standpoint (UPDRS, section III) than the 23 DBS PD patients who had no cognitive decline post surgery.

CONCLUSION

Results of this prospective controlled-study showed that phonemic verbal fluency declined one year after DBS-STN, while the other cognitive domains did not change significantly. Nevertheless, single case analysis highlighted the fact that a subgroup comprising 15% of DBS-STN patients (4/27) showed significant cognitive decline 1 year after surgery.

Authors+Show Affiliations

Department of Neuroscience, University of Turin, via Cherasco 15, 10126 Turin, Italy. castelli_lorys@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19775926

Citation

Castelli, Lorys, et al. "Neuropsychological Changes 1-year After Subthalamic DBS in PD Patients: a Prospective Controlled Study." Parkinsonism & Related Disorders, vol. 16, no. 2, 2010, pp. 115-8.
Castelli L, Rizzi L, Zibetti M, et al. Neuropsychological changes 1-year after subthalamic DBS in PD patients: A prospective controlled study. Parkinsonism Relat Disord. 2010;16(2):115-8.
Castelli, L., Rizzi, L., Zibetti, M., Angrisano, S., Lanotte, M., & Lopiano, L. (2010). Neuropsychological changes 1-year after subthalamic DBS in PD patients: A prospective controlled study. Parkinsonism & Related Disorders, 16(2), 115-8. https://doi.org/10.1016/j.parkreldis.2009.08.010
Castelli L, et al. Neuropsychological Changes 1-year After Subthalamic DBS in PD Patients: a Prospective Controlled Study. Parkinsonism Relat Disord. 2010;16(2):115-8. PubMed PMID: 19775926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychological changes 1-year after subthalamic DBS in PD patients: A prospective controlled study. AU - Castelli,Lorys, AU - Rizzi,Laura, AU - Zibetti,Maurizio, AU - Angrisano,Serena, AU - Lanotte,Michele, AU - Lopiano,Leonardo, Y1 - 2009/09/22/ PY - 2009/04/07/received PY - 2009/08/11/revised PY - 2009/08/13/accepted PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/5/5/medline SP - 115 EP - 8 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 16 IS - 2 N2 - OBJECTIVE: This study aimed at investigating the neuropsychological effect of DBS of the Subthalamic Nucleus in patients with advanced Parkinson's disease (PD). METHODS: A standardized neuropsychological test battery, assessing reasoning, memory and executive functions, was administered to 27 PD patients who underwent DBS-STN (DBS group) and to a matched control group of 31 PD patients under optimal medical treatment (MED group). Patients were evaluated at baseline and at the end of 1 year. RESULTS: Change score analysis (T1 minus T0 scores) demonstrated a significant decline in phonemic verbal fluency in the DBS group compared with the MED group (p < 0.005), while there were no significant changes between the two groups for the other cognitive tests. Single cases analysis by means of multivariate normative comparisons revealed that 4 out of 27 DBS patients (15%) showed cognitive deterioration one year post surgery. These patients were significantly more compromised from a motor standpoint (UPDRS, section III) than the 23 DBS PD patients who had no cognitive decline post surgery. CONCLUSION: Results of this prospective controlled-study showed that phonemic verbal fluency declined one year after DBS-STN, while the other cognitive domains did not change significantly. Nevertheless, single case analysis highlighted the fact that a subgroup comprising 15% of DBS-STN patients (4/27) showed significant cognitive decline 1 year after surgery. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/19775926/Neuropsychological_changes_1_year_after_subthalamic_DBS_in_PD_patients:_A_prospective_controlled_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(09)00220-X DB - PRIME DP - Unbound Medicine ER -