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Relationship between small airway function and health status, dyspnea and disease control in asthma.
Respiration. 2010; 80(2):120-6.R

Abstract

BACKGROUND

Small airways play important roles in the pathophysiology of asthma. However, relationships between small airway involvement and health status and dyspnea have not been investigated.

OBJECTIVES

It was the aim of this study to assess the relationships between proximal and peripheral airway functions and health status, dyspnea and disease control in patients with asthma, using impulse oscillometry (IOS).

METHODS

We performed IOS, spirometry and assessment of health status (Asthma Quality of Life Questionnaire and St. George's Respiratory Questionnaire), dyspnea (Baseline Dyspnea Index) and disease control (Asthma Control Questionnaire) in 65 asthmatics and evaluated their relationships.

RESULTS

Peripheral airway function as evaluated by IOS [R5-R20 (the fall in resistance from 5 to 20 Hz) and X5 (reactance at 5 Hz)], in addition to the proximal airway index (R20), significantly correlated with health status, dyspnea and disease control. Multiple regression analyses revealed that peripheral airway function significantly contributes to these, independently of the proximal airway index. In contrast, forced expiratory volume in 1 s did not significantly contribute to health status or dyspnea.

CONCLUSIONS

IOS correlated better with clinical symptoms and asthma control than spirometry in patients with asthma. Peripheral and proximal airway functions as assessed separately by IOS independently contribute to health status, dyspnea and disease control, indicating that peripheral airways also represent an important therapeutic target.

Authors+Show Affiliations

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19776554

Citation

Takeda, Tomoshi, et al. "Relationship Between Small Airway Function and Health Status, Dyspnea and Disease Control in Asthma." Respiration; International Review of Thoracic Diseases, vol. 80, no. 2, 2010, pp. 120-6.
Takeda T, Oga T, Niimi A, et al. Relationship between small airway function and health status, dyspnea and disease control in asthma. Respiration. 2010;80(2):120-6.
Takeda, T., Oga, T., Niimi, A., Matsumoto, H., Ito, I., Yamaguchi, M., Matsuoka, H., Jinnai, M., Otsuka, K., Oguma, T., Nakaji, H., Chin, K., & Mishima, M. (2010). Relationship between small airway function and health status, dyspnea and disease control in asthma. Respiration; International Review of Thoracic Diseases, 80(2), 120-6. https://doi.org/10.1159/000242113
Takeda T, et al. Relationship Between Small Airway Function and Health Status, Dyspnea and Disease Control in Asthma. Respiration. 2010;80(2):120-6. PubMed PMID: 19776554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between small airway function and health status, dyspnea and disease control in asthma. AU - Takeda,Tomoshi, AU - Oga,Toru, AU - Niimi,Akio, AU - Matsumoto,Hisako, AU - Ito,Isao, AU - Yamaguchi,Masafumi, AU - Matsuoka,Hirofumi, AU - Jinnai,Makiko, AU - Otsuka,Kojiro, AU - Oguma,Tsuyoshi, AU - Nakaji,Hitoshi, AU - Chin,Kazuo, AU - Mishima,Michiaki, Y1 - 2009/09/22/ PY - 2009/02/23/received PY - 2009/07/06/accepted PY - 2009/9/25/entrez PY - 2009/9/25/pubmed PY - 2010/11/9/medline SP - 120 EP - 6 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 80 IS - 2 N2 - BACKGROUND: Small airways play important roles in the pathophysiology of asthma. However, relationships between small airway involvement and health status and dyspnea have not been investigated. OBJECTIVES: It was the aim of this study to assess the relationships between proximal and peripheral airway functions and health status, dyspnea and disease control in patients with asthma, using impulse oscillometry (IOS). METHODS: We performed IOS, spirometry and assessment of health status (Asthma Quality of Life Questionnaire and St. George's Respiratory Questionnaire), dyspnea (Baseline Dyspnea Index) and disease control (Asthma Control Questionnaire) in 65 asthmatics and evaluated their relationships. RESULTS: Peripheral airway function as evaluated by IOS [R5-R20 (the fall in resistance from 5 to 20 Hz) and X5 (reactance at 5 Hz)], in addition to the proximal airway index (R20), significantly correlated with health status, dyspnea and disease control. Multiple regression analyses revealed that peripheral airway function significantly contributes to these, independently of the proximal airway index. In contrast, forced expiratory volume in 1 s did not significantly contribute to health status or dyspnea. CONCLUSIONS: IOS correlated better with clinical symptoms and asthma control than spirometry in patients with asthma. Peripheral and proximal airway functions as assessed separately by IOS independently contribute to health status, dyspnea and disease control, indicating that peripheral airways also represent an important therapeutic target. SN - 1423-0356 UR - https://www.unboundmedicine.com/medline/citation/19776554/Relationship_between_small_airway_function_and_health_status_dyspnea_and_disease_control_in_asthma_ L2 - https://www.karger.com?DOI=10.1159/000242113 DB - PRIME DP - Unbound Medicine ER -